iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093245

Ensembl Protein ID

ENSPSIP00000014467.1

UniProt Accession

K7G2F6; K7G2F6_PELSI

Genbank Protein ID

ENSPSIP00000014467

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGCU01076990

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000012894.1	ENSPSIT00000014535.1	ENSPSIP00000014467.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.30e-15	56.0	1223	1267

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 1    ekvClvCgeggedekslveCek.CrewfHpaClklsveeelpnsekwiCpkCr 52
           e+vC +C+++ge    l+ Ce  C+ +fH +Cl+ls   e+p+ + +iC++C+
   Q: 1223 ENVCQICEKPGE----LLLCEAqCCGAFHLQCLGLS---EMPKGK-FICTECS 1267
           589*********....*****99*************...9****7.******6 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

KKKPAPVKYE VGDLVWAKFN RRPWWPCTIC HDPVLDCHSK MKVSNRRPYR EYYVDALGDP 60
SERAWVAGKA IVLFEGRYQF EELPILRRRG KQKEKGYKHK VPQRFMAKWE LSVGHAEEFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCGAGCCA AGAAGAAACC TGCTCCAGTG AAGTATGAAG TTGGAGATCT AGTCTGGGCT 60
AAGTTCAACA GACGACCATG GTGGCCCTGC ACAATCTGTC ACGATCCAGT GCTCGACTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001795	Ailuropoda melanoleuca	59.19	0.00e+00	2053.00
IUUC-Apl-003953	Anas platyrhynchos	70.73	0.00e+00	2521.00
IUUC-Aca-005339	Anolis carolinensis	57.09	0.00e+00	1801.00
IUUC-Bta-012966	Bos taurus	59.26	0.00e+00	2098.00
IUUC-Bdi-014781	Brachypodium distachyon	29.13	5.00e-14	72.80
IUUC-Bra-017864	Brassica rapa	32.08	4.00e-14	74.30
IUUC-Cja-018780	Callithrix jacchus	59.83	0.00e+00	2102.00
IUUC-Cfa-020975	Canis familiaris	59.49	0.00e+00	2092.00
IUUC-Cpo-021331	Cavia porcellus	70.90	0.00e+00	1559.00
IUUC-Csa-024226	Chlorocebus sabaeus	59.33	0.00e+00	2062.00
IUUC-Cho-024464	Choloepus hoffmanni	44.73	0.00e+00	684.00
IUUC-Dre-027488	Danio rerio	62.10	0.00e+00	1225.00
IUUC-Dno-029230	Dasypus novemcinctus	57.68	0.00e+00	1998.00
IUUC-Dor-031016	Dipodomys ordii	77.37	0.00e+00	1032.00
IUUC-Eca-033591	Equus caballus	59.47	0.00e+00	2101.00
IUUC-Fca-035791	Felis catus	59.70	0.00e+00	2109.00
IUUC-Fal-037378	Ficedula albicollis	69.15	0.00e+00	2323.00
IUUC-Gmo-038919	Gadus morhua	70.32	0.00e+00	914.00
IUUC-Gga-040881	Gallus gallus	69.13	0.00e+00	2458.00
IUUC-Gac-041378	Gasterosteus aculeatus	77.22	0.00e+00	1040.00
IUUC-Hsa-046436	Homo sapiens	60.04	0.00e+00	2093.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	59.25	0.00e+00	2098.00
IUUC-Lch-049684	Latimeria chalumnae	61.40	0.00e+00	1283.00
IUUC-Laf-054046	Loxodonta africana	59.04	0.00e+00	2026.00
IUUC-Mcc-055593	Macaca mulatta	59.38	0.00e+00	2071.00
IUUC-Mga-059756	Meleagris gallopavo	69.62	0.00e+00	2469.00
IUUC-Mmr-061182	Microcebus murinus	59.87	0.00e+00	2128.00
IUUC-Mdo-061984	Monodelphis domestica	60.12	0.00e+00	1989.00
IUUC-Mmu-063605	Mus musculus	58.34	0.00e+00	2082.00
IUUC-Mpu-066446	Mustela putorius furo	59.37	0.00e+00	2098.00
IUUC-Mlu-067261	Myotis lucifugus	59.82	0.00e+00	2097.00
IUUC-Nle-069818	Nomascus leucogenys	60.22	0.00e+00	2094.00
IUUC-Opr-070842	Ochotona princeps	69.97	0.00e+00	1368.00
IUUC-Ont-072448	Oreochromis niloticus	73.43	0.00e+00	1116.00
IUUC-Oan-073496	Ornithorhynchus anatinus	77.90	0.00e+00	1543.00
IUUC-Ocu-074918	Oryctolagus cuniculus	59.23	0.00e+00	2109.00
IUUC-Ola-087518	Oryzias latipes	74.11	0.00e+00	1021.00
IUUC-Oga-088743	Otolemur garnettii	59.83	0.00e+00	2046.00
IUUC-Oar-090265	Ovis aries	59.26	0.00e+00	2100.00
IUUC-Ptr-090521	Pan troglodytes	60.04	0.00e+00	2099.00
IUUC-Pfo-096066	Poecilia formosa	61.14	0.00e+00	1196.00
IUUC-Pab-098644	Pongo abelii	59.84	0.00e+00	2071.00
IUUC-Pva-103094	Pteropus vampyrus	89.73	0.00e+00	1111.00
IUUC-Rno-105803	Rattus norvegicus	58.64	0.00e+00	2066.00
IUUC-Sha-107278	Sarcophilus harrisii	59.91	0.00e+00	2062.00
IUUC-Sar-113402	Sorex araneus	85.50	0.00e+00	1030.00
IUUC-Ssc-116193	Sus scrofa	59.65	0.00e+00	2063.00
IUUC-Tgu-116532	Taeniopygia guttata	93.18	0.00e+00	1266.00
IUUC-Tru-117988	Takifugu rubripes	76.82	0.00e+00	1165.00
IUUC-Tsy-118830	Tarsius syrichta	59.00	0.00e+00	2026.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence