iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020060

Ensembl Protein ID

ENSCAFP00000012903.3

UniProt Accession

E2RSH8; E2RSH8_CANLF

Genbank Protein ID

ENSCAFP00000012903

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03013921

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008755.3	ENSCAFT00000013946.3	ENSCAFP00000012903.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-13	50.2	88	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++  ++++++W+ + +  +g+ G +P+n+v+ 
   Q: 88   TFVALYDYESRTETDLSFKKGERLQIV--NNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
           5789***********************..8999*********************975 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGSNKSKPKD ASQRRRSLEP AENTHGGGGG AFPTSQTPSK PASADGHRGP STAFPSAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACAGAAG CTCAGAGAAG TGAAGTGACC TTCCCAGCTA TGAGAGAGGG CATGCCAGGA 60
TTTGAGACCA GGTAAGCCTG TATTTTTTCT TAAAAGGAAA AGAAAAAGGG ACCCCTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0070851--F:growth factor receptor binding
GO:0020037--F:heme binding
GO:0051427--F:hormone receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0050847--P:progesterone receptor signaling pathway
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0051726--P:regulation of cell cycle
GO:0060491--P:regulation of cell projection assembly
GO:0042127--P:regulation of cell proliferation
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0071801--P:regulation of podosome assembly
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	98.71	0.00e+00	1108.00
IUUC-Aca-004237	Anolis carolinensis	92.35	0.00e+00	1029.00
IUUC-Aly-005712	Arabidopsis lyrata	35.63	3.00e-19	90.90
IUUC-Ath-007146	Arabidopsis thaliana	31.91	3.00e-22	100.00
IUUC-Ame-011887	Astyanax mexicanus	79.52	0.00e+00	887.00
IUUC-Bta-012982	Bos taurus	97.23	0.00e+00	1083.00
IUUC-Bdi-014324	Brachypodium distachyon	35.11	5.00e-23	103.00
IUUC-Bol-016049	Brassica oleracea	34.68	2.00e-17	84.30
IUUC-Cja-019995	Callithrix jacchus	97.60	0.00e+00	1088.00
IUUC-Cpo-021557	Cavia porcellus	95.34	0.00e+00	1053.00
IUUC-Csa-023711	Chlorocebus sabaeus	97.79	0.00e+00	1088.00
IUUC-Cin-025390	Ciona intestinalis	70.54	0.00e+00	665.00
IUUC-Csv-026029	Ciona savignyi	66.05	0.00e+00	636.00
IUUC-Dre-028491	Danio rerio	83.43	0.00e+00	890.00
IUUC-Dno-029651	Dasypus novemcinctus	92.57	0.00e+00	1038.00
IUUC-Ete-033170	Echinops telfairi	96.29	0.00e+00	912.00
IUUC-Eca-033970	Equus caballus	92.75	0.00e+00	1004.00
IUUC-Fca-036113	Felis catus	100.00	0.00e+00	1119.00
IUUC-Fal-036785	Ficedula albicollis	93.36	0.00e+00	1047.00
IUUC-Gga-040899	Gallus gallus	93.84	0.00e+00	1050.00
IUUC-Gac-042332	Gasterosteus aculeatus	81.67	0.00e+00	894.00
IUUC-Gma-043938	Glycine max	34.34	1.00e-22	102.00
IUUC-Ggo-044829	Gorilla gorilla	83.76	0.00e+00	895.00
IUUC-Hsa-046192	Homo sapiens	97.79	0.00e+00	1089.00
IUUC-Hvu-047855	Hordeum vulgare	30.71	2.00e-22	100.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	96.86	0.00e+00	1067.00
IUUC-Lch-049892	Latimeria chalumnae	86.90	0.00e+00	968.00
IUUC-Loc-052812	Lepisosteus oculatus	82.42	0.00e+00	897.00
IUUC-Laf-053977	Loxodonta africana	97.60	0.00e+00	1099.00
IUUC-Mcc-055159	Macaca mulatta	95.84	0.00e+00	1083.00
IUUC-Mtr-058733	Medicago truncatula	34.09	5.00e-23	103.00
IUUC-Mga-060135	Meleagris gallopavo	93.36	0.00e+00	1046.00
IUUC-Mmr-061168	Microcebus murinus	95.12	0.00e+00	1083.00
IUUC-Mdo-063030	Monodelphis domestica	90.42	0.00e+00	1030.00
IUUC-Mmu-063893	Mus musculus	96.86	0.00e+00	1087.00
IUUC-Mpu-066411	Mustela putorius furo	100.00	0.00e+00	1119.00
IUUC-Mlu-068139	Myotis lucifugus	97.05	0.00e+00	1077.00
IUUC-Nle-070178	Nomascus leucogenys	95.20	0.00e+00	1031.00
IUUC-Ont-072130	Oreochromis niloticus	81.13	0.00e+00	904.00
IUUC-Ocu-074403	Oryctolagus cuniculus	95.77	0.00e+00	1061.00
IUUC-Oni-082734	Oryza nivara	34.25	2.00e-23	104.00
IUUC-Ola-086527	Oryzias latipes	80.98	0.00e+00	906.00
IUUC-Oga-088493	Otolemur garnettii	97.60	0.00e+00	1083.00
IUUC-Oar-090279	Ovis aries	97.60	0.00e+00	1085.00
IUUC-Ptr-091050	Pan troglodytes	97.79	0.00e+00	1089.00
IUUC-Pan-091862	Papio anubis	98.88	0.00e+00	1095.00
IUUC-Psi-093071	Pelodiscus sinensis	94.03	0.00e+00	1051.00
IUUC-Pfo-096578	Poecilia formosa	81.49	0.00e+00	915.00
IUUC-Pab-097902	Pongo abelii	95.66	0.00e+00	1081.00
IUUC-Pop-099554	Populus trichocarpa	32.42	3.00e-23	103.00
IUUC-Ppe-102072	Prunus persica	34.89	3.00e-26	114.00
IUUC-Pva-103176	Pteropus vampyrus	83.21	0.00e+00	904.00
IUUC-Rno-105847	Rattus norvegicus	97.05	0.00e+00	1088.00
IUUC-Sha-107539	Sarcophilus harrisii	93.47	0.00e+00	1044.00
IUUC-Stu-112331	Solanum tuberosum	32.00	2.00e-22	100.00
IUUC-Sbi-114480	Sorghum bicolor	35.78	1.00e-23	105.00
IUUC-Ssc-115762	Sus scrofa	97.08	0.00e+00	1085.00
IUUC-Tru-117849	Takifugu rubripes	81.14	0.00e+00	878.00
IUUC-Tni-120843	Tetraodon nigroviridis	81.65	0.00e+00	912.00
IUUC-Tae-123192	Triticum aestivum	30.71	8.00e-22	99.40
IUUC-Ttr-128702	Tursiops truncatus	92.44	0.00e+00	1022.00
IUUC-Vvi-131181	Vitis vinifera	33.21	4.00e-22	100.00
IUUC-Xtr-132291	Xenopus tropicalis	87.92	0.00e+00	952.00
IUUC-Xma-133134	Xiphophorus maculatus	81.13	0.00e+00	912.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence