iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046947

UUCD1 version

UUC-HoS-00159

Ensembl Protein ID

ENSP00000301727.4

UniProt Accession

Q66K89; A8K2R4; O00146; E4F1_HUMAN

Genbank Protein ID

AAD09139.1; BAF83018.1; EAW85532.1; AAH80524.1

Protein Name

Transcription factor E4F1; E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; p120E4F; p50E4F

Genbank Nucleotide ID

U87269; AK290329; AC009065; BC080524

Gene Name

E4F1; E4F

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167967.15	ENST00000301727.8	ENSP00000301727.4
ENSG00000167967.15	ENST00000565090.5	ENSP00000456760.1
ENSG00000167967.15	ENST00000564139.5	ENSP00000457672.1
ENSG00000167967.15	ENST00000562589.5	ENSP00000456005.1
ENSG00000167967.15	ENST00000565413.1	ENSP00000454652.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	17110336; 19805293

Organism

Homo sapiens

Functional Description
(View)

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Protein Sequence
(Fasta)

MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS EEDEDDVHRC 60
GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL GQEVVPAAPG PEEPITVAHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGACAT GGTCGTAAAT CCGCCATCTT CCTGCGGCGC GTTGCGACAT GGAGGGCGCG 60
ATGGCAGTGC GGGTGACGGC CGCTCATACG GCAGAAGCCC AGGCCGAAGC CGGGCGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0341--Growth regulation
KW-0945--Host-virus interaction
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

SMART

SM00355--ZnF_C2H2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005819--C:spindle
GO:0035497--F:cAMP response element binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0016740--F:transferase activity
GO:0051301--P:cell division
GO:0008283--P:cell proliferation
GO:0006260--P:DNA replication
GO:0071850--P:mitotic cell cycle arrest
GO:0007067--P:mitotic nuclear division
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0010564--P:regulation of cell cycle process
GO:0040008--P:regulation of growth
GO:0009794--P:regulation of mitotic cell cycle, embryonic
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process

KEGG

hsa:1877

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001466	Ailuropoda melanoleuca	85.15	0.00e+00	1078.00
IUUC-Apl-004190	Anas platyrhynchos	65.55	0.00e+00	911.00
IUUC-Aca-005100	Anolis carolinensis	61.86	0.00e+00	825.00
IUUC-Ame-010704	Astyanax mexicanus	58.20	2.00e-116	412.00
IUUC-Bta-013540	Bos taurus	88.32	0.00e+00	1168.00
IUUC-Cja-018918	Callithrix jacchus	93.11	0.00e+00	1212.00
IUUC-Cfa-020601	Canis familiaris	87.83	0.00e+00	650.00
IUUC-Cpo-021573	Cavia porcellus	87.72	0.00e+00	1203.00
IUUC-Csa-023729	Chlorocebus sabaeus	96.68	0.00e+00	1209.00
IUUC-Dre-028803	Danio rerio	52.07	2.00e-103	370.00
IUUC-Dno-030072	Dasypus novemcinctus	89.47	2.00e-174	606.00
IUUC-Dor-030640	Dipodomys ordii	85.93	0.00e+00	1091.00
IUUC-Eca-034223	Equus caballus	89.41	0.00e+00	1131.00
IUUC-Fca-036268	Felis catus	85.14	0.00e+00	1097.00
IUUC-Fal-037359	Ficedula albicollis	64.53	0.00e+00	787.00
IUUC-Gmo-039016	Gadus morhua	40.83	1.00e-115	410.00
IUUC-Gga-040305	Gallus gallus	66.36	0.00e+00	904.00
IUUC-Gac-042016	Gasterosteus aculeatus	46.18	8.00e-162	564.00
IUUC-Ggo-044459	Gorilla gorilla	98.34	0.00e+00	1186.00
IUUC-Itr-048641	Ictidomys tridecemlineatus	89.82	0.00e+00	1149.00
IUUC-Lch-049557	Latimeria chalumnae	45.77	6.00e-164	571.00
IUUC-Loc-052894	Lepisosteus oculatus	50.20	0.00e+00	628.00
IUUC-Laf-053791	Loxodonta africana	84.12	0.00e+00	1119.00
IUUC-Mcc-054901	Macaca mulatta	97.19	0.00e+00	1196.00
IUUC-Meu-056299	Macropus eugenii	70.66	0.00e+00	943.00
IUUC-Mga-059323	Meleagris gallopavo	66.00	0.00e+00	917.00
IUUC-Mmr-061422	Microcebus murinus	91.03	0.00e+00	1152.00
IUUC-Mdo-061906	Monodelphis domestica	69.10	0.00e+00	960.00
IUUC-Mmu-064422	Mus musculus	87.73	0.00e+00	1177.00
IUUC-Mpu-066440	Mustela putorius furo	87.11	0.00e+00	1078.00
IUUC-Mlu-067352	Myotis lucifugus	86.82	0.00e+00	1138.00
IUUC-Nle-069201	Nomascus leucogenys	93.62	0.00e+00	655.00
IUUC-Opr-071166	Ochotona princeps	86.73	0.00e+00	1085.00
IUUC-Ont-071370	Oreochromis niloticus	46.30	3.00e-150	525.00
IUUC-Oan-072749	Ornithorhynchus anatinus	58.09	0.00e+00	674.00
IUUC-Ocu-074254	Oryctolagus cuniculus	87.96	0.00e+00	1129.00
IUUC-Ola-086897	Oryzias latipes	45.92	6.00e-156	544.00
IUUC-Oga-089179	Otolemur garnettii	88.06	0.00e+00	942.00
IUUC-Oar-090290	Ovis aries	77.60	0.00e+00	1089.00
IUUC-Ptr-091531	Pan troglodytes	95.41	0.00e+00	1127.00
IUUC-Pan-091839	Papio anubis	97.19	0.00e+00	1196.00
IUUC-Psi-093276	Pelodiscus sinensis	66.61	0.00e+00	746.00
IUUC-Pfo-096039	Poecilia formosa	50.31	6.00e-155	541.00
IUUC-Pca-100262	Procavia capensis	80.16	0.00e+00	1009.00
IUUC-Pva-102678	Pteropus vampyrus	87.30	0.00e+00	1122.00
IUUC-Rno-106036	Rattus norvegicus	86.67	0.00e+00	1174.00
IUUC-Sha-107571	Sarcophilus harrisii	70.39	0.00e+00	921.00
IUUC-Ssc-115849	Sus scrofa	88.61	0.00e+00	1118.00
IUUC-Tgu-117296	Taeniopygia guttata	65.74	0.00e+00	853.00
IUUC-Tru-118085	Takifugu rubripes	44.50	2.00e-158	552.00
IUUC-Tni-119719	Tetraodon nigroviridis	45.62	3.00e-166	578.00
IUUC-Ttr-129067	Tursiops truncatus	88.86	0.00e+00	1120.00
IUUC-Xtr-132116	Xenopus tropicalis	49.42	7.00e-167	580.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence