iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036075

Ensembl Protein ID

ENSFCAP00000018646.1

UniProt Accession

M3WWA8; M3WWA8_FELCA

Genbank Protein ID

ENSFCAP00000018646

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AANG02088221

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000021983.1	ENSFCAT00000021958.1	ENSFCAP00000018646.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.80e-07	29.8	391	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C+  w       +++  CP+Cr
   Q: 391  CIICSEYFIE-AVTLNCAHSFCSYCISEW------MKRKVECPICR 429
           ********99.899***************......**********8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MGEPGSLVTG DRAGGRSWCL RRVGMDAEWL LLEDGNEVTI GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNV EGQWTIMDNK SLNGVWLNRQ RLEPLNVYSI HKGDHIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAGC CCGGCTCGTT GGTCACGGGA GACCGCGCCG GTGGCCGGAG TTGGTGCTTG 60
CGACGGGTGG GGATGGACGC TGAGTGGCTG CTGCTCGAGG ACGGAAACGA GGTGAGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF00097--zf-C3HC4

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	88.61	0.00e+00	701.00
IUUC-Apl-003664	Anas platyrhynchos	77.78	2.00e-38	150.00
IUUC-Aca-005036	Anolis carolinensis	56.47	3.00e-111	395.00
IUUC-Acl-008377	Aspergillus clavatus	32.43	5.00e-08	52.40
IUUC-Ame-011537	Astyanax mexicanus	42.62	1.00e-86	313.00
IUUC-Bta-013297	Bos taurus	84.77	0.00e+00	669.00
IUUC-Cja-019201	Callithrix jacchus	80.83	0.00e+00	636.00
IUUC-Cfa-021041	Canis familiaris	89.71	0.00e+00	743.00
IUUC-Csa-024133	Chlorocebus sabaeus	83.54	0.00e+00	693.00
IUUC-Cho-024624	Choloepus hoffmanni	77.36	3.00e-133	468.00
IUUC-Dre-027918	Danio rerio	43.72	3.00e-82	298.00
IUUC-Dno-029774	Dasypus novemcinctus	84.36	0.00e+00	696.00
IUUC-Dor-030190	Dipodomys ordii	70.94	1.00e-148	519.00
IUUC-Ete-032301	Echinops telfairi	66.32	3.00e-137	481.00
IUUC-Eca-033607	Equus caballus	86.89	2.00e-176	612.00
IUUC-Eeu-034888	Erinaceus europaeus	80.59	8.00e-121	427.00
IUUC-Fal-037569	Ficedula albicollis	62.47	7.00e-111	394.00
IUUC-Gmo-038588	Gadus morhua	40.38	2.00e-68	252.00
IUUC-Gga-040777	Gallus gallus	58.70	5.00e-119	421.00
IUUC-Gac-042463	Gasterosteus aculeatus	42.64	2.00e-60	226.00
IUUC-Ggo-045269	Gorilla gorilla	84.16	0.00e+00	705.00
IUUC-Hsa-046249	Homo sapiens	83.74	0.00e+00	684.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	84.85	0.00e+00	699.00
IUUC-Lch-049805	Latimeria chalumnae	50.21	6.00e-116	411.00
IUUC-Loc-052377	Lepisosteus oculatus	50.84	3.00e-94	338.00
IUUC-Mcc-055344	Macaca mulatta	83.33	0.00e+00	696.00
IUUC-Meu-055950	Macropus eugenii	61.28	9.00e-122	430.00
IUUC-Mla-059052	Melampsora laricipopulina	36.92	6.00e-10	57.40
IUUC-Mga-060049	Meleagris gallopavo	60.00	3.00e-116	411.00
IUUC-Mmr-061431	Microcebus murinus	85.51	0.00e+00	665.00
IUUC-Mdo-062016	Monodelphis domestica	65.16	3.00e-121	430.00
IUUC-Mmu-063235	Mus musculus	71.93	1.00e-178	619.00
IUUC-Mpu-066449	Mustela putorius furo	92.36	0.00e+00	793.00
IUUC-Mlu-067588	Myotis lucifugus	80.95	0.00e+00	640.00
IUUC-Nle-069192	Nomascus leucogenys	84.16	0.00e+00	702.00
IUUC-Opr-070300	Ochotona princeps	63.17	1.00e-141	496.00
IUUC-Ont-071998	Oreochromis niloticus	42.95	7.00e-63	234.00
IUUC-Oan-073610	Ornithorhynchus anatinus	70.59	8.00e-65	239.00
IUUC-Ocu-074603	Oryctolagus cuniculus	78.44	0.00e+00	632.00
IUUC-Ola-086681	Oryzias latipes	40.90	1.00e-70	260.00
IUUC-Oga-088183	Otolemur garnettii	85.74	0.00e+00	710.00
IUUC-Oar-090255	Ovis aries	84.56	6.00e-174	603.00
IUUC-Ptr-091029	Pan troglodytes	82.31	0.00e+00	630.00
IUUC-Pan-092241	Papio anubis	83.54	0.00e+00	700.00
IUUC-Psi-093506	Pelodiscus sinensis	62.19	1.00e-132	466.00
IUUC-Pma-094579	Petromyzon marinus	51.46	6.00e-27	115.00
IUUC-Pfo-097014	Poecilia formosa	41.45	6.00e-62	231.00
IUUC-Pab-098530	Pongo abelii	83.12	0.00e+00	646.00
IUUC-Pca-100939	Procavia capensis	63.17	1.00e-147	516.00
IUUC-Pva-103148	Pteropus vampyrus	79.84	0.00e+00	656.00
IUUC-Rno-105338	Rattus norvegicus	74.28	0.00e+00	652.00
IUUC-Sce-106282	Saccharomyces cerevisiae	35.96	7.00e-07	48.10
IUUC-Sha-107187	Sarcophilus harrisii	64.69	8.00e-103	367.00
IUUC-Sar-113356	Sorex araneus	66.25	6.00e-122	430.00
IUUC-Ssc-116290	Sus scrofa	85.89	0.00e+00	737.00
IUUC-Tru-117910	Takifugu rubripes	41.04	5.00e-62	231.00
IUUC-Tsy-119329	Tarsius syrichta	77.33	4.00e-161	560.00
IUUC-Tni-120521	Tetraodon nigroviridis	40.52	7.00e-61	228.00
IUUC-Ttr-128997	Tursiops truncatus	79.33	0.00e+00	635.00
IUUC-Vpa-130154	Vicugna pacos	83.61	0.00e+00	710.00
IUUC-Xtr-132805	Xenopus tropicalis	49.69	5.00e-102	364.00
IUUC-Xma-133620	Xiphophorus maculatus	42.89	1.00e-61	230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence