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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105889
Ensembl Protein ID ENSRNOP00000069644.1
UniProt Accession A0A0G2JVW5; A0A0G2JVW5_RAT
Genbank Protein ID ENSRNOP00000069644
Protein Name E3 ubiquitin-protein ligase HUWE1
Genbank Nucleotide ID AABR07037465
Gene Name Huwe1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000061262.1 ENSRNOT00000081037.1 ENSRNOP00000069644.1
ENSRNOG00000061262.1 ENSRNOT00000090890.1 ENSRNOP00000071818.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBA 6.40e-08 32.9 1318 1355
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1318 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1355
           89**********************.7***********98 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105889|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAAGTAG ACAGGACTAA ACTCAAAAAG ACACCTACTG AGGCTGTGAG TATCCAAATT 60
TGCTTTGTGC GTTTTCTTTA TTCCAGGAAA AAAAAATCAT TGTGACCAGT TCAGCAGTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105889|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE
Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00627--UBA
PF02825--WWE
SMART

SM00165--UBA
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001684 Ailuropoda melanoleuca 90.46 0.00e+00 3957.00
IUUC-Aca-005263 Anolis carolinensis 82.79 0.00e+00 2741.00
IUUC-Ame-011067 Astyanax mexicanus 74.50 0.00e+00 3308.00
IUUC-Bta-012813 Bos taurus 90.42 0.00e+00 3984.00
IUUC-Bol-015228 Brassica oleracea 22.70 2.00e-30 129.00
IUUC-Cja-018741 Callithrix jacchus 90.84 0.00e+00 3971.00
IUUC-Cfa-020083 Canis familiaris 88.85 0.00e+00 3947.00
IUUC-Cpo-021923 Cavia porcellus 90.71 0.00e+00 3966.00
IUUC-Csa-023853 Chlorocebus sabaeus 91.00 0.00e+00 3981.00
IUUC-Cho-024718 Choloepus hoffmanni 75.06 1.00e-172 602.00
IUUC-Cin-025627 Ciona intestinalis 50.63 0.00e+00 1352.00
IUUC-Csv-025824 Ciona savignyi 50.21 0.00e+00 1260.00
IUUC-Dre-028525 Danio rerio 75.27 0.00e+00 3278.00
IUUC-Dno-029680 Dasypus novemcinctus 89.55 0.00e+00 3893.00
IUUC-Dor-030902 Dipodomys ordii 95.61 0.00e+00 1185.00
IUUC-Dme-032122 Drosophila melanogaster 44.60 8.00e-107 384.00
IUUC-Ete-032690 Echinops telfairi 74.14 0.00e+00 920.00
IUUC-Eca-033915 Equus caballus 90.45 0.00e+00 3944.00
IUUC-Eeu-034963 Erinaceus europaeus 94.28 0.00e+00 2612.00
IUUC-Fca-035824 Felis catus 90.46 0.00e+00 3965.00
IUUC-Gmo-039073 Gadus morhua 76.64 0.00e+00 3310.00
IUUC-Gac-042430 Gasterosteus aculeatus 77.15 0.00e+00 3385.00
IUUC-Ggo-044785 Gorilla gorilla 91.00 0.00e+00 3938.00
IUUC-Hsa-046879 Homo sapiens 91.04 0.00e+00 3940.00
IUUC-Itr-048430 Ictidomys tridecemlineatus 91.69 0.00e+00 901.00
IUUC-Lch-050252 Latimeria chalumnae 81.22 0.00e+00 3037.00
IUUC-Loc-052472 Lepisosteus oculatus 77.30 0.00e+00 3386.00
IUUC-Laf-054154 Loxodonta africana 89.77 0.00e+00 3948.00
IUUC-Mcc-055085 Macaca mulatta 89.42 0.00e+00 3926.00
IUUC-Meu-056727 Macropus eugenii 94.53 0.00e+00 1886.00
IUUC-Mmr-060820 Microcebus murinus 88.89 0.00e+00 3898.00
IUUC-Mdo-062930 Monodelphis domestica 84.95 0.00e+00 3743.00
IUUC-Mmu-063601 Mus musculus 92.16 0.00e+00 3919.00
IUUC-Mpu-066653 Mustela putorius furo 88.53 0.00e+00 3837.00
IUUC-Mlu-067418 Myotis lucifugus 90.10 0.00e+00 4008.00
IUUC-Nle-069418 Nomascus leucogenys 90.63 0.00e+00 3905.00
IUUC-Opr-070187 Ochotona princeps 89.55 3.00e-168 587.00
IUUC-Ont-071300 Oreochromis niloticus 77.39 0.00e+00 3345.00
IUUC-Oan-073046 Ornithorhynchus anatinus 81.96 0.00e+00 4628.00
IUUC-Ocu-074178 Oryctolagus cuniculus 90.46 0.00e+00 4003.00
IUUC-Osa-086016 Oryza sativa 25.05 1.00e-19 92.40
IUUC-Ola-087437 Oryzias latipes 76.23 0.00e+00 1865.00
IUUC-Oga-088903 Otolemur garnettii 90.13 0.00e+00 3921.00
IUUC-Oar-090210 Ovis aries 89.04 0.00e+00 3934.00
IUUC-Ptr-090502 Pan troglodytes 88.94 0.00e+00 2934.00
IUUC-Pan-092368 Papio anubis 88.82 0.00e+00 2972.00
IUUC-Pma-094246 Petromyzon marinus 63.29 0.00e+00 1057.00
IUUC-Pfo-096232 Poecilia formosa 75.11 0.00e+00 3342.00
IUUC-Pab-098583 Pongo abelii 91.09 0.00e+00 3944.00
IUUC-Pca-100310 Procavia capensis 83.35 0.00e+00 1623.00
IUUC-Pva-102116 Pteropus vampyrus 90.42 0.00e+00 3988.00
IUUC-Sha-106961 Sarcophilus harrisii 83.33 0.00e+00 3691.00
IUUC-Sar-113291 Sorex araneus 80.88 0.00e+00 2276.00
IUUC-Sre-115094 Sporisorium reilianum 26.29 8.00e-48 187.00
IUUC-Ssc-115754 Sus scrofa 90.59 0.00e+00 3967.00
IUUC-Tru-118570 Takifugu rubripes 76.77 0.00e+00 3413.00
IUUC-Tsy-119159 Tarsius syrichta 97.47 0.00e+00 1908.00
IUUC-Tni-120836 Tetraodon nigroviridis 68.20 0.00e+00 1667.00
IUUC-Tbe-127506 Tupaia belangeri 87.93 0.00e+00 1116.00
IUUC-Ttr-129253 Tursiops truncatus 76.68 0.00e+00 1739.00
IUUC-Uma-129331 Ustilago maydis 26.48 2.00e-43 172.00
IUUC-Vpa-130708 Vicugna pacos 87.68 0.00e+00 3411.00
IUUC-Vvi-131559 Vitis vinifera 25.59 7.00e-41 163.00
IUUC-Xtr-132123 Xenopus tropicalis 79.94 0.00e+00 4529.00
Created Date 25-Jun-2017

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