iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21273419

Classification

Family	E-value	Score	Start	End
DUB/USP	4.30e-97	325.6	28	405

Active Site

Position(s)	Description	Evidence
36	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
342	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqEfla 97
           Gl N+gNtCY+NSv+Q+L++++++re +l+ +k++l+++    +k +l+++l++lf+++   k++ + ++p++++++lkke+e f++y+qqDa+Ef++
   Q: 28   GLVNFGNTCYCNSVIQALFFCRPFREKVLN-YKQTLKKS--GASKDNLVTCLADLFHSIAsqKRRVGTIAPKRFITKLKKENELFDNYMQQDAHEFFN 122
           9*****************************.*****998..789***************976777789****************************** PP
   S: 98   flldqleeelkkeknkpkeeeeeedkselsde................................aeekkkkknkslisdlFqgqlksqikclecdnvs 163
           +l+++++e+l   ++k  e+e+ +++ +l++                                 +e  +k+ ++++i+++Fqg l+++++cl+c++vs
   Q: 123  YLINTISETL--IQEKIAEREKASRHGTLKKGnvtvnlapataglprsdekgtsernggitvegNEFLNKSDTTTWIHEIFQGILTNETRCLSCETVS 218
           **********..455555555555544444448899**************************999999999999************************ PP
   S: 164  sreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           s++e+fldls++v++++     s+++cL+ f+++e+l+g++ky+ce+c +kqea+k++++kk P+ L lhLkRf+f e  ++++k++ +v fpleL l
   Q: 219  SKDEDFLDLSIDVEQNT-----SISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELRL 311
           *****************.....9**********************************************************************77777 PP
   S: 262  spfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.....................staYvlfYkr 337
             f++s++ +   ++ Y+L+a vvH G +++ GHY+++vk++   Wl fdD+ V++++ ++++e++g                     ++aY+lfY+ 
   Q: 312  --FNVSDDAEY-GDRMYDLVATVVHCGaTPNRGHYITLVKSN-SFWLVFDDDIVEKLEVSSMEEFSGmstdaniqmppgnqsapqknsESAYILFYQA 405
           ..555544443.48***************************5.55*******************999*****************************97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity.

Protein Sequence
(Fasta)

MGATGSSQLE KEISTTESVN NANEHYYGLV NFGNTCYCNS VIQALFFCRP FREKVLNYKQ 60
TLKKSGASKD NLVTCLADLF HSIASQKRRV GTIAPKRFIT KLKKENELFD NYMQQDAHEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTCTCCCC TTCTTTGCCC CCTCTTTATC GTTCTATTTC ACGTTGTTCC GCTAGTAACC 60
GTTATTCTGA AAATCTGTTT TTTTCTTGTA GCTGTTGGCA CACTCAATGG GAGCTACTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0519--Myristate
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0043025--C:neuronal cell body
GO:0043204--C:perikaryon
GO:0035255--F:ionotropic glutamate receptor binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0010628--P:positive regulation of gene expression
GO:0090326--P:positive regulation of locomotion involved in locomotory behavior
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000311--P:regulation of AMPA receptor activity

KEGG

cel:CELE_R10E11.3

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	47.65	4.00e-106	376.00
IUUC-Aml-002353	Ailuropoda melanoleuca	61.67	1.00e-139	488.00
IUUC-Atr-002650	Amborella trichopoda	50.62	2.00e-110	390.00
IUUC-Apl-003380	Anas platyrhynchos	61.23	1.00e-139	488.00
IUUC-Aca-005031	Anolis carolinensis	62.41	7.00e-145	505.00
IUUC-Aly-005830	Arabidopsis lyrata	48.89	1.00e-109	387.00
IUUC-Ath-007280	Arabidopsis thaliana	48.89	2.00e-109	387.00
IUUC-Ago-007871	Ashbya gossypii	34.39	2.00e-29	122.00
IUUC-Acl-008239	Aspergillus clavatus	40.18	2.00e-68	252.00
IUUC-Afl-008602	Aspergillus flavus	41.72	1.00e-69	256.00
IUUC-Afu-008816	Aspergillus fumigatus	41.37	3.00e-69	255.00
IUUC-Ani-009137	Aspergillus nidulans	49.07	2.00e-59	222.00
IUUC-Ang-009703	Aspergillus niger	40.77	8.00e-70	257.00
IUUC-Aor-009901	Aspergillus oryzae	41.72	8.00e-70	256.00
IUUC-Ate-010431	Aspergillus terreus	40.48	3.00e-68	251.00
IUUC-Ame-011015	Astyanax mexicanus	60.93	3.00e-143	499.00
IUUC-Bgr-012071	Blumeria graminis	39.94	4.00e-70	258.00
IUUC-Bta-013023	Bos taurus	61.48	8.00e-140	488.00
IUUC-Bci-013837	Botrytis cinerea	37.87	4.00e-67	248.00
IUUC-Bdi-014008	Brachypodium distachyon	48.89	5.00e-109	386.00
IUUC-Bol-015409	Brassica oleracea	50.12	1.00e-109	389.00
IUUC-Bra-016956	Brassica rapa	50.12	6.00e-110	389.00
IUUC-Cja-018956	Callithrix jacchus	61.33	2.00e-139	487.00
IUUC-Cfa-020534	Canis familiaris	61.92	9.00e-144	501.00
IUUC-Cpo-022443	Cavia porcellus	61.18	1.00e-139	488.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	45.68	2.00e-89	321.00
IUUC-Csa-023841	Chlorocebus sabaeus	61.67	1.00e-139	488.00
IUUC-Cho-024902	Choloepus hoffmanni	50.25	8.00e-107	378.00
IUUC-Cin-025659	Ciona intestinalis	53.65	5.00e-125	439.00
IUUC-Csv-025828	Ciona savignyi	51.43	3.00e-122	430.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	40.18	2.00e-70	259.00
IUUC-Cne-026900	Cryptococcus neoformans	37.27	3.00e-53	202.00
IUUC-Dre-028230	Danio rerio	62.16	2.00e-142	496.00
IUUC-Dno-029209	Dasypus novemcinctus	61.48	2.00e-139	486.00
IUUC-Dor-030972	Dipodomys ordii	59.67	6.00e-101	359.00
IUUC-Dse-031470	Dothistroma septosporum	40.86	4.00e-72	264.00
IUUC-Dme-032038	Drosophila melanogaster	64.65	4.00e-85	306.00
IUUC-Ete-033125	Echinops telfairi	50.00	2.00e-84	304.00
IUUC-Eca-033721	Equus caballus	61.48	3.00e-139	486.00
IUUC-Eeu-034916	Erinaceus europaeus	63.06	2.00e-114	403.00
IUUC-Fca-036299	Felis catus	61.48	2.00e-139	487.00
IUUC-Fal-036833	Ficedula albicollis	61.58	8.00e-142	495.00
IUUC-Fox-037682	Fusarium oxysporum	39.34	4.00e-67	248.00
IUUC-Fso-038299	Fusarium solani	33.71	8.00e-67	246.00
IUUC-Gmo-038763	Gadus morhua	59.71	2.00e-141	494.00
IUUC-Ggr-039806	Gaeumannomyces graminis	37.68	4.00e-69	254.00
IUUC-Gga-041157	Gallus gallus	61.43	8.00e-140	488.00
IUUC-Gac-041967	Gasterosteus aculeatus	60.69	3.00e-142	496.00
IUUC-Gma-043448	Glycine max	49.63	2.00e-109	387.00
IUUC-Ggo-044659	Gorilla gorilla	61.48	2.00e-139	486.00
IUUC-Hsa-046156	Homo sapiens	61.67	1.00e-139	488.00
IUUC-Hvu-047692	Hordeum vulgare	48.15	1.00e-104	371.00
IUUC-Itr-048157	Ictidomys tridecemlineatus	61.67	1.00e-139	488.00
IUUC-Kpa-049250	Komagataella pastoris	35.61	4.00e-61	227.00
IUUC-Lch-049969	Latimeria chalumnae	70.89	1.00e-90	325.00
IUUC-Lpe-051368	Leersia perrieri	48.15	4.00e-106	376.00
IUUC-Loc-052559	Lepisosteus oculatus	61.43	2.00e-142	497.00
IUUC-Lma-053300	Leptosphaeria maculans	40.18	2.00e-69	255.00
IUUC-Laf-054085	Loxodonta africana	61.67	1.00e-139	488.00
IUUC-Mcc-055566	Macaca mulatta	61.33	1.00e-139	488.00
IUUC-Mor-057072	Magnaporthe oryzae	39.66	1.00e-71	263.00
IUUC-Mpo-057424	Magnaporthe poae	38.24	9.00e-69	253.00
IUUC-Mtr-058768	Medicago truncatula	50.37	8.00e-110	389.00
IUUC-Mla-059142	Melampsora laricipopulina	44.94	5.00e-84	305.00
IUUC-Mga-059575	Meleagris gallopavo	60.93	2.00e-139	487.00
IUUC-Mvi-060357	Microbotryum violaceum	46.15	8.00e-72	264.00
IUUC-Mmr-060751	Microcebus murinus	61.92	9.00e-144	501.00
IUUC-Mdo-062579	Monodelphis domestica	61.43	3.00e-139	486.00
IUUC-Mmu-063611	Mus musculus	61.67	1.00e-139	488.00
IUUC-Mac-065541	Musa acuminata	48.15	9.00e-107	378.00
IUUC-Mpu-066038	Mustela putorius furo	61.48	4.00e-139	486.00
IUUC-Mlu-068183	Myotis lucifugus	61.48	1.00e-139	488.00
IUUC-Nfi-068611	Neosartorya fischeri	41.37	3.00e-69	254.00
IUUC-Ncr-068699	Neurospora crassa	40.30	4.00e-68	251.00
IUUC-Nle-069330	Nomascus leucogenys	61.67	1.00e-139	488.00
IUUC-Opr-070980	Ochotona princeps	61.48	1.00e-139	487.00
IUUC-Ont-072134	Oreochromis niloticus	61.67	2.00e-143	500.00
IUUC-Oan-073372	Ornithorhynchus anatinus	60.99	4.00e-142	496.00
IUUC-Ocu-074923	Oryctolagus cuniculus	61.48	2.00e-139	487.00
IUUC-Oba-075220	Oryza barthii	48.89	2.00e-106	377.00
IUUC-Obr-076088	Oryza brachyantha	48.15	1.00e-104	371.00
IUUC-Ogl-077216	Oryza glaberrima	48.89	2.00e-106	377.00
IUUC-Ogu-078836	Oryza glumaepatula	48.89	2.00e-106	377.00
IUUC-Oin-079522	Oryza indica	48.89	2.00e-106	377.00
IUUC-Olo-080882	Oryza longistaminata	48.89	2.00e-106	377.00
IUUC-Ome-081549	Oryza meridionalis	48.89	2.00e-106	377.00
IUUC-Oni-082982	Oryza nivara	48.89	2.00e-106	377.00
IUUC-Opu-083532	Oryza punctata	48.64	5.00e-107	379.00
IUUC-Oru-084568	Oryza rufipogon	48.89	2.00e-106	377.00
IUUC-Osa-085299	Oryza sativa	48.89	2.00e-106	377.00
IUUC-Ola-086546	Oryzias latipes	61.48	1.00e-142	498.00
IUUC-Olu-087809	Ostreococcus lucimarinus	38.96	8.00e-73	265.00
IUUC-Oga-088073	Otolemur garnettii	61.48	3.00e-139	486.00
IUUC-Oar-089248	Ovis aries	61.48	2.00e-139	487.00
IUUC-Ptr-090814	Pan troglodytes	61.67	1.00e-139	488.00
IUUC-Pan-091753	Papio anubis	61.67	1.00e-139	488.00
IUUC-Psi-094012	Pelodiscus sinensis	61.23	2.00e-139	486.00
IUUC-Pma-094388	Petromyzon marinus	62.35	2.00e-142	497.00
IUUC-Pno-095044	Phaeosphaeria nodorum	40.23	3.00e-69	254.00
IUUC-Ppa-095415	Physcomitrella patens	48.89	1.00e-108	384.00
IUUC-Pfo-097369	Poecilia formosa	61.67	3.00e-143	499.00
IUUC-Pab-098594	Pongo abelii	61.67	1.00e-139	487.00
IUUC-Pop-099798	Populus trichocarpa	49.38	6.00e-110	389.00
IUUC-Pca-100835	Procavia capensis	56.38	2.00e-117	414.00
IUUC-Ppe-101474	Prunus persica	49.14	1.00e-109	388.00
IUUC-Pva-102892	Pteropus vampyrus	61.18	2.00e-139	487.00
IUUC-Pgr-103306	Puccinia graminis	45.54	6.00e-85	308.00
IUUC-Pte-104356	Pyrenophora teres	40.35	3.00e-71	262.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	40.35	2.00e-71	262.00
IUUC-Rno-104909	Rattus norvegicus	61.67	8.00e-140	488.00
IUUC-Sce-106367	Saccharomyces cerevisiae	33.52	6.00e-51	194.00
IUUC-Sha-107400	Sarcophilus harrisii	61.23	6.00e-139	485.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	36.94	8.00e-61	226.00
IUUC-Spo-108095	Schizosaccharomyces pombe	38.39	5.00e-68	250.00
IUUC-Smo-109064	Selaginella moellendorffii	49.14	1.00e-106	378.00
IUUC-Sit-110819	Setaria italica	49.51	6.00e-110	389.00
IUUC-Sly-111210	Solanum lycopersicum	48.77	3.00e-108	383.00
IUUC-Stu-112398	Solanum tuberosum	47.42	6.00e-106	375.00
IUUC-Sar-113216	Sorex araneus	61.08	1.00e-140	491.00
IUUC-Sbi-114724	Sorghum bicolor	48.77	1.00e-108	385.00
IUUC-Sre-115197	Sporisorium reilianum	45.43	5.00e-77	281.00
IUUC-Ssc-115550	Sus scrofa	61.48	2.00e-139	487.00
IUUC-Tgu-116800	Taeniopygia guttata	61.43	1.00e-139	488.00
IUUC-Tru-118212	Takifugu rubripes	61.43	1.00e-143	501.00
IUUC-Tsy-119520	Tarsius syrichta	52.67	1.00e-83	301.00
IUUC-Tni-120071	Tetraodon nigroviridis	61.92	1.00e-143	501.00
IUUC-Tca-121329	Theobroma cacao	49.14	2.00e-109	387.00
IUUC-Tre-122226	Trichoderma reesei	39.76	1.00e-68	253.00
IUUC-Tvi-122330	Trichoderma virens	38.92	3.00e-68	251.00
IUUC-Tae-124807	Triticum aestivum	48.40	7.00e-107	379.00
IUUC-Tur-126563	Triticum urartu	47.90	1.00e-106	378.00
IUUC-Tme-126890	Tuber melanosporum	42.40	7.00e-85	306.00
IUUC-Tbe-127783	Tupaia belangeri	61.29	7.00e-141	491.00
IUUC-Ttr-129083	Tursiops truncatus	61.43	3.00e-143	499.00
IUUC-Uma-129409	Ustilago maydis	44.82	2.00e-76	279.00
IUUC-Vda-129736	Verticillium dahliae	36.42	3.00e-55	208.00
IUUC-Vpa-130590	Vicugna pacos	58.02	3.00e-127	446.00
IUUC-Vvi-131371	Vitis vinifera	49.39	6.00e-111	392.00
IUUC-Xtr-132082	Xenopus tropicalis	61.67	2.00e-142	496.00
IUUC-Xma-133111	Xiphophorus maculatus	61.67	2.00e-143	500.00
IUUC-Yli-134632	Yarrowia lipolytica	38.18	1.00e-69	256.00
IUUC-Zma-134951	Zea mays	48.77	5.00e-109	386.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence