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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064421
UUCD1 version UUC-MuM-00227
Ensembl Protein ID ENSMUSP00000138555.1
UniProt Accession Q9QZS2; O35941; Q541Z6; RNF4_MOUSE
Genbank Protein ID AAF00620.1; BAB31585.1; BAC41119.1; BAE27641.1; BAE30125.1; BAE34757.1; BAE35362.1; BAE35505.1; AAH03282.1; AAC53539.1
Protein Name E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4
Genbank Nucleotide ID AF169300; AK019171; AK090162; AK147057; AK151116; AK158987; AK159778; AK159949; BC003282; U95141
Gene Name Rnf4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029110.13 ENSMUST00000182709.7 ENSMUSP00000138555.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.90e-08 35.8 136 181
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf......kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++ +       +  +++ CgHvf+ +Cl       +s +++ +CP+Cr
   Q: 136  CPICMDGYseivqnGRLIVSTECGHVFCSQCL------RDSLKNANTCPTCR 181
           ********55553322255788*********9......4559*********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
 E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.
Protein Sequence
(Fasta)
MSTRNPQRKR RGGTVNSRQT QKRTRETTST PEVSLETEPI ELVETVGDEI VDLTCESLEP 60
VVVDLTHNDS VVIVEERRRP RRNGRRLRQD HADSCVVSSD DEELSRDKDV YVTTHTPRST 120
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Protein Fasta Sequence


>IUUC-Mmu-064421|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TCAAAGTGGT AATAGATGGT TTTCTCACCC AATAAAATTG CAATTTATCC TCCTAAACCG 60
GTAGAGCACG GGAGAAAAGG CGGGAGAGGC CAATAAGGGC TGAGAAGGGC GGGCCGGTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064421|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0031491--F:nucleosome binding
GO:0032184--F:SUMO polymer binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0090234--P:regulation of kinetochore assembly
GO:0090169--P:regulation of spindle assembly
GO:0046685--P:response to arsenic-containing substance
GO:0006351--P:transcription, DNA-templated
KEGG mmu:19822
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000620 Aegilops tauschii 39.34 1.00e-10 60.10
IUUC-Aml-002206 Ailuropoda melanoleuca 89.18 5.00e-84 303.00
IUUC-Atr-002771 Amborella trichopoda 35.38 4.00e-09 54.70
IUUC-Apl-004120 Anas platyrhynchos 69.27 6.00e-70 256.00
IUUC-Aca-004236 Anolis carolinensis 65.08 2.00e-62 231.00
IUUC-Ame-011555 Astyanax mexicanus 54.05 1.00e-36 145.00
IUUC-Bta-012913 Bos taurus 87.70 8.00e-84 302.00
IUUC-Bdi-014655 Brachypodium distachyon 42.62 2.00e-10 59.70
IUUC-Bol-016418 Brassica oleracea 37.70 5.00e-09 55.10
IUUC-Bra-016890 Brassica rapa 36.84 9.00e-08 50.10
IUUC-Cja-019151 Callithrix jacchus 89.36 2.00e-80 291.00
IUUC-Cfa-020868 Canis familiaris 87.50 5.00e-80 290.00
IUUC-Cpo-022249 Cavia porcellus 84.54 1.00e-73 268.00
IUUC-Csa-024125 Chlorocebus sabaeus 91.98 6.00e-84 303.00
IUUC-Cin-025749 Ciona intestinalis 40.98 1.00e-13 69.70
IUUC-Csv-026318 Ciona savignyi 40.98 7.00e-13 67.00
IUUC-Dre-028145 Danio rerio 45.62 8.00e-33 133.00
IUUC-Dno-029605 Dasypus novemcinctus 87.70 7.00e-87 312.00
IUUC-Dor-030898 Dipodomys ordii 87.70 3.00e-85 307.00
IUUC-Dme-032177 Drosophila melanogaster 42.37 1.00e-10 60.50
IUUC-Ete-032694 Echinops telfairi 80.21 4.00e-68 250.00
IUUC-Eca-033443 Equus caballus 90.91 4.00e-82 296.00
IUUC-Eeu-034603 Erinaceus europaeus 91.26 8.00e-54 201.00
IUUC-Fca-035507 Felis catus 87.70 1.00e-77 281.00
IUUC-Fal-037382 Ficedula albicollis 68.23 8.00e-65 239.00
IUUC-Gmo-038960 Gadus morhua 71.43 9.00e-19 85.50
IUUC-Gga-040493 Gallus gallus 66.14 2.00e-66 244.00
IUUC-Gac-042194 Gasterosteus aculeatus 49.66 2.00e-35 142.00
IUUC-Ggo-044726 Gorilla gorilla 91.44 4.00e-83 300.00
IUUC-Hsa-046212 Homo sapiens 91.44 4.00e-83 300.00
IUUC-Hvu-047337 Hordeum vulgare 34.18 7.00e-11 61.20
IUUC-Itr-047892 Ictidomys tridecemlineatus 91.01 2.00e-82 298.00
IUUC-Lpe-050920 Leersia perrieri 37.70 3.00e-10 58.50
IUUC-Loc-051907 Lepisosteus oculatus 46.39 1.00e-34 139.00
IUUC-Laf-054145 Loxodonta africana 83.51 9.00e-78 282.00
IUUC-Mcc-055689 Macaca mulatta 92.51 6.00e-84 302.00
IUUC-Meu-056654 Macropus eugenii 46.52 1.00e-39 155.00
IUUC-Mtr-058314 Medicago truncatula 45.45 2.00e-10 58.90
IUUC-Mga-059303 Meleagris gallopavo 68.06 7.00e-69 253.00
IUUC-Mmr-061355 Microcebus murinus 93.05 6.00e-84 302.00
IUUC-Mdo-062968 Monodelphis domestica 65.26 5.00e-65 240.00
IUUC-Mac-064573 Musa acuminata 31.68 2.00e-11 63.20
IUUC-Mpu-066522 Mustela putorius furo 89.95 8.00e-83 299.00
IUUC-Mlu-067065 Myotis lucifugus 84.21 1.00e-77 282.00
IUUC-Nle-069198 Nomascus leucogenys 89.84 1.00e-81 295.00
IUUC-Opr-071141 Ochotona princeps 86.10 4.00e-85 306.00
IUUC-Oan-073341 Ornithorhynchus anatinus 65.03 7.00e-36 142.00
IUUC-Ocu-073787 Oryctolagus cuniculus 88.14 1.00e-91 328.00
IUUC-Oba-075460 Oryza barthii 40.32 5.00e-11 61.20
IUUC-Obr-076349 Oryza brachyantha 37.70 8.00e-10 57.40
IUUC-Ogl-077094 Oryza glaberrima 40.32 5.00e-11 61.20
IUUC-Ogu-078677 Oryza glumaepatula 40.32 4.00e-11 61.60
IUUC-Oin-079992 Oryza indica 40.32 5.00e-11 61.20
IUUC-Olo-080257 Oryza longistaminata 41.94 3.00e-11 62.00
IUUC-Ome-081943 Oryza meridionalis 40.32 5.00e-11 62.00
IUUC-Oni-082671 Oryza nivara 40.32 5.00e-11 61.20
IUUC-Opu-083644 Oryza punctata 40.32 7.00e-11 60.80
IUUC-Oru-084650 Oryza rufipogon 40.32 5.00e-11 61.20
IUUC-Osa-086110 Oryza sativa 40.32 5.00e-11 61.20
IUUC-Ola-086970 Oryzias latipes 41.75 1.00e-32 132.00
IUUC-Olu-087634 Ostreococcus lucimarinus 37.29 2.00e-10 58.20
IUUC-Oga-088242 Otolemur garnettii 93.62 1.00e-93 335.00
IUUC-Oar-089469 Ovis aries 88.95 3.00e-91 327.00
IUUC-Ptr-091254 Pan troglodytes 85.56 5.00e-76 276.00
IUUC-Pan-092919 Papio anubis 92.55 1.00e-84 305.00
IUUC-Psi-093929 Pelodiscus sinensis 68.91 6.00e-67 246.00
IUUC-Pma-094118 Petromyzon marinus 48.28 1.00e-21 94.00
IUUC-Ppa-095567 Physcomitrella patens 44.26 3.00e-11 62.00
IUUC-Pfo-097412 Poecilia formosa 45.73 5.00e-33 133.00
IUUC-Pab-098424 Pongo abelii 90.91 1.00e-82 298.00
IUUC-Pca-100463 Procavia capensis 80.43 4.00e-46 177.00
IUUC-Ppe-102052 Prunus persica 34.69 7.00e-10 57.40
IUUC-Pva-102594 Pteropus vampyrus 84.06 5.00e-56 209.00
IUUC-Rno-105460 Rattus norvegicus 94.39 4.00e-87 313.00
IUUC-Sha-107487 Sarcophilus harrisii 69.43 2.00e-66 244.00
IUUC-Sit-109959 Setaria italica 36.07 4.00e-05 42.40
IUUC-Stu-112694 Solanum tuberosum 39.06 3.00e-09 55.10
IUUC-Sar-113601 Sorex araneus 85.03 5.00e-75 273.00
IUUC-Sbi-114398 Sorghum bicolor 36.07 1.00e-04 40.00
IUUC-Ssc-115911 Sus scrofa 89.84 8.00e-81 292.00
IUUC-Tgu-117264 Taeniopygia guttata 67.37 8.00e-62 229.00
IUUC-Tru-117663 Takifugu rubripes 49.37 6.00e-37 146.00
IUUC-Tsy-118883 Tarsius syrichta 86.49 5.00e-65 239.00
IUUC-Tae-124872 Triticum aestivum 39.34 1.00e-10 60.10
IUUC-Tur-126408 Triticum urartu 39.34 1.00e-10 60.10
IUUC-Ttr-128950 Tursiops truncatus 63.64 9.00e-63 233.00
IUUC-Vvi-130833 Vitis vinifera 39.71 4.00e-10 58.50
IUUC-Xtr-132879 Xenopus tropicalis 60.39 6.00e-39 153.00
IUUC-Xma-133319 Xiphophorus maculatus 44.90 8.00e-30 122.00
Created Date 25-Jun-2017

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