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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063715
UUCD1 version UUC-MuM-00058
Ensembl Protein ID ENSMUSP00000140896.1
UniProt Accession Q9CQJ4; O35699; O35729; Q4FJV5; Q8C1X8; RING2_MOUSE
Genbank Protein ID CAA73380.1; CAA73321.1; BAE26638.1; BAB28186.1; BAB28663.1; BAC26898.1; BAC41075.1; CAJ18505.1; AAH20122.1
Protein Name E3 ubiquitin-protein ligase RING2; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2
Genbank Nucleotide ID Y12880; Y12783; AK145767; AK012358; AK013124; AK030319; AK090066; CT010297; BC020122
Gene Name Rnf2; DinG; Ring1b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026484.13 ENSMUST00000190070.6 ENSMUSP00000139676.1
ENSMUSG00000026484.13 ENSMUST00000187048.6 ENSMUSP00000140896.1
ENSMUSG00000026484.13 ENSMUST00000186415.6 ENSMUSP00000140594.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17157253; 17620408; 18650381; 20921134; 22910419
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.70e-07 31.7 51 91
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+adC+  ++       s++  CP+Cr
   Q: 51   CPICLDMLKNTMTTKECLHRFCADCIiTAL------RSGNKECPTCR 91
           **********555555*********98888......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Association to the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. Association to the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
Protein Sequence
(Fasta)
MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN 60
TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY 120
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Protein Fasta Sequence


>IUUC-Mmu-063715|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GCCTCCGCCT CCTCGCTCGC TCGCTCGCTC GCTCGCTCCT TCCCGCCCTC CCCGCAGCTC 60
CGGCCGAGCC GGCTCCCCCC TCCCCAGTCT CTCATGAATA TTGAGCGGCC CCTGTTGTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063715|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0071339--C:MLL1 complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0071535--F:RING-like zinc finger domain binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0009948--P:anterior/posterior axis specification
GO:0001702--P:gastrulation with mouth forming second
GO:0007281--P:germ cell development
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0000278--P:mitotic cell cycle
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG mmu:19821
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000516 Aegilops tauschii 57.81 6.00e-19 88.60
IUUC-Aml-001250 Ailuropoda melanoleuca 99.40 0.00e+00 694.00
IUUC-Apl-003587 Anas platyrhynchos 98.51 0.00e+00 695.00
IUUC-Aca-004928 Anolis carolinensis 97.92 0.00e+00 692.00
IUUC-Aly-005766 Arabidopsis lyrata 44.55 4.00e-23 102.00
IUUC-Ath-006899 Arabidopsis thaliana 50.00 6.00e-23 102.00
IUUC-Ame-010622 Astyanax mexicanus 89.29 0.00e+00 633.00
IUUC-Bta-013553 Bos taurus 99.70 0.00e+00 702.00
IUUC-Bdi-014202 Brachypodium distachyon 55.42 2.00e-24 107.00
IUUC-Bol-015993 Brassica oleracea 48.94 6.00e-24 105.00
IUUC-Bra-017150 Brassica rapa 48.04 6.00e-24 105.00
IUUC-Cja-019093 Callithrix jacchus 100.00 0.00e+00 704.00
IUUC-Cfa-020681 Canis familiaris 99.41 0.00e+00 699.00
IUUC-Cpo-021402 Cavia porcellus 84.52 3.00e-162 563.00
IUUC-Cre-022709 Chlamydomonas reinhardtii 35.48 4.00e-07 49.70
IUUC-Csa-024231 Chlorocebus sabaeus 99.70 0.00e+00 702.00
IUUC-Cho-024843 Choloepus hoffmanni 84.52 2.00e-163 568.00
IUUC-Csv-026314 Ciona savignyi 47.03 1.00e-82 300.00
IUUC-Dre-027685 Danio rerio 89.29 0.00e+00 633.00
IUUC-Dno-029993 Dasypus novemcinctus 98.81 0.00e+00 698.00
IUUC-Dor-030986 Dipodomys ordii 71.73 6.00e-133 466.00
IUUC-Dme-031721 Drosophila melanogaster 78.91 7.00e-68 251.00
IUUC-Ete-032564 Echinops telfairi 82.44 6.00e-161 560.00
IUUC-Eca-033251 Equus caballus 99.70 0.00e+00 702.00
IUUC-Eeu-034951 Erinaceus europaeus 99.70 0.00e+00 702.00
IUUC-Fca-036240 Felis catus 99.40 0.00e+00 696.00
IUUC-Fal-037376 Ficedula albicollis 98.21 0.00e+00 692.00
IUUC-Gmo-038879 Gadus morhua 85.55 6.00e-166 576.00
IUUC-Gga-041134 Gallus gallus 98.21 0.00e+00 693.00
IUUC-Gac-042589 Gasterosteus aculeatus 85.88 1.00e-167 582.00
IUUC-Gma-044386 Glycine max 33.77 2.00e-23 103.00
IUUC-Ggo-044529 Gorilla gorilla 99.70 0.00e+00 702.00
IUUC-Hsa-046100 Homo sapiens 99.70 0.00e+00 702.00
IUUC-Hvu-047152 Hordeum vulgare 54.22 5.00e-24 105.00
IUUC-Itr-047891 Ictidomys tridecemlineatus 99.40 0.00e+00 701.00
IUUC-Lch-049494 Latimeria chalumnae 89.88 6.00e-178 616.00
IUUC-Lpe-050923 Leersia perrieri 44.35 6.00e-25 108.00
IUUC-Loc-052544 Lepisosteus oculatus 88.30 0.00e+00 630.00
IUUC-Laf-053675 Loxodonta africana 99.35 0.00e+00 637.00
IUUC-Mcc-055685 Macaca mulatta 99.70 0.00e+00 701.00
IUUC-Mtr-058234 Medicago truncatula 50.60 1.00e-23 104.00
IUUC-Mga-059354 Meleagris gallopavo 98.51 0.00e+00 695.00
IUUC-Mmr-060809 Microcebus murinus 100.00 0.00e+00 704.00
IUUC-Mdo-062206 Monodelphis domestica 99.11 0.00e+00 699.00
IUUC-Mpu-066460 Mustela putorius furo 99.70 0.00e+00 702.00
IUUC-Mlu-067743 Myotis lucifugus 99.70 0.00e+00 702.00
IUUC-Nle-069512 Nomascus leucogenys 99.70 0.00e+00 702.00
IUUC-Opr-070807 Ochotona princeps 99.45 5.00e-106 377.00
IUUC-Ont-072541 Oreochromis niloticus 86.26 1.00e-169 588.00
IUUC-Oan-073454 Ornithorhynchus anatinus 99.11 0.00e+00 699.00
IUUC-Ocu-073981 Oryctolagus cuniculus 99.40 0.00e+00 701.00
IUUC-Oba-075605 Oryza barthii 53.01 1.00e-23 105.00
IUUC-Obr-076282 Oryza brachyantha 44.35 4.00e-25 109.00
IUUC-Ogl-077288 Oryza glaberrima 43.48 9.00e-25 108.00
IUUC-Ogu-078992 Oryza glumaepatula 53.01 1.00e-23 104.00
IUUC-Oin-079939 Oryza indica 43.48 8.00e-25 108.00
IUUC-Olo-080262 Oryza longistaminata 45.22 3.00e-25 110.00
IUUC-Ome-081418 Oryza meridionalis 44.35 5.00e-25 108.00
IUUC-Oni-083103 Oryza nivara 43.48 9.00e-25 108.00
IUUC-Opu-083314 Oryza punctata 44.35 7.00e-25 108.00
IUUC-Oru-084356 Oryza rufipogon 51.81 2.00e-23 104.00
IUUC-Osa-085727 Oryza sativa 43.48 8.00e-25 108.00
IUUC-Ola-086937 Oryzias latipes 87.24 2.00e-169 588.00
IUUC-Oga-089078 Otolemur garnettii 84.96 2.00e-119 421.00
IUUC-Oar-089823 Ovis aries 99.70 0.00e+00 702.00
IUUC-Ptr-090557 Pan troglodytes 99.70 0.00e+00 702.00
IUUC-Pan-091950 Papio anubis 99.70 0.00e+00 702.00
IUUC-Psi-093349 Pelodiscus sinensis 98.21 0.00e+00 693.00
IUUC-Ppa-095164 Physcomitrella patens 58.21 6.00e-22 98.60
IUUC-Pfo-096803 Poecilia formosa 85.96 2.00e-168 584.00
IUUC-Pab-098392 Pongo abelii 98.81 0.00e+00 697.00
IUUC-Pop-100011 Populus trichocarpa 50.52 4.00e-25 109.00
IUUC-Pca-100946 Procavia capensis 99.21 1.00e-150 525.00
IUUC-Ppe-101894 Prunus persica 61.82 2.00e-17 83.20
IUUC-Pva-102498 Pteropus vampyrus 99.25 9.00e-78 283.00
IUUC-Rno-105492 Rattus norvegicus 100.00 0.00e+00 704.00
IUUC-Sha-107645 Sarcophilus harrisii 98.81 0.00e+00 698.00
IUUC-Smo-108741 Selaginella moellendorffii 51.95 4.00e-22 95.50
IUUC-Sit-109707 Setaria italica 44.35 2.00e-25 110.00
IUUC-Sly-111537 Solanum lycopersicum 54.41 4.00e-19 89.40
IUUC-Sar-113064 Sorex araneus 97.62 4.00e-72 264.00
IUUC-Sbi-114798 Sorghum bicolor 43.48 2.00e-24 107.00
IUUC-Ssc-115830 Sus scrofa 99.70 0.00e+00 701.00
IUUC-Tgu-116694 Taeniopygia guttata 98.81 0.00e+00 697.00
IUUC-Tru-117837 Takifugu rubripes 85.67 2.00e-167 581.00
IUUC-Tsy-119174 Tarsius syrichta 98.21 0.00e+00 687.00
IUUC-Tni-120389 Tetraodon nigroviridis 85.71 1.00e-166 578.00
IUUC-Tca-121428 Theobroma cacao 32.69 1.00e-24 107.00
IUUC-Tae-125498 Triticum aestivum 54.22 4.00e-24 106.00
IUUC-Tur-126796 Triticum urartu 54.22 5.00e-24 105.00
IUUC-Tbe-127428 Tupaia belangeri 99.45 4.00e-106 376.00
IUUC-Ttr-128796 Tursiops truncatus 99.40 0.00e+00 701.00
IUUC-Vpa-130691 Vicugna pacos 99.70 0.00e+00 702.00
IUUC-Vvi-131143 Vitis vinifera 42.42 3.00e-25 109.00
IUUC-Xtr-132022 Xenopus tropicalis 93.75 0.00e+00 665.00
IUUC-Xma-133424 Xiphophorus maculatus 85.67 2.00e-168 584.00
Created Date 25-Jun-2017

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