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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046781
UUCD1 version UUC-HoS-01131
Ensembl Protein ID ENSP00000305926.4
UniProt Accession Q8TE49; Q8IWK5; OTU7A_HUMAN
Genbank Protein ID CAD23047.1; AAH35668.1
Protein Name OTU domain-containing protein 7A; Zinc finger protein Cezanne 2
Genbank Nucleotide ID AJ430383; BC035668
Gene Name OTUD7A; C15orf16; CEZANNE2; OTUD7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169918.9 ENST00000307050.5 ENSP00000305926.4
ENSG00000169918.9 ENST00000560536.5 ENSP00000453622.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDMenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 20622874; 12682062; 21139048
UBD/ZnF/ZnF_A20 ZnF_A20 23827681
Classification
Family E-value Score Start End
DUB/OTU 2.00e-40 140.0 200 374
UBD/ZnF/ZnF_A20 2.00e-15 58.0 885 919
Active Site
Position(s) Description Evidence
207 N/A {ECO:0000250}
210 Nucleophile ECO:0000250}
367 Proton acceptor ECO:0000250}
Domain Profile

   DUB/OTU
   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek....edekefcqklvepe.....ak.g..... 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k    e+e++++ kl+++e     +k g     
   Q: 200  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRTGAEREALKRRWRWQQTQQNKeeewEREWTELLKLASSEprthfSKnGgtggg 291
           6899********************************************************999999************88777444377899 PP
   S: 78   ............eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
                       ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++aLv++
   Q: 292  vdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSALVSM 374
           ********************************************************************************986 PP
   

   UBD/ZnF/ZnF_A20
   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrrr 35
           p++++C++ +C+fYG++et++yCS+Cyreelrrrr
   Q: 885  PVQRRCQReNCAFYGRAETEHYCSYCYREELRRRR 919
           9********************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.
 Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MVSSVLPNPT SAECWAALLH DPMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPHVFNE GRGPKQPERE PQPGHKVERP CLQRQDDIAQ EKRLSRGISH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046781|DUB,OTU;UBD,ZnF_A20|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGGAGGGC GCGCGCCCGG AGGCAGCAGG CGGAGCCGGG AGGCGGGCGT TGTGCGCGGC 60
CGCGGGCGGA GCGGAGGGGC GCGAGGGGCG GAGCGGAGCG CGGGAGGAGG CGGGGGAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046781|DUB,OTU;UBD,ZnF_A20|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20
PROSITE

PS50802--OTU
PS51036--ZF_A20
Pfam

PF02338--OTU
PF01754--zf-A20
SMART

SM00259--ZnF_A20
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
KEGG hsa:161725
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001551 Ailuropoda melanoleuca 97.62 0.00e+00 1028.00
IUUC-Apl-003825 Anas platyrhynchos 71.35 0.00e+00 1118.00
IUUC-Aca-004392 Anolis carolinensis 75.19 0.00e+00 1181.00
IUUC-Ame-011052 Astyanax mexicanus 70.72 0.00e+00 1102.00
IUUC-Bta-013296 Bos taurus 89.52 0.00e+00 1242.00
IUUC-Cja-019141 Callithrix jacchus 95.33 0.00e+00 1088.00
IUUC-Cfa-020447 Canis familiaris 96.33 0.00e+00 1112.00
IUUC-Cpo-022059 Cavia porcellus 95.33 0.00e+00 964.00
IUUC-Csa-023263 Chlorocebus sabaeus 98.67 0.00e+00 1136.00
IUUC-Cho-024611 Choloepus hoffmanni 84.97 2.00e-161 563.00
IUUC-Dre-028617 Danio rerio 68.14 0.00e+00 1091.00
IUUC-Dno-029121 Dasypus novemcinctus 90.70 0.00e+00 1032.00
IUUC-Ete-033068 Echinops telfairi 74.34 0.00e+00 1026.00
IUUC-Eca-034413 Equus caballus 97.13 0.00e+00 1066.00
IUUC-Fca-036487 Felis catus 91.64 0.00e+00 984.00
IUUC-Fal-037145 Ficedula albicollis 77.30 0.00e+00 1164.00
IUUC-Gmo-038786 Gadus morhua 64.03 0.00e+00 989.00
IUUC-Gga-040512 Gallus gallus 77.26 0.00e+00 1213.00
IUUC-Gac-041599 Gasterosteus aculeatus 70.16 0.00e+00 1079.00
IUUC-Ggo-044819 Gorilla gorilla 98.39 0.00e+00 1348.00
IUUC-Itr-047999 Ictidomys tridecemlineatus 89.39 0.00e+00 771.00
IUUC-Lch-050666 Latimeria chalumnae 73.67 0.00e+00 1127.00
IUUC-Loc-052841 Lepisosteus oculatus 71.00 0.00e+00 1134.00
IUUC-Laf-053437 Loxodonta africana 90.79 0.00e+00 1094.00
IUUC-Mcc-055353 Macaca mulatta 96.16 0.00e+00 1442.00
IUUC-Meu-056510 Macropus eugenii 73.29 9.00e-112 398.00
IUUC-Mga-059741 Meleagris gallopavo 75.41 0.00e+00 1174.00
IUUC-Mmr-061437 Microcebus murinus 94.21 0.00e+00 1417.00
IUUC-Mdo-061907 Monodelphis domestica 77.99 0.00e+00 1240.00
IUUC-Mmu-064074 Mus musculus 90.56 0.00e+00 1347.00
IUUC-Mpu-066004 Mustela putorius furo 94.59 0.00e+00 1000.00
IUUC-Nle-069182 Nomascus leucogenys 97.95 0.00e+00 1189.00
IUUC-Opr-070701 Ochotona princeps 88.38 0.00e+00 917.00
IUUC-Ont-072431 Oreochromis niloticus 86.86 0.00e+00 857.00
IUUC-Oan-073235 Ornithorhynchus anatinus 71.70 0.00e+00 1045.00
IUUC-Ocu-073935 Oryctolagus cuniculus 95.90 0.00e+00 1051.00
IUUC-Ola-087026 Oryzias latipes 67.52 0.00e+00 1083.00
IUUC-Oga-088249 Otolemur garnettii 95.73 0.00e+00 1122.00
IUUC-Oar-089476 Ovis aries 89.12 0.00e+00 1342.00
IUUC-Ptr-090548 Pan troglodytes 98.43 0.00e+00 1041.00
IUUC-Pan-092616 Papio anubis 93.45 0.00e+00 1350.00
IUUC-Psi-093126 Pelodiscus sinensis 77.42 0.00e+00 1193.00
IUUC-Pfo-096785 Poecilia formosa 65.56 0.00e+00 1049.00
IUUC-Pab-098336 Pongo abelii 96.48 0.00e+00 1271.00
IUUC-Pca-100206 Procavia capensis 83.67 0.00e+00 806.00
IUUC-Rno-105483 Rattus norvegicus 87.96 0.00e+00 981.00
IUUC-Sha-106617 Sarcophilus harrisii 87.02 0.00e+00 907.00
IUUC-Ssc-115415 Sus scrofa 86.86 0.00e+00 1144.00
IUUC-Tgu-117218 Taeniopygia guttata 85.67 0.00e+00 1038.00
IUUC-Tru-118720 Takifugu rubripes 87.92 0.00e+00 845.00
IUUC-Tni-120795 Tetraodon nigroviridis 80.09 0.00e+00 922.00
IUUC-Xtr-132158 Xenopus tropicalis 69.26 0.00e+00 1168.00
IUUC-Xma-133941 Xiphophorus maculatus 68.95 0.00e+00 1051.00
Created Date 25-Jun-2017

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