iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000003964.7	ENSRNOT00000086039.1	ENSRNOP00000069742.1
ENSRNOG00000003964.7	ENSRNOT00000005376.5	ENSRNOP00000005376.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.70e-11	42.3	165	242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlp.sGitydrssIekwlasggk.....tcPvtrqpl...teedlvPnltlrrliqawceen 72
             f+CpI+   M+ Pv  + +G+ty+ ++I + ++s++k      cP+ + +    + +dl+P  +lrr i+++ +++
   Q: 165  TNFICPITQLEMKKPVKNKmCGHTYEEEAIVRMIESKHKrkkkaCCPKIGCSHtdmRMSDLIPDEALRRAIESHNKKK 242
           57********************************99999999998887654442227799************998776 PP

Organism

Rattus norvegicus

Functional Description
(View)

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).

Protein Sequence
(Fasta)

MPGRSSTNSG STRYISFSGV ESALSSLKTF QSCISSGMDT VSSVALDLVE TQTEVSSEYS 60
MDKAMVEFAK MDRELNHYVK AVQSTINHVK EERPEKVPDL KLLVEKKFLA LQDKNSDADF 120

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Nucleotide Sequence
(Fasta)

GACGCAGAGC GCGCGCGGGG CGTTTCAGCC ACTGGAGAAG TAGGCTGAGG AAAGGAATCG 60
GGGTCTGGGT GTGCGACGTT CGGCAAGATA TCGCTGAGCT AGGTGGGACA GCCAGGTAAG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR026846--Nse2(Mms21)
IPR003613--Ubox_domain
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51044--ZF_SP_RING

Pfam

PF11789--zf-Nse

SMART

SM00504--Ubox

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0016605--C:PML body
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0090398--P:cellular senescence
GO:0000724--P:double-strand break repair via homologous recombination
GO:0007067--P:mitotic nuclear division
GO:0034184--P:positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000722--P:telomere maintenance via recombination

KEGG

rno:299957

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001627	Ailuropoda melanoleuca	87.04	1.00e-108	385.00
IUUC-Atr-002438	Amborella trichopoda	32.29	2.00e-06	46.20
IUUC-Apl-004091	Anas platyrhynchos	64.21	3.00e-31	126.00
IUUC-Aca-004433	Anolis carolinensis	51.75	3.00e-70	257.00
IUUC-Aly-006133	Arabidopsis lyrata	26.15	5.00e-08	51.20
IUUC-Ath-007424	Arabidopsis thaliana	26.80	3.00e-09	55.10
IUUC-Ago-007852	Ashbya gossypii	29.73	1.00e-07	49.70
IUUC-Acl-008011	Aspergillus clavatus	32.56	4.00e-03	36.60
IUUC-Afl-008461	Aspergillus flavus	46.67	7.00e-03	35.40
IUUC-Afu-008893	Aspergillus fumigatus	32.56	1.00e-03	38.50
IUUC-Ani-009414	Aspergillus nidulans	31.82	4.00e-04	39.70
IUUC-Ang-009587	Aspergillus niger	40.00	3.00e-03	37.00
IUUC-Ate-010326	Aspergillus terreus	34.88	6.00e-03	37.00
IUUC-Ame-010902	Astyanax mexicanus	41.63	7.00e-47	180.00
IUUC-Bgr-012088	Blumeria graminis	25.81	9.00e-06	44.70
IUUC-Bta-013397	Bos taurus	88.07	2.00e-70	257.00
IUUC-Bci-013738	Botrytis cinerea	25.26	1.00e-05	44.30
IUUC-Cel-018588	Caenorhabditis elegans	32.26	1.10e-02	33.10
IUUC-Cja-019246	Callithrix jacchus	89.47	3.00e-110	390.00
IUUC-Cpo-021670	Cavia porcellus	88.65	1.00e-99	355.00
IUUC-Csa-023982	Chlorocebus sabaeus	84.21	2.00e-101	361.00
IUUC-Cin-025127	Ciona intestinalis	24.31	5.00e-16	77.80
IUUC-Cgl-026430	Colletotrichum gloeosporioides	32.20	6.00e-07	48.50
IUUC-Cne-026806	Cryptococcus neoformans	28.83	2.00e-09	56.20
IUUC-Cme-027175	Cyanidioschyzon merolae	29.58	7.00e-06	44.70
IUUC-Dre-028325	Danio rerio	36.92	6.00e-34	137.00
IUUC-Dno-029735	Dasypus novemcinctus	89.47	6.00e-121	426.00
IUUC-Dor-030454	Dipodomys ordii	73.66	1.00e-78	285.00
IUUC-Dme-031971	Drosophila melanogaster	26.96	1.00e-07	50.10
IUUC-Ete-032838	Echinops telfairi	65.16	5.00e-53	199.00
IUUC-Eca-034371	Equus caballus	87.45	4.00e-120	423.00
IUUC-Eeu-035258	Erinaceus europaeus	86.02	3.00e-82	297.00
IUUC-Fca-035576	Felis catus	87.45	5.00e-107	380.00
IUUC-Fal-037038	Ficedula albicollis	56.22	2.00e-75	275.00
IUUC-Fox-037843	Fusarium oxysporum	31.43	2.00e-05	43.10
IUUC-Fso-038272	Fusarium solani	31.25	4.00e-06	45.80
IUUC-Ggr-040059	Gaeumannomyces graminis	28.57	2.00e-06	46.60
IUUC-Gga-040737	Gallus gallus	44.40	1.00e-57	216.00
IUUC-Gac-042591	Gasterosteus aculeatus	43.22	1.00e-44	172.00
IUUC-Gma-043177	Glycine max	24.87	3.00e-07	48.90
IUUC-Ggo-045206	Gorilla gorilla	84.21	1.00e-102	365.00
IUUC-Hsa-046704	Homo sapiens	84.65	2.00e-103	367.00
IUUC-Hvu-047252	Hordeum vulgare	25.69	3.00e-05	42.00
IUUC-Itr-048972	Ictidomys tridecemlineatus	88.37	5.00e-46	176.00
IUUC-Kpa-049181	Komagataella pastoris	26.09	1.00e-09	57.00
IUUC-Loc-052687	Lepisosteus oculatus	41.41	3.00e-43	168.00
IUUC-Lma-053255	Leptosphaeria maculans	30.56	5.00e-06	45.80
IUUC-Laf-054270	Loxodonta africana	84.21	6.00e-113	399.00
IUUC-Mcc-054757	Macaca mulatta	83.96	2.00e-80	291.00
IUUC-Mor-057028	Magnaporthe oryzae	23.45	5.00e-07	48.90
IUUC-Mpo-057462	Magnaporthe poae	28.57	3.00e-07	49.70
IUUC-Mtr-058011	Medicago truncatula	25.93	3.00e-10	58.50
IUUC-Mga-059215	Meleagris gallopavo	66.67	2.00e-33	133.00
IUUC-Mvi-060511	Microbotryum violaceum	32.47	6.00e-07	48.50
IUUC-Mmr-061584	Microcebus murinus	85.43	2.00e-106	378.00
IUUC-Mdo-061863	Monodelphis domestica	54.70	4.00e-74	270.00
IUUC-Mmu-064413	Mus musculus	97.17	3.00e-126	444.00
IUUC-Mac-065639	Musa acuminata	30.69	5.00e-06	44.70
IUUC-Mpu-066092	Mustela putorius furo	74.18	7.00e-104	369.00
IUUC-Mlu-068198	Myotis lucifugus	88.44	1.00e-118	418.00
IUUC-Nfi-068508	Neosartorya fischeri	27.94	7.00e-04	38.50
IUUC-Ncr-068773	Neurospora crassa	31.03	4.00e-06	45.80
IUUC-Nle-070109	Nomascus leucogenys	85.53	1.00e-105	375.00
IUUC-Opr-070540	Ochotona princeps	61.48	4.00e-63	234.00
IUUC-Ont-071575	Oreochromis niloticus	43.04	7.00e-46	177.00
IUUC-Oan-072777	Ornithorhynchus anatinus	76.19	4.00e-24	102.00
IUUC-Ocu-074730	Oryctolagus cuniculus	90.22	6.00e-110	389.00
IUUC-Oga-087925	Otolemur garnettii	88.16	2.00e-100	358.00
IUUC-Oar-090138	Ovis aries	73.55	5.00e-97	347.00
IUUC-Ptr-091582	Pan troglodytes	84.65	2.00e-103	367.00
IUUC-Pan-092890	Papio anubis	84.21	2.00e-101	361.00
IUUC-Psi-093714	Pelodiscus sinensis	55.33	2.00e-76	278.00
IUUC-Pma-094198	Petromyzon marinus	32.37	3.00e-21	94.00
IUUC-Pno-094931	Phaeosphaeria nodorum	32.47	4.00e-05	42.70
IUUC-Pab-098005	Pongo abelii	84.21	4.00e-103	367.00
IUUC-Pop-099559	Populus trichocarpa	24.00	8.00e-07	47.80
IUUC-Pca-100368	Procavia capensis	66.67	1.00e-63	235.00
IUUC-Ppe-101873	Prunus persica	24.19	3.00e-08	52.00
IUUC-Pva-102951	Pteropus vampyrus	88.66	2.00e-112	397.00
IUUC-Pte-104390	Pyrenophora teres	38.46	1.00e-05	44.30
IUUC-Pyt-104633	Pyrenophora triticirepentis	38.46	1.00e-05	44.30
IUUC-Sha-107586	Sarcophilus harrisii	69.29	3.00e-41	160.00
IUUC-Sja-107983	Schizosaccharomyces japonicus	34.78	1.00e-10	60.10
IUUC-Spo-108327	Schizosaccharomyces pombe	29.67	6.00e-05	41.20
IUUC-Ssl-108555	Sclerotinia sclerotiorum	26.37	3.00e-06	46.60
IUUC-Sit-109919	Setaria italica	29.27	8.00e-07	47.80
IUUC-Sly-111667	Solanum lycopersicum	24.69	4.00e-05	42.00
IUUC-Sar-113609	Sorex araneus	85.90	2.00e-100	358.00
IUUC-Sre-115187	Sporisorium reilianum	33.33	1.00e-06	47.00
IUUC-Tgu-116472	Taeniopygia guttata	53.74	6.00e-69	253.00
IUUC-Tru-117771	Takifugu rubripes	42.50	1.00e-44	173.00
IUUC-Tni-119821	Tetraodon nigroviridis	39.15	4.00e-45	174.00
IUUC-Tca-121272	Theobroma cacao	28.77	8.00e-06	43.90
IUUC-Tre-122049	Trichoderma reesei	32.93	8.00e-09	54.70
IUUC-Tvi-122642	Trichoderma virens	30.49	3.00e-07	49.30
IUUC-Tme-126988	Tuber melanosporum	31.34	3.00e-06	46.20
IUUC-Tbe-127676	Tupaia belangeri	88.83	4.00e-91	327.00
IUUC-Ttr-128602	Tursiops truncatus	86.23	7.00e-108	382.00
IUUC-Vpa-130510	Vicugna pacos	88.66	7.00e-110	389.00
IUUC-Vvi-131486	Vitis vinifera	29.95	4.00e-11	61.60
IUUC-Yli-134676	Yarrowia lipolytica	29.41	3.00e-05	42.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence