iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.00e-40	133.3	395	432
UBD/Beta-Prp	2.90e-62	210.5	115	339

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d+v+ ++f ++ ++l+++s D+t ++W + +g + 
   Q: 395  GHSDEVSKVCFsPSgCMLLTASADNTARLWLTESGQCS 432
           8***********666***************88888776 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.......................vtavkfspdgkilvtgseDrtikvwdl 81
           ++h+ ++t v f ++++ ++tgs+d+t  v +++t ++ + lsgh++                         t+ +++ ++  +vtgs D+t+kvw+ 
   Q: 115  NSHILPLTNVSFDRSGERCLTGSYDRTCHVINTQTAQVEHILSGHDNVvfsvgfnfphwlvylqsggsgnnLTTFSIIFSD-KIVTGSFDGTAKVWSA 211
           68999*****************************************99***********************8888888886.7*************** PP
   S: 82   stgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
            +g+ + t+ gh++++++ +f+p +g++++++s d  +r++d+et  +l+  l+ h + v  ++++ dg++l +Gs D    +Wd+++++l ++l+g 
   Q: 212  TSGQSLCTFYGHTAELVAAEFHPvDGKSIATASLDGSARIYDVETSHELQ-QLTHHGAEVIAARFNRDGQMLLTGSFDHSAAIWDVRSKSLGHQLRG- 307
           ***********************999************************.*********************************************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlq 210
           h        ++ +g  +++gsld+t ++wd +
   Q: 308  HSAELSNCVWNFSGSLIATGSLDNTARIWDTR 339
           ******************************87 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSATKIFLRY YPPGLAVNYK TTKGNERLRH FDLLDLDSKT NIEPLADRIL LQTLAEAEEE 60
QSPADLEKSP PPRPVSGSVA RSQNAFSALK QALEKLQKKL REPVKKKFYL HKCHNSHILP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTGCCA CCAAGATCTT CCTGCGCTAC TATCCGCCAG GTGGGAAGGA TCATTAAACC 60
AAGTGCTAAG TAGCTATTGA CTATCTTGGC TTTTTCCAGG ACTGGCAGTT AACTATAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002244	Ailuropoda melanoleuca	38.76	6.00e-92	330.00
IUUC-Apl-003764	Anas platyrhynchos	40.43	2.00e-90	324.00
IUUC-Aca-005354	Anolis carolinensis	41.33	4.00e-100	357.00
IUUC-Ame-010648	Astyanax mexicanus	40.30	1.00e-92	332.00
IUUC-Bta-013294	Bos taurus	39.19	1.00e-92	332.00
IUUC-Cja-018728	Callithrix jacchus	38.12	9.00e-94	336.00
IUUC-Cfa-021122	Canis familiaris	40.04	1.00e-96	345.00
IUUC-Cpo-021472	Cavia porcellus	38.77	7.00e-88	316.00
IUUC-Cre-022946	Chlamydomonas reinhardtii	38.46	2.00e-33	135.00
IUUC-Csa-023349	Chlorocebus sabaeus	38.12	2.00e-92	332.00
IUUC-Cho-024337	Choloepus hoffmanni	30.77	4.00e-48	184.00
IUUC-Cin-025447	Ciona intestinalis	40.04	2.00e-98	351.00
IUUC-Csv-026024	Ciona savignyi	38.76	7.00e-95	339.00
IUUC-Dre-028787	Danio rerio	39.87	1.00e-94	339.00
IUUC-Dno-029788	Dasypus novemcinctus	37.18	2.00e-83	302.00
IUUC-Dor-030679	Dipodomys ordii	45.45	5.00e-39	154.00
IUUC-Ete-032844	Echinops telfairi	44.78	2.00e-48	185.00
IUUC-Eca-034088	Equus caballus	38.97	1.00e-95	342.00
IUUC-Eeu-034898	Erinaceus europaeus	42.64	2.00e-55	209.00
IUUC-Fca-036058	Felis catus	43.45	5.00e-84	303.00
IUUC-Fal-036638	Ficedula albicollis	37.95	4.00e-68	250.00
IUUC-Gmo-039010	Gadus morhua	36.79	2.00e-70	258.00
IUUC-Gga-040984	Gallus gallus	39.27	5.00e-94	337.00
IUUC-Gac-042552	Gasterosteus aculeatus	41.20	3.00e-98	350.00
IUUC-Ggo-044596	Gorilla gorilla	33.05	7.00e-65	240.00
IUUC-Hsa-046535	Homo sapiens	38.54	7.00e-94	336.00
IUUC-Itr-048672	Ictidomys tridecemlineatus	45.05	2.00e-66	244.00
IUUC-Lch-049902	Latimeria chalumnae	41.45	1.00e-100	358.00
IUUC-Loc-051919	Lepisosteus oculatus	41.88	6.00e-104	370.00
IUUC-Laf-053877	Loxodonta africana	39.61	1.00e-93	335.00
IUUC-Mcc-055010	Macaca mulatta	38.12	2.00e-92	332.00
IUUC-Meu-055980	Macropus eugenii	39.30	4.00e-68	251.00
IUUC-Mga-059883	Meleagris gallopavo	36.34	6.00e-79	286.00
IUUC-Mmr-061645	Microcebus murinus	39.65	7.00e-95	340.00
IUUC-Mdo-062166	Monodelphis domestica	40.09	2.00e-93	335.00
IUUC-Mmu-063653	Mus musculus	39.32	1.00e-96	345.00
IUUC-Mpu-066807	Mustela putorius furo	40.87	9.00e-98	349.00
IUUC-Mlu-067792	Myotis lucifugus	39.06	6.00e-93	333.00
IUUC-Nle-069067	Nomascus leucogenys	38.54	3.00e-94	337.00
IUUC-Opr-070841	Ochotona princeps	33.55	1.00e-66	245.00
IUUC-Ont-072191	Oreochromis niloticus	42.70	4.00e-101	360.00
IUUC-Oan-073649	Ornithorhynchus anatinus	44.14	1.00e-50	191.00
IUUC-Ocu-074966	Oryctolagus cuniculus	37.73	1.00e-70	259.00
IUUC-Ola-087021	Oryzias latipes	39.83	4.00e-91	327.00
IUUC-Oga-088193	Otolemur garnettii	39.45	3.00e-93	334.00
IUUC-Oar-089207	Ovis aries	39.83	6.00e-98	350.00
IUUC-Ptr-091298	Pan troglodytes	38.54	1.00e-93	335.00
IUUC-Pan-092620	Papio anubis	36.41	9.00e-66	243.00
IUUC-Psi-093232	Pelodiscus sinensis	41.11	5.00e-99	353.00
IUUC-Pno-095046	Phaeosphaeria nodorum	29.88	6.00e-27	114.00
IUUC-Pfo-096971	Poecilia formosa	40.99	3.00e-97	347.00
IUUC-Pab-098360	Pongo abelii	38.41	6.00e-93	333.00
IUUC-Pca-100384	Procavia capensis	39.19	8.00e-96	343.00
IUUC-Pva-102206	Pteropus vampyrus	38.16	3.00e-89	320.00
IUUC-Rno-105944	Rattus norvegicus	39.32	6.00e-96	343.00
IUUC-Sha-106970	Sarcophilus harrisii	40.09	2.00e-93	335.00
IUUC-Smo-108739	Selaginella moellendorffii	33.58	5.00e-37	147.00
IUUC-Ssc-115618	Sus scrofa	38.61	5.00e-90	323.00
IUUC-Tgu-117237	Taeniopygia guttata	39.65	5.00e-91	327.00
IUUC-Tbe-127358	Tupaia belangeri	46.52	2.00e-68	252.00
IUUC-Ttr-129197	Tursiops truncatus	39.83	3.00e-95	340.00
IUUC-Vpa-130692	Vicugna pacos	43.01	5.00e-85	306.00
IUUC-Xtr-132612	Xenopus tropicalis	40.64	3.00e-98	351.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence