iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046788

UUCD1 version

UUC-HoS-00396

Ensembl Protein ID

ENSP00000233741.4

UniProt Accession

Q9NW38; Q6GU60; FANCL_HUMAN

Genbank Protein ID

BAA91548.1; AAY15020.1; AAH09042.1; AAH54517.1; ENSP00000233741

Protein Name

E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; RING-type E3 ubiquitin transferase FANCL

Genbank Nucleotide ID

AK001197; AC007250; BC009042; BC054517; BC037570

Gene Name

FANCL; PHF9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000115392.11	ENST00000403295.7	ENSP00000386097.3
ENSG00000115392.11	ENST00000233741.8	ENSP00000233741.4
ENSG00000115392.11	ENST00000402135.7	ENSP00000385021.3
ENSG00000115392.11	ENST00000403676.5	ENSP00000384046.1
ENSG00000115392.11	ENST00000449070.5	ENSP00000401280.1
ENSG00000115392.11	ENST00000446381.5	ENSP00000390991.1
ENSG00000115392.11	ENST00000427708.6	ENSP00000400969.2
ENSG00000115392.11	ENST00000417361.1	ENSP00000389448.1
ENSG00000115392.11	ENST00000481670.2	ENSP00000483263.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19622404; 19405097; 19805513; 21229326

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.024	16.8	307	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.....kdgplvlp.CgHvfhadClqkw.....pglknssskefr.....CPlC 45
           C iC+         d+++ ++ Cg  fh+ Cl+ w           s+++f+     CP+C
   Q: 307  CGICYAYQldgtiPDQVCDNSqCGQPFHQICLYEWlrgllT-----SRQSFNiifgeCPYC 362
           9999887766666334887778*************543332.....44444355555**** PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.

Protein Sequence
(Fasta)

MAVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN ARLLCSWQLR 60
TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE LYALPPPPQF YSSLIEEIGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCATGTGC AGGACCCAGC AGGTCTAGAG CTTTTCTGTG TTTCTCCGGA CTTCGAGCCA 60
TGGCGGTGAC GGAAGCGAGC CTGTTGCGCC AGTGCCCCCT GCTTCTGCCC CAGAACCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0923--Fanconi anemia
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR026848--Fancl
IPR026850--FANCL_C
IPR019162--FancL_WD-rpt_cont_dom
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF11793--FANCL_C
PF09765--WD-3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016604--C:nuclear body
GO:0005635--C:nuclear envelope
GO:0005654--C:nucleoplasm
GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0007276--P:gamete generation
GO:0036297--P:interstrand cross-link repair
GO:0006513--P:protein monoubiquitination
GO:0042127--P:regulation of cell proliferation

KEGG

hsa:55120

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000947	Aegilops tauschii	34.40	2.00e-30	127.00
IUUC-Aml-002195	Ailuropoda melanoleuca	91.51	0.00e+00	716.00
IUUC-Atr-002781	Amborella trichopoda	31.42	1.00e-54	206.00
IUUC-Apl-004169	Anas platyrhynchos	69.71	4.00e-151	527.00
IUUC-Aca-004265	Anolis carolinensis	72.36	1.00e-166	578.00
IUUC-Aly-005687	Arabidopsis lyrata	32.30	2.00e-45	175.00
IUUC-Ath-007450	Arabidopsis thaliana	32.99	3.00e-45	175.00
IUUC-Ame-011485	Astyanax mexicanus	61.41	2.00e-140	492.00
IUUC-Bta-012445	Bos taurus	87.70	0.00e+00	662.00
IUUC-Bol-015164	Brassica oleracea	32.43	3.00e-46	178.00
IUUC-Bra-017917	Brassica rapa	33.78	3.00e-48	185.00
IUUC-Cja-019671	Callithrix jacchus	92.89	0.00e+00	723.00
IUUC-Cfa-020724	Canis familiaris	87.86	0.00e+00	669.00
IUUC-Cpo-022262	Cavia porcellus	87.70	0.00e+00	686.00
IUUC-Cre-022596	Chlamydomonas reinhardtii	52.94	2.00e-12	66.60
IUUC-Csa-023404	Chlorocebus sabaeus	96.80	0.00e+00	754.00
IUUC-Cho-024948	Choloepus hoffmanni	77.98	8.00e-169	586.00
IUUC-Cin-025665	Ciona intestinalis	35.51	1.00e-68	253.00
IUUC-Csv-026047	Ciona savignyi	34.09	1.00e-69	256.00
IUUC-Cme-027255	Cyanidioschyzon merolae	30.03	1.00e-43	170.00
IUUC-Dre-027613	Danio rerio	59.50	1.00e-138	485.00
IUUC-Dno-029829	Dasypus novemcinctus	91.20	0.00e+00	703.00
IUUC-Dor-031075	Dipodomys ordii	75.60	1.00e-161	562.00
IUUC-Dme-031934	Drosophila melanogaster	27.60	1.00e-17	84.00
IUUC-Eca-033981	Equus caballus	91.55	0.00e+00	657.00
IUUC-Eeu-034830	Erinaceus europaeus	83.02	0.00e+00	638.00
IUUC-Fca-036219	Felis catus	88.33	0.00e+00	682.00
IUUC-Fal-037306	Ficedula albicollis	66.39	2.00e-152	531.00
IUUC-Gmo-039666	Gadus morhua	47.19	7.00e-95	340.00
IUUC-Gga-040220	Gallus gallus	70.46	1.00e-161	562.00
IUUC-Gac-042420	Gasterosteus aculeatus	56.40	7.00e-123	433.00
IUUC-Ggo-044566	Gorilla gorilla	98.68	0.00e+00	773.00
IUUC-Hvu-047570	Hordeum vulgare	36.49	2.00e-50	192.00
IUUC-Itr-047954	Ictidomys tridecemlineatus	89.45	0.00e+00	701.00
IUUC-Lch-050066	Latimeria chalumnae	71.51	3.00e-155	541.00
IUUC-Loc-052217	Lepisosteus oculatus	69.30	2.00e-150	525.00
IUUC-Mcc-055354	Macaca mulatta	96.80	0.00e+00	756.00
IUUC-Meu-056714	Macropus eugenii	72.59	5.00e-143	500.00
IUUC-Mga-060000	Meleagris gallopavo	67.68	5.00e-152	530.00
IUUC-Mmr-061723	Microcebus murinus	94.39	0.00e+00	739.00
IUUC-Mdo-062984	Monodelphis domestica	83.16	0.00e+00	671.00
IUUC-Mmu-064139	Mus musculus	79.41	2.00e-170	592.00
IUUC-Mac-065662	Musa acuminata	32.61	3.00e-48	186.00
IUUC-Mpu-066812	Mustela putorius furo	91.25	0.00e+00	709.00
IUUC-Mlu-067545	Myotis lucifugus	88.50	0.00e+00	701.00
IUUC-Nle-069513	Nomascus leucogenys	87.96	0.00e+00	682.00
IUUC-Opr-070501	Ochotona princeps	72.73	7.00e-155	540.00
IUUC-Ont-072646	Oreochromis niloticus	61.62	6.00e-132	463.00
IUUC-Oan-073161	Ornithorhynchus anatinus	78.55	2.00e-176	611.00
IUUC-Ocu-074746	Oryctolagus cuniculus	88.65	0.00e+00	676.00
IUUC-Obr-076053	Oryza brachyantha	36.43	2.00e-50	193.00
IUUC-Ogl-077717	Oryza glaberrima	32.95	7.00e-40	157.00
IUUC-Oin-079089	Oryza indica	34.41	2.00e-48	186.00
IUUC-Ome-081316	Oryza meridionalis	32.97	2.00e-44	172.00
IUUC-Oni-082916	Oryza nivara	32.18	4.00e-42	165.00
IUUC-Opu-083751	Oryza punctata	35.14	4.00e-50	191.00
IUUC-Osa-085519	Oryza sativa	34.77	3.00e-49	189.00
IUUC-Ola-086369	Oryzias latipes	61.08	4.00e-140	491.00
IUUC-Oga-088349	Otolemur garnettii	89.30	0.00e+00	704.00
IUUC-Oar-090434	Ovis aries	86.90	0.00e+00	657.00
IUUC-Ptr-090459	Pan troglodytes	97.89	0.00e+00	766.00
IUUC-Pan-092544	Papio anubis	90.96	0.00e+00	703.00
IUUC-Psi-093343	Pelodiscus sinensis	71.51	7.00e-156	543.00
IUUC-Pma-094525	Petromyzon marinus	57.65	5.00e-126	444.00
IUUC-Ppa-095236	Physcomitrella patens	39.30	2.00e-75	275.00
IUUC-Pfo-096567	Poecilia formosa	63.10	1.00e-137	482.00
IUUC-Pab-098472	Pongo abelii	98.93	0.00e+00	773.00
IUUC-Pca-100979	Procavia capensis	76.50	4.00e-92	331.00
IUUC-Ppe-101756	Prunus persica	33.33	7.00e-49	187.00
IUUC-Pva-102760	Pteropus vampyrus	89.30	0.00e+00	659.00
IUUC-Rno-105013	Rattus norvegicus	79.68	0.00e+00	633.00
IUUC-Sha-107358	Sarcophilus harrisii	83.72	4.00e-180	623.00
IUUC-Sit-110352	Setaria italica	37.41	2.00e-52	199.00
IUUC-Sly-111509	Solanum lycopersicum	34.64	2.00e-52	199.00
IUUC-Sar-113212	Sorex araneus	77.63	4.00e-161	560.00
IUUC-Sbi-114129	Sorghum bicolor	36.59	3.00e-48	186.00
IUUC-Ssc-116109	Sus scrofa	86.32	4.00e-167	580.00
IUUC-Tgu-117065	Taeniopygia guttata	68.75	1.00e-158	552.00
IUUC-Tru-117934	Takifugu rubripes	59.36	1.00e-138	486.00
IUUC-Tsy-119196	Tarsius syrichta	83.02	1.00e-174	605.00
IUUC-Tni-120320	Tetraodon nigroviridis	57.03	1.00e-129	456.00
IUUC-Tca-121021	Theobroma cacao	32.38	8.00e-51	193.00
IUUC-Tae-123568	Triticum aestivum	37.91	1.00e-52	200.00
IUUC-Tur-126008	Triticum urartu	37.10	3.00e-46	178.00
IUUC-Tbe-127837	Tupaia belangeri	73.39	7.00e-144	503.00
IUUC-Ttr-129133	Tursiops truncatus	80.75	5.00e-179	620.00
IUUC-Vpa-130296	Vicugna pacos	83.24	1.00e-170	592.00
IUUC-Vvi-131575	Vitis vinifera	34.15	3.00e-11	61.60
IUUC-Xtr-131991	Xenopus tropicalis	60.22	6.00e-136	477.00
IUUC-Xma-133080	Xiphophorus maculatus	62.16	3.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence