iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098404

Ensembl Protein ID

ENSPPYP00000011057.1

UniProt Accession

H2NYH6; H2NYH6_PONAB

Genbank Protein ID

ENSPPYP00000011057

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ABGA01013206

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000009877.2	ENSPPYT00000011489.1	ENSPPYP00000011057.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.70e-18	65.5	1169	1222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1169 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1222
           58********************************.88888877777******876 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MGEEAGGSYP GPGSARGRFP SRPRGAGGGG GRGGRGNGAE RVRVALRRGG SATGPGGAEP 60
GEDTALLRLL GLRRGLRRLR RLWAGPRVQR GRGRGRGRGW GPSRGCVPEE ESSDGESDEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAGG AGGCGGCGGC GGCAGTTACC CCGGGCCTGG GTCCGCGCGG GGGCCGCTTC 60
CCGAGCCGAC CGCGGGGCGC CGGCGGGGGC GGGGGCCGCG GCGGACGAGG CAACGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	82.72	0.00e+00	2430.00
IUUC-Aca-004718	Anolis carolinensis	56.57	0.00e+00	1206.00
IUUC-Bta-013578	Bos taurus	92.72	0.00e+00	1730.00
IUUC-Cja-019138	Callithrix jacchus	97.21	0.00e+00	1912.00
IUUC-Cfa-020020	Canis familiaris	83.45	0.00e+00	2349.00
IUUC-Cpo-021552	Cavia porcellus	91.21	0.00e+00	1857.00
IUUC-Csa-024216	Chlorocebus sabaeus	98.24	0.00e+00	1950.00
IUUC-Cho-024565	Choloepus hoffmanni	76.50	5.00e-164	572.00
IUUC-Dno-029583	Dasypus novemcinctus	82.38	0.00e+00	2462.00
IUUC-Dor-030903	Dipodomys ordii	72.58	0.00e+00	1414.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	1.00e-92	337.00
IUUC-Eca-034026	Equus caballus	90.25	0.00e+00	1001.00
IUUC-Eeu-034687	Erinaceus europaeus	94.92	0.00e+00	955.00
IUUC-Fca-036311	Felis catus	82.87	0.00e+00	2433.00
IUUC-Ggo-044791	Gorilla gorilla	96.58	0.00e+00	1110.00
IUUC-Hsa-046988	Homo sapiens	98.56	0.00e+00	1931.00
IUUC-Itr-048907	Ictidomys tridecemlineatus	80.62	0.00e+00	2525.00
IUUC-Laf-053703	Loxodonta africana	90.32	0.00e+00	1018.00
IUUC-Mcc-054782	Macaca mulatta	98.52	0.00e+00	1154.00
IUUC-Meu-056046	Macropus eugenii	64.73	0.00e+00	1306.00
IUUC-Mmr-061316	Microcebus murinus	79.44	0.00e+00	2281.00
IUUC-Mdo-062648	Monodelphis domestica	69.06	0.00e+00	1405.00
IUUC-Mmu-063579	Mus musculus	79.94	0.00e+00	2478.00
IUUC-Mpu-066710	Mustela putorius furo	82.64	0.00e+00	2417.00
IUUC-Mlu-067559	Myotis lucifugus	81.01	0.00e+00	2399.00
IUUC-Nle-070085	Nomascus leucogenys	98.50	0.00e+00	940.00
IUUC-Opr-071148	Ochotona princeps	80.24	0.00e+00	2417.00
IUUC-Ocu-074475	Oryctolagus cuniculus	79.93	0.00e+00	2515.00
IUUC-Oga-088140	Otolemur garnettii	83.10	0.00e+00	2453.00
IUUC-Oar-089447	Ovis aries	92.18	0.00e+00	957.00
IUUC-Ptr-090902	Pan troglodytes	98.32	0.00e+00	1941.00
IUUC-Pan-091930	Papio anubis	98.32	0.00e+00	1952.00
IUUC-Pca-100949	Procavia capensis	93.83	0.00e+00	961.00
IUUC-Pva-102634	Pteropus vampyrus	81.36	0.00e+00	2449.00
IUUC-Rno-105870	Rattus norvegicus	79.30	0.00e+00	2492.00
IUUC-Sar-113289	Sorex araneus	91.46	0.00e+00	977.00
IUUC-Ssc-115509	Sus scrofa	93.44	0.00e+00	1783.00
IUUC-Tni-119794	Tetraodon nigroviridis	62.16	7.00e-152	532.00
IUUC-Tbe-127825	Tupaia belangeri	88.57	0.00e+00	862.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence