iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000018517.7	ENSRNOT00000092890.1	ENSRNOP00000075958.1
ENSRNOG00000018517.7	ENSRNOT00000093046.1	ENSRNOP00000076071.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.70e-09	37.4	16	83
E3 activity/RING/RING	1.50e-07	32.2	20	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawcee 71
           ee  C+I le+M +P+ +++G+ + +++I +   +gg +cPv+rq++  ++l Pn  + +++++  +e
   Q: 16   EEVTCSICLEPMVEPMSIECGHCFCKECISEVGGNGGGSCPVCRQHFLLRNLRPNRHIANMVENLKQE 83
           7899***************************98888889*****************999998876665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle++ + p++  CgH+f+++C+  +       ++  +CP+Cr
   Q: 20   CSICLEPMVE-PMSIECGHCFCKECISEV-----GGNGGGSCPVCR 59
           ********99.***************999.....7999999****8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSHSTTSKMS LEKMWEEVTC SICLEPMVEP MSIECGHCFC KECISEVGGN GGGSCPVCRQ 60
HFLLRNLRPN RHIANMVENL KQEAQNTKKG TQEVHCMKHG EILHLFCEED GQALCWVCAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGAGGAA ACTGAAAGTG AAATTAGACT GCGGGCTTGC AAAAGTGAAG CTGAAAACAG 60
CCTAGCCAAG TCTGAGGACC CTGGTAAGGT GAGTGAGGAT GGGACCCCTG GCCAGACTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

KEGG

rno:308901

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	69.74	0.00e+00	677.00
IUUC-Bta-013083	Bos taurus	63.58	4.00e-166	577.00
IUUC-Cja-019002	Callithrix jacchus	71.67	0.00e+00	684.00
IUUC-Cfa-020415	Canis familiaris	66.74	0.00e+00	650.00
IUUC-Cpo-021948	Cavia porcellus	64.26	3.00e-179	620.00
IUUC-Csa-023135	Chlorocebus sabaeus	71.89	2.00e-179	621.00
IUUC-Cho-024493	Choloepus hoffmanni	56.52	1.00e-76	279.00
IUUC-Dre-027791	Danio rerio	49.47	3.00e-51	195.00
IUUC-Dno-030061	Dasypus novemcinctus	63.07	1.00e-174	606.00
IUUC-Dor-030451	Dipodomys ordii	69.39	3.00e-82	298.00
IUUC-Ete-033168	Echinops telfairi	61.88	2.00e-151	528.00
IUUC-Eca-033578	Equus caballus	69.23	0.00e+00	649.00
IUUC-Eeu-034749	Erinaceus europaeus	53.72	1.00e-120	426.00
IUUC-Fca-035468	Felis catus	64.36	1.00e-179	622.00
IUUC-Ggo-045190	Gorilla gorilla	71.24	0.00e+00	647.00
IUUC-Hsa-046583	Homo sapiens	70.82	0.00e+00	645.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	71.09	0.00e+00	643.00
IUUC-Laf-053455	Loxodonta africana	67.64	4.00e-174	604.00
IUUC-Mcc-054609	Macaca mulatta	72.10	2.00e-179	622.00
IUUC-Mmr-061369	Microcebus murinus	68.03	5.00e-165	574.00
IUUC-Mmu-063166	Mus musculus	89.85	0.00e+00	832.00
IUUC-Mpu-066889	Mustela putorius furo	68.45	0.00e+00	665.00
IUUC-Mlu-067647	Myotis lucifugus	69.44	8.00e-174	603.00
IUUC-Nle-069567	Nomascus leucogenys	70.39	0.00e+00	641.00
IUUC-Opr-071178	Ochotona princeps	61.80	2.00e-160	559.00
IUUC-Oar-090413	Ovis aries	68.32	6.00e-176	610.00
IUUC-Ptr-091187	Pan troglodytes	70.82	0.00e+00	645.00
IUUC-Pan-092231	Papio anubis	72.10	1.00e-179	622.00
IUUC-Pfo-097458	Poecilia formosa	49.72	1.00e-50	193.00
IUUC-Pab-098079	Pongo abelii	64.84	1.00e-121	429.00
IUUC-Pop-099737	Populus trichocarpa	33.66	1.00e-09	58.90
IUUC-Pca-100639	Procavia capensis	63.69	5.00e-123	434.00
IUUC-Pva-102476	Pteropus vampyrus	68.24	0.00e+00	639.00
IUUC-Sar-113204	Sorex araneus	68.30	5.00e-171	593.00
IUUC-Ssc-116291	Sus scrofa	66.67	1.00e-179	622.00
IUUC-Tsy-118803	Tarsius syrichta	67.07	4.00e-118	418.00
IUUC-Ttr-128914	Tursiops truncatus	66.09	2.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence