iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107521

Ensembl Protein ID

ENSSHAP00000008743.1

UniProt Accession

G3VZY8; G3VZY8_SARHA

Genbank Protein ID

ENSSHAP00000008743

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01128092

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000007571.1	ENSSHAT00000008815.1	ENSSHAP00000008743.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-44	150.4	196	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++ vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ l
   Q: 196  VLHIVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGQIGLVPKNYVVIL 255
           5789**************************************.7**************866 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANKTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSTRDAS PTPSTDAEYP SNGSTADRIY DLNIPAYVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTACTAAC ATATATGCAT GCTTAATAGT AAACCTTTGT TGATTGATTA ATAATTTAAG 60
TATCTTTATT TTAAGCTTTT GTATTTAAAT ATCATTATTT TAAGTCTTTC CATCTTAGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

shr:100931923

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	92.11	0.00e+00	724.00
IUUC-Apl-003456	Anas platyrhynchos	96.58	0.00e+00	749.00
IUUC-Aca-005105	Anolis carolinensis	96.32	0.00e+00	746.00
IUUC-Ame-010966	Astyanax mexicanus	78.39	4.00e-176	610.00
IUUC-Bta-012424	Bos taurus	84.21	0.00e+00	633.00
IUUC-Cja-019898	Callithrix jacchus	92.11	0.00e+00	725.00
IUUC-Cfa-020830	Canis familiaris	91.05	0.00e+00	719.00
IUUC-Cpo-021487	Cavia porcellus	82.89	0.00e+00	633.00
IUUC-Csa-023693	Chlorocebus sabaeus	92.37	0.00e+00	728.00
IUUC-Cin-025348	Ciona intestinalis	38.55	6.00e-69	254.00
IUUC-Dre-028334	Danio rerio	82.25	0.00e+00	627.00
IUUC-Dno-028973	Dasypus novemcinctus	93.16	0.00e+00	727.00
IUUC-Dor-031003	Dipodomys ordii	90.00	0.00e+00	682.00
IUUC-Ete-032792	Echinops telfairi	84.38	0.00e+00	655.00
IUUC-Eca-033656	Equus caballus	92.11	0.00e+00	724.00
IUUC-Fca-036347	Felis catus	92.11	0.00e+00	723.00
IUUC-Fal-037095	Ficedula albicollis	97.11	0.00e+00	751.00
IUUC-Gmo-039410	Gadus morhua	69.39	6.00e-161	560.00
IUUC-Gga-040155	Gallus gallus	96.58	0.00e+00	749.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.34	1.00e-165	575.00
IUUC-Ggo-044805	Gorilla gorilla	92.37	0.00e+00	726.00
IUUC-Hsa-046585	Homo sapiens	92.37	0.00e+00	726.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	90.79	0.00e+00	698.00
IUUC-Lch-049795	Latimeria chalumnae	91.05	0.00e+00	711.00
IUUC-Loc-051985	Lepisosteus oculatus	90.26	0.00e+00	677.00
IUUC-Laf-054228	Loxodonta africana	94.47	0.00e+00	733.00
IUUC-Mcc-055402	Macaca mulatta	92.37	0.00e+00	728.00
IUUC-Mga-059374	Meleagris gallopavo	96.58	0.00e+00	749.00
IUUC-Mmr-061453	Microcebus murinus	92.11	0.00e+00	723.00
IUUC-Mdo-063080	Monodelphis domestica	99.47	0.00e+00	764.00
IUUC-Mmu-063529	Mus musculus	89.21	0.00e+00	695.00
IUUC-Mpu-066815	Mustela putorius furo	92.11	0.00e+00	724.00
IUUC-Mlu-067132	Myotis lucifugus	87.87	1.00e-157	548.00
IUUC-Nle-069371	Nomascus leucogenys	92.37	0.00e+00	726.00
IUUC-Opr-070948	Ochotona princeps	91.78	0.00e+00	686.00
IUUC-Ont-071410	Oreochromis niloticus	75.57	1.00e-164	572.00
IUUC-Oan-073304	Ornithorhynchus anatinus	95.10	9.00e-170	588.00
IUUC-Ocu-074783	Oryctolagus cuniculus	91.58	0.00e+00	702.00
IUUC-Opu-083278	Oryza punctata	42.11	1.90e-01	29.30
IUUC-Ola-086808	Oryzias latipes	72.38	7.00e-160	556.00
IUUC-Oga-088391	Otolemur garnettii	92.63	0.00e+00	712.00
IUUC-Oar-090025	Ovis aries	78.95	6.00e-166	576.00
IUUC-Ptr-090975	Pan troglodytes	92.37	0.00e+00	726.00
IUUC-Pan-092287	Papio anubis	92.37	0.00e+00	728.00
IUUC-Psi-093413	Pelodiscus sinensis	97.11	0.00e+00	751.00
IUUC-Pfo-097129	Poecilia formosa	76.20	1.00e-170	592.00
IUUC-Pab-098756	Pongo abelii	92.37	0.00e+00	726.00
IUUC-Pca-100235	Procavia capensis	81.58	0.00e+00	644.00
IUUC-Pva-102294	Pteropus vampyrus	88.42	0.00e+00	690.00
IUUC-Rno-105090	Rattus norvegicus	89.21	0.00e+00	694.00
IUUC-Sar-113697	Sorex araneus	83.85	0.00e+00	645.00
IUUC-Ssc-115958	Sus scrofa	83.86	1.00e-163	568.00
IUUC-Tgu-116559	Taeniopygia guttata	95.00	0.00e+00	726.00
IUUC-Tru-117677	Takifugu rubripes	75.70	2.00e-166	578.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.97	1.00e-163	568.00
IUUC-Tbe-127931	Tupaia belangeri	90.51	1.00e-175	608.00
IUUC-Ttr-128993	Tursiops truncatus	83.16	0.00e+00	637.00
IUUC-Xtr-132543	Xenopus tropicalis	87.93	0.00e+00	689.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence