iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108282

Ensembl Protein ID

SPAC17A5.13.1:pep

UniProt Accession

O13774; GCH1_SCHPO

Genbank Protein ID

CAB11513.1

Protein Name

GTP cyclohydrolase 1; GTP cyclohydrolase I

Genbank Nucleotide ID

CU329670

Gene Name

fol2; SPAC17A5.13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC17A5.13	SPAC17A5.13.1	SPAC17A5.13.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	56.09	9.00e-70	260.00	IUUC-Hsa-046907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.

Protein Sequence
(Fasta)

MEPGKKDYID SPLRMQPASL SGASTPTIDL DGLSWPCQGT QRRIDTAEEE KVKKISNAIS 60
TILECLGEDP ERQGLLGTPE RYAKAMLYFT KGYEQNLTEV INEAVFQEDH EEMVIVRDID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCTG GAAAAAAGGA TTATATAGAT TCTCCTTTGA GGATGCAACC AGCCTCACTT 60
TCTGGCGCAT CTACACCAAC TATTGATTTA GACGGGCTTT CTTGGCCTTG TAAGTAATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0289--Folate biosynthesis
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom

PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2

Pfam

PF01227--GTP_cyclohydroI

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0046656--P:folic acid biosynthetic process
GO:0009396--P:folic acid-containing compound biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process

KEGG

spo:SPAC17A5.13

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002530	Amborella trichopoda	40.00	2.00e-27	115.00
IUUC-Apl-004135	Anas platyrhynchos	62.92	8.00e-65	237.00
IUUC-Aca-005252	Anolis carolinensis	65.17	2.00e-68	249.00
IUUC-Aly-006454	Arabidopsis lyrata	35.59	4.00e-29	120.00
IUUC-Ath-006744	Arabidopsis thaliana	36.81	3.00e-28	117.00
IUUC-Ago-007744	Ashbya gossypii	63.00	3.00e-78	282.00
IUUC-Acl-008058	Aspergillus clavatus	66.20	4.00e-86	309.00
IUUC-Afl-008668	Aspergillus flavus	67.45	1.00e-86	310.00
IUUC-Afu-008935	Aspergillus fumigatus	65.89	5.00e-86	308.00
IUUC-Ani-009207	Aspergillus nidulans	68.54	9.00e-89	318.00
IUUC-Ang-009686	Aspergillus niger	67.45	7.00e-83	298.00
IUUC-Aor-010202	Aspergillus oryzae	67.45	7.00e-87	311.00
IUUC-Ate-010518	Aspergillus terreus	66.98	3.00e-86	309.00
IUUC-Ame-010958	Astyanax mexicanus	57.55	3.00e-70	256.00
IUUC-Bgr-012060	Blumeria graminis	60.09	6.00e-77	278.00
IUUC-Bta-012416	Bos taurus	62.05	1.00e-71	260.00
IUUC-Bci-013811	Botrytis cinerea	57.02	1.00e-83	300.00
IUUC-Bdi-014794	Brachypodium distachyon	37.20	7.00e-25	106.00
IUUC-Bol-015182	Brassica oleracea	37.17	3.00e-31	127.00
IUUC-Bra-016764	Brassica rapa	36.92	6.00e-30	123.00
IUUC-Cel-018345	Caenorhabditis elegans	65.78	3.00e-73	265.00
IUUC-Cja-019848	Callithrix jacchus	68.38	7.00e-56	206.00
IUUC-Cfa-020630	Canis familiaris	62.05	4.00e-72	262.00
IUUC-Cpo-021420	Cavia porcellus	67.47	4.00e-68	248.00
IUUC-Cre-022618	Chlamydomonas reinhardtii	41.50	1.00e-38	150.00
IUUC-Csa-023403	Chlorocebus sabaeus	60.24	1.00e-55	207.00
IUUC-Cho-024907	Choloepus hoffmanni	62.56	1.00e-72	264.00
IUUC-Cin-025120	Ciona intestinalis	55.61	1.00e-62	230.00
IUUC-Csv-026259	Ciona savignyi	64.44	4.00e-71	258.00
IUUC-Cgl-026508	Colletotrichum gloeosporioides	58.45	3.00e-80	289.00
IUUC-Cne-026810	Cryptococcus neoformans	66.18	2.00e-81	293.00
IUUC-Cme-027139	Cyanidioschyzon merolae	50.53	6.00e-56	208.00
IUUC-Dre-028815	Danio rerio	61.31	3.00e-70	256.00
IUUC-Dno-029017	Dasypus novemcinctus	68.57	1.00e-71	260.00
IUUC-Dor-030417	Dipodomys ordii	69.17	8.00e-55	203.00
IUUC-Dse-031187	Dothistroma septosporum	66.20	2.00e-85	306.00
IUUC-Dme-031615	Drosophila melanogaster	65.12	4.00e-60	222.00
IUUC-Ete-032727	Echinops telfairi	43.87	9.00e-31	124.00
IUUC-Eca-033487	Equus caballus	69.12	2.00e-55	205.00
IUUC-Eeu-034696	Erinaceus europaeus	68.07	5.00e-68	248.00
IUUC-Fca-035975	Felis catus	66.67	3.00e-25	103.00
IUUC-Fal-037439	Ficedula albicollis	68.03	2.00e-60	221.00
IUUC-Fox-037781	Fusarium oxysporum	62.15	3.00e-76	276.00
IUUC-Fso-038377	Fusarium solani	60.28	4.00e-75	272.00
IUUC-Gmo-038945	Gadus morhua	59.28	4.00e-66	241.00
IUUC-Ggr-039834	Gaeumannomyces graminis	61.11	2.00e-81	293.00
IUUC-Gga-040495	Gallus gallus	64.21	8.00e-72	261.00
IUUC-Gac-042306	Gasterosteus aculeatus	58.77	3.00e-70	255.00
IUUC-Gma-043539	Glycine max	35.82	1.00e-31	128.00
IUUC-Ggo-045597	Gorilla gorilla	55.42	9.00e-53	197.00
IUUC-Hsa-046907	Homo sapiens	67.47	8.00e-68	248.00
IUUC-Hvu-047298	Hordeum vulgare	37.97	6.00e-30	123.00
IUUC-Itr-048997	Ictidomys tridecemlineatus	64.32	2.00e-71	259.00
IUUC-Kpa-049319	Komagataella pastoris	63.88	2.00e-84	303.00
IUUC-Lch-049771	Latimeria chalumnae	57.83	1.00e-73	267.00
IUUC-Lpe-050904	Leersia perrieri	37.78	3.00e-28	117.00
IUUC-Loc-052063	Lepisosteus oculatus	63.32	1.00e-72	264.00
IUUC-Lma-053280	Leptosphaeria maculans	52.16	2.00e-63	234.00
IUUC-Laf-054214	Loxodonta africana	62.05	5.00e-72	261.00
IUUC-Mcc-054778	Macaca mulatta	67.47	7.00e-68	248.00
IUUC-Meu-056598	Macropus eugenii	64.18	2.00e-20	90.90
IUUC-Mor-056989	Magnaporthe oryzae	59.43	1.00e-77	280.00
IUUC-Mpo-057591	Magnaporthe poae	62.04	7.00e-82	294.00
IUUC-Mtr-057924	Medicago truncatula	38.54	3.00e-34	137.00
IUUC-Mla-058931	Melampsora laricipopulina	66.84	4.00e-76	276.00
IUUC-Mga-060001	Meleagris gallopavo	69.12	5.00e-56	207.00
IUUC-Mvi-060513	Microbotryum violaceum	61.54	7.00e-81	291.00
IUUC-Mmr-061725	Microcebus murinus	61.81	2.00e-72	263.00
IUUC-Mdo-062715	Monodelphis domestica	57.60	1.00e-71	261.00
IUUC-Mmu-063203	Mus musculus	68.07	2.00e-68	249.00
IUUC-Mac-065392	Musa acuminata	41.21	1.00e-37	147.00
IUUC-Mpu-066174	Mustela putorius furo	62.05	4.00e-72	261.00
IUUC-Mlu-067883	Myotis lucifugus	69.12	5.00e-56	207.00
IUUC-Nfi-068317	Neosartorya fischeri	66.36	2.00e-86	310.00
IUUC-Ncr-068822	Neurospora crassa	62.50	9.00e-80	288.00
IUUC-Nle-069231	Nomascus leucogenys	67.47	8.00e-68	247.00
IUUC-Opr-070417	Ochotona princeps	69.92	6.00e-55	203.00
IUUC-Ont-072168	Oreochromis niloticus	60.80	6.00e-70	254.00
IUUC-Oan-072690	Ornithorhynchus anatinus	68.00	1.00e-25	105.00
IUUC-Ocu-074537	Oryctolagus cuniculus	61.54	3.00e-71	259.00
IUUC-Oba-075333	Oryza barthii	39.23	1.00e-30	125.00
IUUC-Obr-076255	Oryza brachyantha	38.04	8.00e-26	108.00
IUUC-Ogl-077792	Oryza glaberrima	38.89	8.00e-31	125.00
IUUC-Ogu-078354	Oryza glumaepatula	38.89	5.00e-30	123.00
IUUC-Oin-079934	Oryza indica	38.89	5.00e-30	123.00
IUUC-Olo-080643	Oryza longistaminata	35.43	5.00e-25	106.00
IUUC-Ome-081632	Oryza meridionalis	39.55	2.00e-29	121.00
IUUC-Oni-083004	Oryza nivara	38.89	5.00e-30	123.00
IUUC-Opu-083899	Oryza punctata	38.89	1.00e-29	122.00
IUUC-Oru-084386	Oryza rufipogon	38.89	4.00e-30	124.00
IUUC-Osa-085665	Oryza sativa	35.43	4.00e-25	106.00
IUUC-Ola-086577	Oryzias latipes	63.49	8.00e-70	254.00
IUUC-Olu-087867	Ostreococcus lucimarinus	44.68	2.00e-39	152.00
IUUC-Oga-088652	Otolemur garnettii	68.67	4.00e-68	249.00
IUUC-Oar-089965	Ovis aries	62.05	4.00e-72	262.00
IUUC-Ptr-090833	Pan troglodytes	67.47	8.00e-68	248.00
IUUC-Psi-093542	Pelodiscus sinensis	56.25	9.00e-61	224.00
IUUC-Pma-094423	Petromyzon marinus	62.94	1.00e-53	199.00
IUUC-Pno-095091	Phaeosphaeria nodorum	63.00	1.00e-81	293.00
IUUC-Ppa-096013	Physcomitrella patens	40.52	4.00e-27	114.00
IUUC-Pfo-097146	Poecilia formosa	60.80	3.00e-70	256.00
IUUC-Pab-098744	Pongo abelii	67.47	8.00e-68	248.00
IUUC-Pop-099917	Populus trichocarpa	39.16	3.00e-30	124.00
IUUC-Pca-100111	Procavia capensis	61.08	5.00e-72	261.00
IUUC-Ppe-101984	Prunus persica	40.00	7.00e-29	119.00
IUUC-Pva-103078	Pteropus vampyrus	61.54	1.00e-69	253.00
IUUC-Pgr-103438	Puccinia graminis	63.08	6.00e-73	265.00
IUUC-Ptt-103875	Puccinia triticina	63.98	4.00e-71	259.00
IUUC-Pte-104180	Pyrenophora teres	63.00	1.00e-79	287.00
IUUC-Pyt-104552	Pyrenophora triticirepentis	63.00	6.00e-80	288.00
IUUC-Rno-105506	Rattus norvegicus	62.63	4.00e-71	258.00
IUUC-Sce-106375	Saccharomyces cerevisiae	62.45	1.00e-80	290.00
IUUC-Sha-107585	Sarcophilus harrisii	66.18	3.00e-55	204.00
IUUC-Sja-107871	Schizosaccharomyces japonicus	86.40	3.00e-119	418.00
IUUC-Smo-109561	Selaginella moellendorffii	40.11	6.00e-33	132.00
IUUC-Sit-110577	Setaria italica	34.97	4.00e-26	110.00
IUUC-Sly-111719	Solanum lycopersicum	43.14	3.00e-31	127.00
IUUC-Stu-112752	Solanum tuberosum	43.23	2.00e-32	131.00
IUUC-Sar-113701	Sorex araneus	64.67	7.00e-71	258.00
IUUC-Sbi-114308	Sorghum bicolor	36.36	2.00e-29	121.00
IUUC-Sre-115125	Sporisorium reilianum	57.69	2.00e-79	287.00
IUUC-Tgu-117039	Taeniopygia guttata	69.12	6.00e-56	207.00
IUUC-Tru-117939	Takifugu rubripes	57.87	3.00e-69	253.00
IUUC-Tsy-118852	Tarsius syrichta	58.65	9.00e-43	163.00
IUUC-Tni-120356	Tetraodon nigroviridis	60.30	3.00e-69	252.00
IUUC-Tca-121422	Theobroma cacao	36.18	1.00e-31	129.00
IUUC-Tre-122035	Trichoderma reesei	61.01	8.00e-82	294.00
IUUC-Tvi-122649	Trichoderma virens	62.21	7.00e-83	298.00
IUUC-Tae-124146	Triticum aestivum	36.41	2.00e-30	124.00
IUUC-Tme-127015	Tuber melanosporum	65.91	8.00e-85	304.00
IUUC-Tbe-128024	Tupaia belangeri	58.65	7.00e-43	163.00
IUUC-Ttr-128474	Tursiops truncatus	57.66	4.00e-72	262.00
IUUC-Uma-129655	Ustilago maydis	61.29	1.00e-80	291.00
IUUC-Vda-129970	Verticillium dahliae	61.32	2.00e-80	290.00
IUUC-Vpa-130564	Vicugna pacos	69.92	4.00e-55	204.00
IUUC-Vvi-131597	Vitis vinifera	38.60	2.00e-32	131.00
IUUC-Xtr-132201	Xenopus tropicalis	60.38	5.00e-73	265.00
IUUC-Xma-133679	Xiphophorus maculatus	56.70	1.00e-70	256.00
IUUC-Yli-134489	Yarrowia lipolytica	65.64	3.00e-85	305.00
IUUC-Zma-135058	Zea mays	35.38	2.00e-28	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence