iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027922

Ensembl Protein ID

ENSDARP00000104491.1

UniProt Accession

Q5RHD1; A5PL83; KDM7A_DANRE

Genbank Protein ID

CAI12074.1; AAI42783.1

Protein Name

Lysine-specific demethylase 7A; JmjC domain-containing histone demethylation protein 1D-A

Genbank Nucleotide ID

BX537168; BC142782

Gene Name

kdm7aa; kdm7a; jhdm1da; kdm7; si:dkey-105o6.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000018111.8	ENSDART00000123801.2	ENSDARP00000111845.2
ENSDARG00000018111.8	ENSDART00000130409.2	ENSDARP00000104491.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.00e-09	36.3	7	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC+++++ ++ ++eC++C++wfH  C++   e    + + + Cp+C+
   Q: 7    YC-VCRQPYDVNRFMIECDICKDWFHGSCVQVV-EHHAADIDVYHCPNCE 54
           8*.*****************************9.999999999******7 PP

Organism

Danio rerio

Functional Description
(View)

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).

Protein Sequence
(Fasta)

MAAAPLYCVC RQPYDVNRFM IECDICKDWF HGSCVQVVEH HAADIDVYHC PNCEPIHGPY 60
MMKKHNNWHR HDYTEPNDGT RPVQAGTAVF VKELQARSFA SGDILVQMQG NQVTKRFLEK 120

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Nucleotide Sequence
(Fasta)

ATTAGGAAGA TGGCGGCTGC CCCGCTATAC TGTGTCTGCC GGCAGCCTTA TGATGTTAAC 60
CGGTTTATGA TCGAATGCGA CATCTGTAAA GACTGGTTTC ACGGCAGGTA TGAGGATTAT 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF02373--JmjC
PF00628--PHD

SMART

SM00558--JmjC
SM00249--PHD

Gene Ontology

GO:0005634--C:nucleus
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0030901--P:midbrain development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011675	Astyanax mexicanus	67.69	0.00e+00	1011.00
IUUC-Cja-018757	Callithrix jacchus	58.48	0.00e+00	760.00
IUUC-Csa-023888	Chlorocebus sabaeus	58.68	0.00e+00	767.00
IUUC-Dno-030062	Dasypus novemcinctus	57.62	0.00e+00	746.00
IUUC-Gga-040633	Gallus gallus	78.68	1.00e-174	605.00
IUUC-Gac-041447	Gasterosteus aculeatus	71.14	0.00e+00	838.00
IUUC-Hsa-046706	Homo sapiens	58.49	0.00e+00	762.00
IUUC-Hvu-047160	Hordeum vulgare	43.40	1.00e-08	56.60
IUUC-Loc-052781	Lepisosteus oculatus	71.93	0.00e+00	886.00
IUUC-Mmr-061767	Microcebus murinus	58.56	0.00e+00	764.00
IUUC-Mdo-062778	Monodelphis domestica	57.50	0.00e+00	773.00
IUUC-Mmu-064343	Mus musculus	56.81	0.00e+00	725.00
IUUC-Mac-064704	Musa acuminata	42.59	4.00e-09	55.80
IUUC-Ogl-076925	Oryza glaberrima	35.79	2.00e-10	59.70
IUUC-Ola-087006	Oryzias latipes	59.75	0.00e+00	924.00
IUUC-Ptr-090549	Pan troglodytes	58.49	0.00e+00	762.00
IUUC-Pan-091786	Papio anubis	58.47	0.00e+00	765.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	34.39	3.00e-62	234.00
IUUC-Ssc-116137	Sus scrofa	57.59	0.00e+00	748.00
IUUC-Tru-118331	Takifugu rubripes	71.60	0.00e+00	838.00
IUUC-Tni-119870	Tetraodon nigroviridis	81.49	0.00e+00	788.00
IUUC-Ttr-129014	Tursiops truncatus	56.45	0.00e+00	721.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence