iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028107

UUCD1 version

UUC-DaR-00579

Ensembl Protein ID

ENSDARP00000082852.6

UniProt Accession

Q1LVZ2; A2RV25; MARH2_DANRE

Genbank Protein ID

CAK04341.1; AAI33147.1

Protein Name

E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING-type E3 ubiquitin transferase MARCH2

Genbank Nucleotide ID

BX649327; BC133146

Gene Name

march2; si:ch211-197g15.3; zgc:158704

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000061738.6	ENSDART00000088419.6	ENSDARP00000082852.6

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	77.11	8.00e-103	370.00	IUUC-Hsa-046263

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTTGECCHLP GSLCDCTGNA ALSKTVEEAD NRRAQYVTQV TAKDGRLLST VIKALGTQSD 60
RPICRICHEG QDVCNSEGLL SPCDCTGTLG TVHKSCLEKW LSSSNTSYCE LCHTEFTIER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACTGCGTC GGTAGGAGGC CGAGCCGAGT CGTTTGCTGA ACGGATCAAA CCCAAAACAA 60
GCGTTGTAAT TTTACCTTAT CACCAATCAA CAAGCGCCAC CATTAAACGG ATTTCACCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0030097--P:hemopoiesis
GO:0016567--P:protein ubiquitination

KEGG

dre:555611

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002189	Ailuropoda melanoleuca	78.31	7.00e-109	386.00
IUUC-Apl-004200	Anas platyrhynchos	87.19	1.00e-124	438.00
IUUC-Aca-005012	Anolis carolinensis	67.05	5.00e-99	353.00
IUUC-Ame-010786	Astyanax mexicanus	97.19	2.00e-130	458.00
IUUC-Bta-012678	Bos taurus	74.70	5.00e-106	377.00
IUUC-Bra-016852	Brassica rapa	33.03	1.00e-08	53.90
IUUC-Cel-018164	Caenorhabditis elegans	33.59	7.00e-16	78.60
IUUC-Cja-019689	Callithrix jacchus	69.14	5.00e-100	357.00
IUUC-Cfa-020820	Canis familiaris	78.31	1.00e-113	402.00
IUUC-Cpo-021511	Cavia porcellus	76.71	2.00e-109	388.00
IUUC-Csa-024010	Chlorocebus sabaeus	68.75	9.00e-100	356.00
IUUC-Cho-024645	Choloepus hoffmanni	73.82	9.00e-83	299.00
IUUC-Dno-029379	Dasypus novemcinctus	77.51	1.00e-103	369.00
IUUC-Dor-031059	Dipodomys ordii	77.91	2.00e-111	395.00
IUUC-Ete-032571	Echinops telfairi	68.75	3.00e-99	354.00
IUUC-Eca-034013	Equus caballus	76.71	2.00e-104	372.00
IUUC-Eeu-035139	Erinaceus europaeus	71.65	1.00e-48	184.00
IUUC-Fca-035894	Felis catus	78.31	1.00e-112	398.00
IUUC-Fal-037434	Ficedula albicollis	82.33	3.00e-111	394.00
IUUC-Gmo-039276	Gadus morhua	84.40	2.00e-119	421.00
IUUC-Gga-041224	Gallus gallus	85.14	4.00e-122	430.00
IUUC-Gac-042104	Gasterosteus aculeatus	77.73	2.00e-112	398.00
IUUC-Ggo-044825	Gorilla gorilla	68.75	2.00e-99	355.00
IUUC-Hsa-046263	Homo sapiens	77.11	3.00e-110	391.00
IUUC-Itr-048963	Ictidomys tridecemlineatus	77.91	9.00e-112	395.00
IUUC-Lch-050103	Latimeria chalumnae	89.96	7.00e-124	436.00
IUUC-Loc-052480	Lepisosteus oculatus	86.35	3.00e-125	440.00
IUUC-Laf-054410	Loxodonta africana	77.11	2.00e-111	395.00
IUUC-Mcc-054712	Macaca mulatta	77.11	1.00e-110	392.00
IUUC-Mtr-057809	Medicago truncatula	35.78	6.00e-11	61.20
IUUC-Mga-060053	Meleagris gallopavo	85.54	1.00e-126	445.00
IUUC-Mmr-061764	Microcebus murinus	73.80	2.00e-80	291.00
IUUC-Mdo-062010	Monodelphis domestica	84.34	2.00e-123	434.00
IUUC-Mmu-064040	Mus musculus	78.10	1.00e-109	389.00
IUUC-Mpu-066205	Mustela putorius furo	78.71	5.00e-113	400.00
IUUC-Mlu-067013	Myotis lucifugus	74.21	3.00e-105	374.00
IUUC-Nle-069945	Nomascus leucogenys	68.75	9.00e-100	356.00
IUUC-Opr-070431	Ochotona princeps	68.75	7.00e-99	353.00
IUUC-Ont-071768	Oreochromis niloticus	82.47	3.00e-119	421.00
IUUC-Oan-073269	Ornithorhynchus anatinus	65.74	6.00e-91	326.00
IUUC-Ocu-074212	Oryctolagus cuniculus	77.51	2.00e-111	395.00
IUUC-Ola-087137	Oryzias latipes	74.90	2.00e-100	358.00
IUUC-Oga-088712	Otolemur garnettii	77.51	2.00e-111	394.00
IUUC-Oar-090175	Ovis aries	74.30	1.00e-103	369.00
IUUC-Ptr-090839	Pan troglodytes	68.75	2.00e-99	355.00
IUUC-Pan-092276	Papio anubis	77.11	6.00e-111	393.00
IUUC-Psi-094007	Pelodiscus sinensis	87.55	7.00e-129	452.00
IUUC-Pma-094464	Petromyzon marinus	60.31	9.00e-66	242.00
IUUC-Pfo-097509	Poecilia formosa	84.14	2.00e-110	391.00
IUUC-Pab-098050	Pongo abelii	68.75	9.00e-100	356.00
IUUC-Pca-100424	Procavia capensis	76.31	6.00e-109	386.00
IUUC-Pva-102806	Pteropus vampyrus	77.51	2.00e-112	398.00
IUUC-Rno-105029	Rattus norvegicus	77.51	3.00e-111	394.00
IUUC-Sha-106628	Sarcophilus harrisii	84.34	7.00e-123	432.00
IUUC-Sar-113720	Sorex araneus	69.53	2.00e-100	358.00
IUUC-Sbi-114312	Sorghum bicolor	38.46	5.00e-09	55.10
IUUC-Ssc-115689	Sus scrofa	77.91	1.00e-111	395.00
IUUC-Tgu-116681	Taeniopygia guttata	85.54	1.00e-126	445.00
IUUC-Tru-118517	Takifugu rubripes	78.88	3.00e-107	381.00
IUUC-Tsy-119057	Tarsius syrichta	69.14	5.00e-100	357.00
IUUC-Tni-120353	Tetraodon nigroviridis	75.40	4.00e-108	383.00
IUUC-Tbe-128101	Tupaia belangeri	69.53	2.00e-100	358.00
IUUC-Ttr-128265	Tursiops truncatus	78.31	9.00e-112	395.00
IUUC-Vpa-130717	Vicugna pacos	73.30	3.00e-81	294.00
IUUC-Xtr-132814	Xenopus tropicalis	85.54	2.00e-119	421.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence