iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	8.80e-06	26.8	11	79
E3 activity/RING/RING	1.40e-08	36.2	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwl...asggk......tcPvtrqplteedlvPnltlrrli 65
            +e +CpI     r+Pv++ +G+ + r ++ ++               +cP++++p+++ ++ Pn  l +++
   Q: 11   ADEVNCPICQGTLREPVTIDCGHNFCRGCLTRYCeipG---PeseeslSCPLCKEPFRPGSFRPNWQLANVV 79
           57899*****************************6550...3445569*****************9987776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw...pglknssskefrCPlCr 46
           C+iC+  +++ p++ +CgH f++ Cl ++   pg+   s  + +CPlC+
   Q: 16   CPICQGTLRE-PVTIDCGHNFCRGCLTRYceiPGPE--SEESLSCPLCK 61
           ********99.*******************988888..99********7 PP

Organism

Mus musculus

Functional Description
(View)

Expressed in embryonic liver.

Protein Sequence
(Fasta)

MASAPSVTSL ADEVNCPICQ GTLREPVTID CGHNFCRGCL TRYCEIPGPE SEESLSCPLC 60
KEPFRPGSFR PNWQLANVVE NIERLQLAST RGLEVEDACP EHGEKIYFFC EEDEAQLCVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGACTGT GAGCAGCTTC GGGTGGACAG AAAGTTGCAG TGAGCTCCAG GCCATGGGAA 60
CTGGTCCAGA GAGTTAACTT ATGGTGCTTT GAGCCCCTGG GCCTTCCTCC TCTATTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0008270--F:zinc ion binding
GO:0030218--P:erythrocyte differentiation
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

mmu:19824

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002355	Ailuropoda melanoleuca	83.12	0.00e+00	774.00
IUUC-Bta-012587	Bos taurus	81.56	0.00e+00	771.00
IUUC-Cja-018721	Callithrix jacchus	84.17	0.00e+00	798.00
IUUC-Cfa-020759	Canis familiaris	81.05	0.00e+00	744.00
IUUC-Cpo-022485	Cavia porcellus	71.52	0.00e+00	657.00
IUUC-Csa-023679	Chlorocebus sabaeus	84.58	0.00e+00	801.00
IUUC-Cho-024918	Choloepus hoffmanni	67.50	1.00e-92	332.00
IUUC-Dno-028912	Dasypus novemcinctus	73.96	0.00e+00	715.00
IUUC-Dor-030459	Dipodomys ordii	76.49	0.00e+00	741.00
IUUC-Ete-032226	Echinops telfairi	80.71	1.00e-156	545.00
IUUC-Eca-034379	Equus caballus	82.92	0.00e+00	803.00
IUUC-Eeu-035312	Erinaceus europaeus	77.08	0.00e+00	744.00
IUUC-Fca-036106	Felis catus	77.92	0.00e+00	724.00
IUUC-Ggo-045433	Gorilla gorilla	84.38	0.00e+00	827.00
IUUC-Hsa-046260	Homo sapiens	84.38	0.00e+00	805.00
IUUC-Itr-048465	Ictidomys tridecemlineatus	81.06	0.00e+00	759.00
IUUC-Laf-054405	Loxodonta africana	84.17	0.00e+00	821.00
IUUC-Mcc-055599	Macaca mulatta	84.79	0.00e+00	805.00
IUUC-Meu-056471	Macropus eugenii	63.20	3.00e-113	401.00
IUUC-Mmr-061779	Microcebus murinus	72.59	0.00e+00	681.00
IUUC-Mdo-062384	Monodelphis domestica	72.88	0.00e+00	689.00
IUUC-Mpu-066787	Mustela putorius furo	80.21	0.00e+00	742.00
IUUC-Mlu-067590	Myotis lucifugus	72.82	5.00e-115	407.00
IUUC-Nle-069295	Nomascus leucogenys	84.79	0.00e+00	809.00
IUUC-Oan-072904	Ornithorhynchus anatinus	40.75	4.00e-79	288.00
IUUC-Ocu-074896	Oryctolagus cuniculus	85.18	0.00e+00	631.00
IUUC-Oga-088589	Otolemur garnettii	82.92	0.00e+00	778.00
IUUC-Oar-089521	Ovis aries	81.21	0.00e+00	754.00
IUUC-Ptr-090905	Pan troglodytes	83.75	0.00e+00	816.00
IUUC-Pan-092682	Papio anubis	85.00	0.00e+00	800.00
IUUC-Pab-098559	Pongo abelii	84.24	7.00e-173	599.00
IUUC-Pca-100591	Procavia capensis	73.33	0.00e+00	681.00
IUUC-Pva-103067	Pteropus vampyrus	82.29	0.00e+00	757.00
IUUC-Rno-105824	Rattus norvegicus	93.66	0.00e+00	920.00
IUUC-Sha-107385	Sarcophilus harrisii	73.62	0.00e+00	715.00
IUUC-Sar-113541	Sorex araneus	83.28	2.00e-146	511.00
IUUC-Ssc-115893	Sus scrofa	82.54	0.00e+00	794.00
IUUC-Tsy-119290	Tarsius syrichta	84.27	2.00e-155	541.00
IUUC-Tbe-127565	Tupaia belangeri	81.14	2.00e-109	389.00
IUUC-Ttr-128456	Tursiops truncatus	81.88	0.00e+00	763.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence