iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000004947.15	ENSMUST00000125827.7	ENSMUSP00000115122.1
ENSMUSG00000004947.15	ENSMUST00000005072.9	ENSMUSP00000005072.3
ENSMUSG00000004947.15	ENSMUST00000111145.9	ENSMUSP00000106775.3
ENSMUSG00000004947.15	ENSMUST00000111142.8	ENSMUSP00000106772.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.10e-06	28.3	409	470

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e +                 +   +++ C H+fh+ Cl ++ + + ++ ++ +CP C+
   Q: 409  CIICMEKLavasgysdmtdskalgpMVVGRLTKCSHAFHLLCLLAM-YCNGNKDGSLQCPSCK 470
           ****99998887776665443222211133577**********888.89999**********6 PP

Organism

Mus musculus

Functional Description
(View)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).

Protein Sequence
(Fasta)

MAMAPSSSLP QVYPSHVVVA VWEWQDGLGI WHPYSATVCS FIEQHFVRQR GQHFGLGSLA 60
HSIPLGQADP SLAPYIIDLP SWTQFRQNTG TMRSVRRHLF SQNSAPGQGI VWEWLGDDGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGACATGCG CAGCGCGGTG CTTGGAGGCT GCGACGCCGA GTTTCACTCC GGCTGCCTCC 60
GGCTCGGAGT CGGAGACATA CTCGAGGGTT CTTCCCAGGC CGAGCCGGAG CTGAGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

mmu:74198

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001936	Ailuropoda melanoleuca	82.26	0.00e+00	1012.00
IUUC-Apl-003758	Anas platyrhynchos	55.45	0.00e+00	628.00
IUUC-Aca-004841	Anolis carolinensis	50.55	1.00e-128	452.00
IUUC-Ame-011200	Astyanax mexicanus	65.45	5.00e-111	395.00
IUUC-Cja-018934	Callithrix jacchus	83.76	0.00e+00	1006.00
IUUC-Cfa-020925	Canis familiaris	81.29	0.00e+00	994.00
IUUC-Cpo-021609	Cavia porcellus	84.84	0.00e+00	1034.00
IUUC-Csa-023891	Chlorocebus sabaeus	84.59	0.00e+00	1051.00
IUUC-Dno-029480	Dasypus novemcinctus	82.74	0.00e+00	989.00
IUUC-Dor-031138	Dipodomys ordii	83.06	0.00e+00	995.00
IUUC-Ete-032479	Echinops telfairi	79.30	9.00e-120	424.00
IUUC-Eca-034342	Equus caballus	82.61	0.00e+00	1009.00
IUUC-Eeu-034455	Erinaceus europaeus	69.82	1.00e-99	357.00
IUUC-Fca-036373	Felis catus	83.87	0.00e+00	1009.00
IUUC-Fal-037532	Ficedula albicollis	67.31	1.00e-117	417.00
IUUC-Ggo-045222	Gorilla gorilla	73.68	0.00e+00	901.00
IUUC-Hsa-045716	Homo sapiens	83.79	0.00e+00	1031.00
IUUC-Itr-048253	Ictidomys tridecemlineatus	85.32	0.00e+00	1040.00
IUUC-Lch-050520	Latimeria chalumnae	51.05	6.00e-160	557.00
IUUC-Laf-054290	Loxodonta africana	82.10	0.00e+00	994.00
IUUC-Mcc-054636	Macaca mulatta	84.91	0.00e+00	1025.00
IUUC-Meu-056652	Macropus eugenii	81.74	3.00e-113	402.00
IUUC-Mga-059841	Meleagris gallopavo	59.31	0.00e+00	665.00
IUUC-Mmr-060582	Microcebus murinus	83.87	0.00e+00	1009.00
IUUC-Mdo-062910	Monodelphis domestica	65.20	0.00e+00	779.00
IUUC-Mpu-066817	Mustela putorius furo	76.25	0.00e+00	931.00
IUUC-Mlu-067955	Myotis lucifugus	81.29	0.00e+00	995.00
IUUC-Nle-069055	Nomascus leucogenys	81.51	2.00e-171	596.00
IUUC-Opr-070290	Ochotona princeps	79.55	0.00e+00	982.00
IUUC-Oan-073083	Ornithorhynchus anatinus	53.71	2.00e-146	512.00
IUUC-Ocu-074325	Oryctolagus cuniculus	83.57	0.00e+00	1040.00
IUUC-Ola-087563	Oryzias latipes	43.86	5.00e-123	434.00
IUUC-Oga-088806	Otolemur garnettii	81.96	0.00e+00	1002.00
IUUC-Oar-089906	Ovis aries	77.27	0.00e+00	805.00
IUUC-Ptr-090683	Pan troglodytes	84.75	0.00e+00	1041.00
IUUC-Pan-092356	Papio anubis	84.91	0.00e+00	1025.00
IUUC-Psi-093479	Pelodiscus sinensis	60.69	0.00e+00	718.00
IUUC-Pab-098412	Pongo abelii	84.43	0.00e+00	1046.00
IUUC-Pca-100995	Procavia capensis	68.22	4.00e-87	315.00
IUUC-Pva-103068	Pteropus vampyrus	71.86	0.00e+00	850.00
IUUC-Rno-105159	Rattus norvegicus	97.42	0.00e+00	1159.00
IUUC-Sha-107480	Sarcophilus harrisii	71.29	9.00e-157	546.00
IUUC-Sar-113689	Sorex araneus	71.86	0.00e+00	861.00
IUUC-Ssc-115373	Sus scrofa	90.88	2.00e-154	538.00
IUUC-Tgu-117036	Taeniopygia guttata	60.17	0.00e+00	704.00
IUUC-Tru-118461	Takifugu rubripes	63.16	2.00e-100	360.00
IUUC-Tsy-118930	Tarsius syrichta	84.18	2.00e-129	456.00
IUUC-Tca-121016	Theobroma cacao	40.30	1.00e-05	43.90
IUUC-Tbe-127561	Tupaia belangeri	83.06	0.00e+00	961.00
IUUC-Ttr-128688	Tursiops truncatus	69.29	1.00e-151	530.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence