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Tag Content
UUCD2 ID IUUC-Cfa-021041
UUCD1 version UUC-CaF-00838
Ensembl Protein ID ENSCAFP00000041311.1
UniProt Accession J9P6M8; J9P6M8_CANLF
Genbank Protein ID ENSCAFP00000041311
Protein Name E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Genbank Nucleotide ID AAEX03008298
Gene Name RNF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000030176.2 ENSCAFT00000047572.2 ENSCAFP00000041311.1
ENSCAFG00000030176.2 ENSCAFT00000002283.3 ENSCAFP00000002119.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 3.90e-07 30.8 405 443
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 405  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 443
           ********99.899***************......**********8 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MEEPGSLVTG DRAGGRRWCL RRARMNAEWL LLEDGNEVTI GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNV EGQWTIMDNK SLNGVWLNRE RLEPLKVYSI HKGDHIQLGV PLENKENAEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-021041|E3,RING|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCGGTTGG CGGCCGAGGG GGCGGGGCGC GCAGCCCGAG CGAGAGTTCA CATCGATCGC 60
GAGCGCGTAG CGATTGCTTC TGTCTGTTGT TTAGTTATGG CGCCGGCGAC GAGGCTGAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-021041|E3,RING|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
PF00097--zf-C3HC4
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cfa:481775
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002124 Ailuropoda melanoleuca 90.48 0.00e+00 707.00
IUUC-Apl-003664 Anas platyrhynchos 78.89 6.00e-39 152.00
IUUC-Aca-005036 Anolis carolinensis 57.41 6.00e-122 431.00
IUUC-Ame-011537 Astyanax mexicanus 41.46 6.00e-85 308.00
IUUC-Bta-013297 Bos taurus 86.63 0.00e+00 650.00
IUUC-Cja-019201 Callithrix jacchus 83.13 0.00e+00 650.00
IUUC-Csa-024133 Chlorocebus sabaeus 84.98 0.00e+00 701.00
IUUC-Cho-024624 Choloepus hoffmanni 81.34 2.00e-144 504.00
IUUC-Dre-027918 Danio rerio 42.59 2.00e-82 300.00
IUUC-Dno-029774 Dasypus novemcinctus 87.06 0.00e+00 723.00
IUUC-Dor-030190 Dipodomys ordii 75.56 8.00e-154 536.00
IUUC-Ete-032301 Echinops telfairi 68.39 4.00e-142 497.00
IUUC-Eca-033607 Equus caballus 90.02 0.00e+00 631.00
IUUC-Eeu-034888 Erinaceus europaeus 84.04 5.00e-128 451.00
IUUC-Fca-036075 Felis catus 89.53 0.00e+00 758.00
IUUC-Fal-037569 Ficedula albicollis 62.47 2.00e-118 419.00
IUUC-Gmo-038588 Gadus morhua 39.28 2.00e-70 259.00
IUUC-Gga-040777 Gallus gallus 60.81 8.00e-122 430.00
IUUC-Gac-042463 Gasterosteus aculeatus 41.63 3.00e-61 229.00
IUUC-Ggo-045269 Gorilla gorilla 85.60 0.00e+00 712.00
IUUC-Hsa-046249 Homo sapiens 85.60 0.00e+00 691.00
IUUC-Itr-048314 Ictidomys tridecemlineatus 86.80 0.00e+00 711.00
IUUC-Kpa-049392 Komagataella pastoris 36.05 2.00e-08 52.80
IUUC-Lch-049805 Latimeria chalumnae 50.85 4.00e-113 401.00
IUUC-Loc-052377 Lepisosteus oculatus 49.90 2.00e-95 342.00
IUUC-Mcc-055344 Macaca mulatta 84.77 0.00e+00 702.00
IUUC-Meu-055950 Macropus eugenii 63.60 2.00e-126 445.00
IUUC-Mla-059052 Melampsora laricipopulina 38.16 9.00e-11 60.10
IUUC-Mga-060049 Meleagris gallopavo 60.08 7.00e-121 427.00
IUUC-Mmr-061431 Microcebus murinus 86.96 0.00e+00 687.00
IUUC-Mdo-062016 Monodelphis domestica 69.91 4.00e-126 446.00
IUUC-Mmu-063235 Mus musculus 75.61 0.00e+00 646.00
IUUC-Mpu-066449 Mustela putorius furo 94.21 0.00e+00 800.00
IUUC-Mlu-067588 Myotis lucifugus 82.82 0.00e+00 656.00
IUUC-Nle-069192 Nomascus leucogenys 85.60 0.00e+00 709.00
IUUC-Opr-070300 Ochotona princeps 67.49 4.00e-151 528.00
IUUC-Ont-071998 Oreochromis niloticus 42.68 4.00e-65 242.00
IUUC-Oan-073610 Ornithorhynchus anatinus 65.65 2.00e-67 248.00
IUUC-Ocu-074603 Oryctolagus cuniculus 81.52 0.00e+00 655.00
IUUC-Ola-086681 Oryzias latipes 40.80 3.00e-72 266.00
IUUC-Oga-088183 Otolemur garnettii 87.24 0.00e+00 712.00
IUUC-Oar-090255 Ovis aries 87.28 4.00e-172 597.00
IUUC-Ptr-091029 Pan troglodytes 84.72 0.00e+00 647.00
IUUC-Pan-092241 Papio anubis 84.98 0.00e+00 707.00
IUUC-Psi-093506 Pelodiscus sinensis 63.24 2.00e-135 475.00
IUUC-Pma-094579 Petromyzon marinus 56.67 1.00e-26 114.00
IUUC-Pfo-097014 Poecilia formosa 42.58 2.00e-62 233.00
IUUC-Pab-098530 Pongo abelii 85.28 0.00e+00 661.00
IUUC-Pca-100939 Procavia capensis 66.67 1.00e-150 526.00
IUUC-Pva-103148 Pteropus vampyrus 81.93 0.00e+00 661.00
IUUC-Rno-105338 Rattus norvegicus 77.16 0.00e+00 668.00
IUUC-Sce-106282 Saccharomyces cerevisiae 35.96 2.00e-06 47.00
IUUC-Sha-107187 Sarcophilus harrisii 68.15 4.00e-108 384.00
IUUC-Sar-113356 Sorex araneus 69.53 8.00e-135 473.00
IUUC-Ssc-116290 Sus scrofa 88.41 0.00e+00 772.00
IUUC-Tru-117910 Takifugu rubripes 40.43 1.00e-61 230.00
IUUC-Tsy-119329 Tarsius syrichta 80.89 4.00e-168 583.00
IUUC-Tni-120521 Tetraodon nigroviridis 39.83 5.00e-63 234.00
IUUC-Tme-126989 Tuber melanosporum 32.76 8.00e-07 48.90
IUUC-Ttr-128997 Tursiops truncatus 83.11 0.00e+00 658.00
IUUC-Vpa-130154 Vicugna pacos 85.83 0.00e+00 725.00
IUUC-Xtr-132805 Xenopus tropicalis 50.21 1.00e-107 383.00
IUUC-Xma-133620 Xiphophorus maculatus 42.61 6.00e-61 228.00
Created Date 25-Jun-2017

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