iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021239

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAEX03003735

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018523.3	ENSCAFT00000029408.2	ENSCAFP00000027342.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.40e-93	312.8	123	466

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 123  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 207
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 208  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 280
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 281  STPFWPlspgsegsvvngeshvagttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 367
           *87777************************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + e+vl  
   Q: 368  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIEDVLD- 455
           *******************5555555555554445555**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 456  --SEGYLLFYHKQ 466
           ..********985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

ERKAKSCVCH VCGVHLNRLH SCLHCVFFGC FTKKHIHEHA KSKRHNLAIE LMYGGIYCFL 60
CQDYIYDKDI EIIAKEEQRK AWKMQGVGEK FSTWEPTKRE LELLKHNPKR RKITSNCTIG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACGTAAGG TTTTTAATTC TCTTCACTCC CTTTCAGGCC AAGTCATGCG TCTGTCACGT 60
TTGTGGTGTT CACCTGAACA GGCTCCACTC CTGCCTGCAC TGTGTCTTCT TTGGCTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	38.12	2.00e-65	243.00
IUUC-Aml-001343	Ailuropoda melanoleuca	98.30	0.00e+00	974.00
IUUC-Atr-002653	Amborella trichopoda	39.18	6.00e-96	344.00
IUUC-Apl-003433	Anas platyrhynchos	92.36	0.00e+00	947.00
IUUC-Aca-005347	Anolis carolinensis	89.22	0.00e+00	938.00
IUUC-Ago-007811	Ashbya gossypii	31.57	7.00e-54	204.00
IUUC-Acl-008124	Aspergillus clavatus	31.84	1.00e-58	220.00
IUUC-Afl-008464	Aspergillus flavus	32.77	1.00e-54	206.00
IUUC-Afu-008912	Aspergillus fumigatus	31.16	1.00e-56	213.00
IUUC-Ani-009168	Aspergillus nidulans	32.56	1.00e-58	220.00
IUUC-Ang-009694	Aspergillus niger	31.88	1.00e-56	214.00
IUUC-Aor-010035	Aspergillus oryzae	34.83	3.00e-38	151.00
IUUC-Ate-010382	Aspergillus terreus	32.05	2.00e-52	199.00
IUUC-Ame-011253	Astyanax mexicanus	85.35	0.00e+00	834.00
IUUC-Bgr-012150	Blumeria graminis	31.20	5.00e-49	188.00
IUUC-Bta-013303	Bos taurus	98.94	0.00e+00	979.00
IUUC-Bci-013604	Botrytis cinerea	32.63	2.00e-57	216.00
IUUC-Bdi-014171	Brachypodium distachyon	35.36	1.00e-76	281.00
IUUC-Cja-019283	Callithrix jacchus	98.58	0.00e+00	883.00
IUUC-Cpo-022354	Cavia porcellus	97.24	0.00e+00	966.00
IUUC-Csa-023145	Chlorocebus sabaeus	98.09	0.00e+00	976.00
IUUC-Cho-024938	Choloepus hoffmanni	96.55	8.00e-66	244.00
IUUC-Cin-025109	Ciona intestinalis	57.56	3.00e-122	431.00
IUUC-Csv-026214	Ciona savignyi	57.26	2.00e-169	589.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.10	1.00e-55	210.00
IUUC-Cne-027085	Cryptococcus neoformans	32.89	8.00e-63	234.00
IUUC-Dre-027433	Danio rerio	93.16	0.00e+00	926.00
IUUC-Dno-030095	Dasypus novemcinctus	97.01	0.00e+00	965.00
IUUC-Dor-030481	Dipodomys ordii	96.53	1.00e-99	357.00
IUUC-Dse-031415	Dothistroma septosporum	32.58	4.00e-62	232.00
IUUC-Dme-032074	Drosophila melanogaster	53.55	7.00e-136	477.00
IUUC-Ete-033175	Echinops telfairi	76.90	0.00e+00	631.00
IUUC-Eca-033736	Equus caballus	98.72	0.00e+00	973.00
IUUC-Eeu-034814	Erinaceus europaeus	100.00	1.00e-123	436.00
IUUC-Fca-035861	Felis catus	99.36	0.00e+00	979.00
IUUC-Fal-037645	Ficedula albicollis	92.65	0.00e+00	932.00
IUUC-Fox-038046	Fusarium oxysporum	31.40	2.00e-55	210.00
IUUC-Fso-038321	Fusarium solani	33.26	2.00e-55	209.00
IUUC-Gmo-038474	Gadus morhua	93.92	3.00e-171	595.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.31	5.00e-57	215.00
IUUC-Gga-040624	Gallus gallus	92.39	0.00e+00	949.00
IUUC-Gac-042197	Gasterosteus aculeatus	86.69	0.00e+00	863.00
IUUC-Gma-042897	Glycine max	33.71	1.00e-81	297.00
IUUC-Ggo-044409	Gorilla gorilla	98.09	0.00e+00	978.00
IUUC-Hsa-046521	Homo sapiens	98.09	0.00e+00	977.00
IUUC-Hvu-047739	Hordeum vulgare	38.67	7.00e-70	257.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	97.45	0.00e+00	969.00
IUUC-Kpa-049135	Komagataella pastoris	35.28	7.00e-69	254.00
IUUC-Lch-050537	Latimeria chalumnae	94.27	0.00e+00	951.00
IUUC-Lpe-050969	Leersia perrieri	38.13	3.00e-73	268.00
IUUC-Loc-052765	Lepisosteus oculatus	83.00	0.00e+00	834.00
IUUC-Lma-053105	Leptosphaeria maculans	34.60	5.00e-66	244.00
IUUC-Laf-053571	Loxodonta africana	97.65	0.00e+00	967.00
IUUC-Mcc-055166	Macaca mulatta	98.09	0.00e+00	976.00
IUUC-Mor-057103	Magnaporthe oryzae	31.63	9.00e-57	214.00
IUUC-Mpo-057621	Magnaporthe poae	32.53	2.00e-56	213.00
IUUC-Mtr-057769	Medicago truncatula	35.02	1.00e-82	300.00
IUUC-Mla-059185	Melampsora laricipopulina	29.95	1.00e-42	167.00
IUUC-Mga-059709	Meleagris gallopavo	92.36	0.00e+00	947.00
IUUC-Mvi-060530	Microbotryum violaceum	34.25	2.00e-58	219.00
IUUC-Mmr-060988	Microcebus murinus	98.09	0.00e+00	974.00
IUUC-Mdo-063065	Monodelphis domestica	95.33	0.00e+00	960.00
IUUC-Mmu-063829	Mus musculus	98.09	0.00e+00	974.00
IUUC-Mac-065419	Musa acuminata	40.11	4.00e-72	265.00
IUUC-Mpu-066687	Mustela putorius furo	98.73	0.00e+00	976.00
IUUC-Nfi-068423	Neosartorya fischeri	31.40	1.00e-56	214.00
IUUC-Ncr-068809	Neurospora crassa	31.25	2.00e-58	220.00
IUUC-Nle-069261	Nomascus leucogenys	93.84	0.00e+00	921.00
IUUC-Opr-070469	Ochotona princeps	79.91	0.00e+00	689.00
IUUC-Ont-071961	Oreochromis niloticus	90.45	0.00e+00	902.00
IUUC-Oan-073565	Ornithorhynchus anatinus	85.96	0.00e+00	917.00
IUUC-Ocu-074435	Oryctolagus cuniculus	98.25	0.00e+00	947.00
IUUC-Oba-075688	Oryza barthii	35.99	5.00e-76	278.00
IUUC-Obr-076652	Oryza brachyantha	41.69	6.00e-75	274.00
IUUC-Ogl-077910	Oryza glaberrima	35.89	1.00e-78	287.00
IUUC-Ogu-078479	Oryza glumaepatula	35.89	1.00e-78	287.00
IUUC-Oin-079697	Oryza indica	39.66	4.00e-76	278.00
IUUC-Olo-080811	Oryza longistaminata	41.38	4.00e-53	201.00
IUUC-Ome-081706	Oryza meridionalis	35.89	3.00e-78	286.00
IUUC-Oni-083070	Oryza nivara	35.48	2.00e-78	286.00
IUUC-Opu-083605	Oryza punctata	40.16	8.00e-68	250.00
IUUC-Oru-084522	Oryza rufipogon	35.89	1.00e-78	287.00
IUUC-Osa-085351	Oryza sativa	39.36	1.00e-76	280.00
IUUC-Ola-086743	Oryzias latipes	88.31	0.00e+00	757.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.81	2.00e-50	192.00
IUUC-Oga-089131	Otolemur garnettii	94.25	0.00e+00	958.00
IUUC-Oar-089319	Ovis aries	99.15	0.00e+00	975.00
IUUC-Ptr-090783	Pan troglodytes	97.87	0.00e+00	973.00
IUUC-Pan-092927	Papio anubis	97.88	0.00e+00	975.00
IUUC-Psi-093670	Pelodiscus sinensis	92.55	0.00e+00	947.00
IUUC-Pma-094323	Petromyzon marinus	71.55	0.00e+00	721.00
IUUC-Pno-095141	Phaeosphaeria nodorum	32.95	7.00e-57	214.00
IUUC-Pfo-096462	Poecilia formosa	92.16	0.00e+00	923.00
IUUC-Pab-097612	Pongo abelii	98.30	0.00e+00	978.00
IUUC-Pte-104340	Pyrenophora teres	33.71	1.00e-59	224.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	35.28	3.00e-67	249.00
IUUC-Rno-105247	Rattus norvegicus	98.09	0.00e+00	975.00
IUUC-Sce-106247	Saccharomyces cerevisiae	32.25	8.00e-53	201.00
IUUC-Sha-107538	Sarcophilus harrisii	95.85	1.00e-124	438.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.69	1.00e-66	246.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.14	2.00e-54	206.00
IUUC-Sit-109716	Setaria italica	35.63	1.00e-79	290.00
IUUC-Sar-113341	Sorex araneus	87.23	0.00e+00	760.00
IUUC-Sbi-114205	Sorghum bicolor	35.14	2.00e-80	293.00
IUUC-Tgu-116938	Taeniopygia guttata	95.31	0.00e+00	956.00
IUUC-Tru-117622	Takifugu rubripes	89.30	0.00e+00	917.00
IUUC-Tsy-119431	Tarsius syrichta	86.11	0.00e+00	817.00
IUUC-Tni-120661	Tetraodon nigroviridis	92.14	0.00e+00	929.00
IUUC-Tre-122139	Trichoderma reesei	32.18	9.00e-55	207.00
IUUC-Tvi-122599	Trichoderma virens	31.61	8.00e-56	211.00
IUUC-Tae-125608	Triticum aestivum	35.56	3.00e-86	312.00
IUUC-Tme-127115	Tuber melanosporum	38.48	2.00e-81	296.00
IUUC-Ttr-129018	Tursiops truncatus	95.38	0.00e+00	821.00
IUUC-Uma-129455	Ustilago maydis	31.74	3.00e-33	137.00
IUUC-Vda-129829	Verticillium dahliae	32.89	1.00e-35	143.00
IUUC-Xtr-132444	Xenopus tropicalis	91.15	0.00e+00	940.00
IUUC-Xma-133514	Xiphophorus maculatus	92.78	0.00e+00	933.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	3.00e-48	186.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence