iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088353

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03141582

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010769.2	ENSOGAT00000010774.2	ENSOGAP00000009639.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.70e-15	56.9	296	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++  +e p+s +w C +C 
   Q: 296  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LQEIPSSGTWRCCSCL 341
           57*********....*******************.***************6 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MAGELRRLLR LHRTEIAVAV DSAFPLLHSL ADHDVVPEDK FQETLRLMEK EGCPQAVHAL 60
LSWLLTQDSA AILEFWRVLF KDYNLEKYGR LKPILDSFPK DVDLSQPRKG RKPPASPKAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGGCG AGCTGCGCCG CCTCCTGAGG CTGCACCGCA CCGAGATCGC TGTGGCTGTG 60
GACAGCGCCT TCCCGCTGCT GCACTCGCTG GCCGACCATG ACGTGGTCCC CGAGGACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	74.12	0.00e+00	638.00
IUUC-Aca-004543	Anolis carolinensis	62.90	1.00e-21	93.60
IUUC-Bta-012988	Bos taurus	71.14	0.00e+00	665.00
IUUC-Cja-019486	Callithrix jacchus	70.91	4.00e-102	364.00
IUUC-Cfa-021069	Canis familiaris	74.30	0.00e+00	636.00
IUUC-Cpo-021649	Cavia porcellus	71.12	5.00e-164	570.00
IUUC-Csa-023960	Chlorocebus sabaeus	78.76	0.00e+00	627.00
IUUC-Cne-026966	Cryptococcus neoformans	52.94	5.00e-12	65.90
IUUC-Dre-028583	Danio rerio	33.52	2.00e-66	246.00
IUUC-Dno-029869	Dasypus novemcinctus	65.15	5.00e-131	461.00
IUUC-Dor-030263	Dipodomys ordii	81.91	5.00e-44	171.00
IUUC-Ete-032778	Echinops telfairi	85.71	1.00e-46	181.00
IUUC-Eca-034328	Equus caballus	73.46	4.00e-180	624.00
IUUC-Fca-035400	Felis catus	71.48	4.00e-179	620.00
IUUC-Fal-036644	Ficedula albicollis	42.16	1.00e-79	290.00
IUUC-Ggo-045250	Gorilla gorilla	77.97	0.00e+00	645.00
IUUC-Hsa-046603	Homo sapiens	77.59	0.00e+00	640.00
IUUC-Hvu-047073	Hordeum vulgare	50.00	2.00e-12	68.90
IUUC-Itr-048977	Ictidomys tridecemlineatus	73.11	1.00e-177	616.00
IUUC-Lch-050310	Latimeria chalumnae	40.81	3.00e-94	338.00
IUUC-Loc-052508	Lepisosteus oculatus	40.04	1.00e-92	333.00
IUUC-Laf-054028	Loxodonta africana	67.70	4.00e-162	564.00
IUUC-Mcc-054935	Macaca mulatta	77.26	0.00e+00	665.00
IUUC-Mga-059318	Meleagris gallopavo	41.95	1.00e-51	196.00
IUUC-Mmr-061557	Microcebus murinus	65.75	3.00e-157	548.00
IUUC-Mdo-062475	Monodelphis domestica	52.16	5.00e-123	434.00
IUUC-Mmu-063994	Mus musculus	70.34	0.00e+00	698.00
IUUC-Mpu-066347	Mustela putorius furo	74.12	0.00e+00	711.00
IUUC-Mlu-068239	Myotis lucifugus	63.16	2.00e-92	332.00
IUUC-Nle-069544	Nomascus leucogenys	92.73	9.00e-25	106.00
IUUC-Opr-071199	Ochotona princeps	72.76	5.00e-70	258.00
IUUC-Ont-072571	Oreochromis niloticus	29.85	5.00e-46	178.00
IUUC-Oan-073739	Ornithorhynchus anatinus	53.11	5.00e-142	497.00
IUUC-Ola-086528	Oryzias latipes	34.85	7.00e-41	161.00
IUUC-Oar-090065	Ovis aries	73.39	1.00e-149	523.00
IUUC-Ptr-091347	Pan troglodytes	78.15	2.00e-178	619.00
IUUC-Pan-092423	Papio anubis	76.83	0.00e+00	663.00
IUUC-Psi-093798	Pelodiscus sinensis	53.28	6.00e-131	460.00
IUUC-Pfo-096145	Poecilia formosa	35.38	8.00e-30	124.00
IUUC-Pab-098369	Pongo abelii	83.03	3.00e-131	461.00
IUUC-Pca-100537	Procavia capensis	71.48	1.00e-177	616.00
IUUC-Pva-102639	Pteropus vampyrus	75.70	0.00e+00	633.00
IUUC-Rno-105285	Rattus norvegicus	71.40	0.00e+00	698.00
IUUC-Sha-107159	Sarcophilus harrisii	50.94	7.00e-128	450.00
IUUC-Sit-110355	Setaria italica	56.60	9.00e-12	66.60
IUUC-Sbi-113930	Sorghum bicolor	56.60	6.00e-12	67.00
IUUC-Ssc-115773	Sus scrofa	72.34	0.00e+00	658.00
IUUC-Tgu-116922	Taeniopygia guttata	49.40	6.00e-69	253.00
IUUC-Tru-118263	Takifugu rubripes	31.96	5.00e-59	221.00
IUUC-Tsy-119270	Tarsius syrichta	69.08	6.00e-93	334.00
IUUC-Tni-120138	Tetraodon nigroviridis	29.58	4.00e-58	219.00
IUUC-Tae-124715	Triticum aestivum	51.72	4.00e-13	70.90
IUUC-Tbe-128077	Tupaia belangeri	71.35	0.00e+00	682.00
IUUC-Ttr-128781	Tursiops truncatus	78.38	2.00e-77	283.00
IUUC-Xma-133054	Xiphophorus maculatus	29.98	2.00e-53	203.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence