iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088140

Ensembl Protein ID

ENSOGAP00000003714.2

UniProt Accession

H0WPB4; H0WPB4_OTOGA

Genbank Protein ID

ENSOGAP00000003714

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAQR03125253

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000004157.2	ENSOGAT00000004165.2	ENSOGAP00000003714.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.90e-29	99.3	1245	1298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++ +  wiC+ C ++
   Q: 1245 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRRRrhWICSACVRC 1298
           58********************************.55554444444******876 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGSGA ERVRVPLRRG GGAAGPGGAE 60
PGEDTALRCL LGLRRGLHRL RRLCAGPRVQ RGRGRGRGRG WGPSRSSVPE EESSDGESDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGGCGG CGGCAGTTGC CCCGGGCCTG GCTCCGCGCG GGGCCGCTTC 60
CCGGGCCGGC CGCGGGGCTC CGGCGGGGGC GGGGGCCGCG GCGGACGGGG CAGCGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	91.96	0.00e+00	3236.00
IUUC-Aca-004718	Anolis carolinensis	57.32	0.00e+00	1471.00
IUUC-Ame-010705	Astyanax mexicanus	43.82	0.00e+00	920.00
IUUC-Bta-013578	Bos taurus	94.15	0.00e+00	2950.00
IUUC-Bdi-014882	Brachypodium distachyon	33.33	2.00e-27	117.00
IUUC-Bra-017422	Brassica rapa	33.50	1.00e-27	118.00
IUUC-Cja-019138	Callithrix jacchus	91.82	0.00e+00	3282.00
IUUC-Cfa-020020	Canis familiaris	93.55	0.00e+00	3175.00
IUUC-Cpo-021552	Cavia porcellus	90.23	0.00e+00	3224.00
IUUC-Csa-024216	Chlorocebus sabaeus	94.20	0.00e+00	3318.00
IUUC-Cho-024565	Choloepus hoffmanni	76.27	3.00e-167	583.00
IUUC-Dre-027440	Danio rerio	44.44	0.00e+00	907.00
IUUC-Dno-029583	Dasypus novemcinctus	94.31	0.00e+00	3076.00
IUUC-Dor-030903	Dipodomys ordii	87.66	0.00e+00	2177.00
IUUC-Dme-032023	Drosophila melanogaster	47.85	1.00e-93	340.00
IUUC-Eca-034026	Equus caballus	93.81	0.00e+00	1964.00
IUUC-Eeu-034687	Erinaceus europaeus	94.94	0.00e+00	1127.00
IUUC-Fca-036311	Felis catus	92.19	0.00e+00	3281.00
IUUC-Gmo-039265	Gadus morhua	45.16	0.00e+00	817.00
IUUC-Gac-042202	Gasterosteus aculeatus	47.34	0.00e+00	745.00
IUUC-Ggo-044791	Gorilla gorilla	93.70	0.00e+00	2144.00
IUUC-Hsa-046988	Homo sapiens	93.84	0.00e+00	3231.00
IUUC-Hvu-047762	Hordeum vulgare	36.57	3.00e-20	93.20
IUUC-Itr-048907	Ictidomys tridecemlineatus	90.75	0.00e+00	3358.00
IUUC-Lpe-051476	Leersia perrieri	31.51	3.00e-24	107.00
IUUC-Loc-052252	Lepisosteus oculatus	54.03	0.00e+00	782.00
IUUC-Laf-053703	Loxodonta africana	91.77	0.00e+00	2169.00
IUUC-Mcc-054782	Macaca mulatta	92.60	0.00e+00	2529.00
IUUC-Meu-056046	Macropus eugenii	79.84	0.00e+00	1886.00
IUUC-Mmr-061316	Microcebus murinus	92.43	0.00e+00	2895.00
IUUC-Mdo-062648	Monodelphis domestica	80.06	0.00e+00	2001.00
IUUC-Mmu-063579	Mus musculus	89.96	0.00e+00	3288.00
IUUC-Mac-064935	Musa acuminata	32.02	7.00e-30	125.00
IUUC-Mpu-066710	Mustela putorius furo	93.34	0.00e+00	3238.00
IUUC-Mlu-067559	Myotis lucifugus	90.97	0.00e+00	2458.00
IUUC-Nle-070085	Nomascus leucogenys	91.28	0.00e+00	2196.00
IUUC-Opr-071148	Ochotona princeps	88.18	0.00e+00	3197.00
IUUC-Ont-071626	Oreochromis niloticus	44.87	0.00e+00	898.00
IUUC-Ocu-074475	Oryctolagus cuniculus	90.93	0.00e+00	3147.00
IUUC-Obr-076458	Oryza brachyantha	34.48	4.00e-28	119.00
IUUC-Ogl-077851	Oryza glaberrima	36.26	3.00e-28	120.00
IUUC-Ogu-078706	Oryza glumaepatula	36.26	2.00e-28	121.00
IUUC-Oin-079802	Oryza indica	31.43	2.00e-23	103.00
IUUC-Osa-085421	Oryza sativa	36.26	4.00e-28	119.00
IUUC-Ola-086609	Oryzias latipes	49.08	0.00e+00	758.00
IUUC-Oar-089447	Ovis aries	93.09	0.00e+00	2045.00
IUUC-Ptr-090902	Pan troglodytes	93.84	0.00e+00	3249.00
IUUC-Pan-091930	Papio anubis	94.11	0.00e+00	3322.00
IUUC-Ppa-095221	Physcomitrella patens	36.06	1.00e-30	128.00
IUUC-Pfo-096884	Poecilia formosa	48.10	0.00e+00	783.00
IUUC-Pab-098404	Pongo abelii	83.26	0.00e+00	2436.00
IUUC-Pop-099585	Populus trichocarpa	33.50	1.00e-26	115.00
IUUC-Pca-100949	Procavia capensis	85.09	0.00e+00	1257.00
IUUC-Ppe-101920	Prunus persica	33.01	9.00e-28	119.00
IUUC-Pva-102634	Pteropus vampyrus	92.72	0.00e+00	3308.00
IUUC-Rno-105870	Rattus norvegicus	89.57	0.00e+00	3350.00
IUUC-Sit-110552	Setaria italica	34.33	7.00e-29	122.00
IUUC-Sar-113289	Sorex araneus	90.05	0.00e+00	1768.00
IUUC-Ssc-115509	Sus scrofa	91.63	0.00e+00	3414.00
IUUC-Tru-117736	Takifugu rubripes	44.60	0.00e+00	828.00
IUUC-Tca-121624	Theobroma cacao	32.67	1.00e-27	118.00
IUUC-Tae-125629	Triticum aestivum	36.57	3.00e-20	93.60
IUUC-Tbe-127825	Tupaia belangeri	88.94	0.00e+00	1433.00
IUUC-Ttr-128754	Tursiops truncatus	91.62	0.00e+00	1239.00
IUUC-Xtr-132838	Xenopus tropicalis	49.28	0.00e+00	1010.00
IUUC-Xma-133119	Xiphophorus maculatus	42.83	0.00e+00	969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence