• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Bta-013543
UUCD1 version UUC-BoT-00420
Ensembl Protein ID ENSBTAP00000017277.4
UniProt Accession Q08DI6; RNF11_BOVIN
Genbank Protein ID AAI23729.1
Protein Name RING finger protein 11
Genbank Nucleotide ID BC123728
Gene Name RNF11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000012996.4 ENSBTAT00000017277.4 ENSBTAP00000017277.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 4.70e-09 36.8 60 100
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+ df   d+ ++lpC H++h+dC+  w       +++f+CP C
   Q: 60   CVICMMDFvyGDPIRFLPCMHIYHLDCIDDW------LMRSFTCPSC 100
           ********99888******************......********** PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity).
 Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome (By similarity).
Protein Sequence
(Fasta)
YQEQVPVPVY HPTPSQTRLA TQLTEEEQIR IAQRIGLIQH LPKGVYDPGR DGSEKKIREC 60
VICMMDFVYG DPIRFLPCMH IYHLDCIDDW LMRSFTCPSC MEPVDAALLS SYETN 115
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013543|E3,RING|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TATCAGGAAT GAATATGTCT GTGTTATGTG GTTTTCCTAT GGAAATACTT CAAGTAACAT 60
TCCATGCCAG TTTTACTGTA AACCTTGTTT TTATATCCTT TAACAGTAAG TCAGATATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013543|E3,RING|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG bta:522791
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001762 Ailuropoda melanoleuca 100.00 7.00e-61 225.00
IUUC-Apl-003879 Anas platyrhynchos 100.00 1.00e-64 237.00
IUUC-Aca-004887 Anolis carolinensis 100.00 1.00e-58 218.00
IUUC-Ame-011194 Astyanax mexicanus 92.79 4.00e-60 223.00
IUUC-Cel-018152 Caenorhabditis elegans 47.83 9.00e-22 96.30
IUUC-Cja-019172 Callithrix jacchus 100.00 9.00e-59 218.00
IUUC-Cfa-020423 Canis familiaris 100.00 7.00e-64 235.00
IUUC-Cpo-021457 Cavia porcellus 100.00 9.00e-59 218.00
IUUC-Csa-024165 Chlorocebus sabaeus 100.00 9.00e-59 218.00
IUUC-Cho-024439 Choloepus hoffmanni 99.13 1.00e-65 241.00
IUUC-Cin-025246 Ciona intestinalis 79.66 4.00e-25 105.00
IUUC-Csv-026239 Ciona savignyi 61.76 6.00e-35 139.00
IUUC-Dre-027392 Danio rerio 94.59 5.00e-61 226.00
IUUC-Dno-029468 Dasypus novemcinctus 100.00 1.00e-64 237.00
IUUC-Dor-030265 Dipodomys ordii 100.00 9.00e-59 218.00
IUUC-Dme-032121 Drosophila melanogaster 65.59 3.00e-35 140.00
IUUC-Ete-032526 Echinops telfairi 100.00 9.00e-59 218.00
IUUC-Eca-033516 Equus caballus 100.00 9.00e-59 218.00
IUUC-Eeu-035261 Erinaceus europaeus 100.00 1.00e-64 237.00
IUUC-Fca-036029 Felis catus 100.00 9.00e-59 218.00
IUUC-Fal-036620 Ficedula albicollis 99.13 1.00e-65 240.00
IUUC-Gmo-038539 Gadus morhua 94.50 2.00e-60 224.00
IUUC-Gga-040240 Gallus gallus 100.00 1.00e-58 218.00
IUUC-Gac-041863 Gasterosteus aculeatus 94.59 1.00e-60 224.00
IUUC-Ggo-045517 Gorilla gorilla 100.00 9.00e-59 218.00
IUUC-Hsa-046313 Homo sapiens 100.00 9.00e-59 218.00
IUUC-Itr-048979 Ictidomys tridecemlineatus 99.03 3.00e-58 216.00
IUUC-Lch-050201 Latimeria chalumnae 90.43 5.00e-60 222.00
IUUC-Loc-052731 Lepisosteus oculatus 97.14 4.00e-59 219.00
IUUC-Laf-053374 Loxodonta africana 100.00 3.00e-65 239.00
IUUC-Mcc-055336 Macaca mulatta 100.00 9.00e-59 218.00
IUUC-Meu-055960 Macropus eugenii 99.12 2.00e-64 236.00
IUUC-Mla-059167 Melampsora laricipopulina 45.61 2.00e-09 58.20
IUUC-Mga-059363 Meleagris gallopavo 100.00 1.00e-64 237.00
IUUC-Mmr-061651 Microcebus murinus 100.00 9.00e-59 218.00
IUUC-Mdo-062554 Monodelphis domestica 80.00 5.00e-55 206.00
IUUC-Mmu-064330 Mus musculus 99.07 3.00e-61 227.00
IUUC-Mpu-065844 Mustela putorius furo 100.00 9.00e-59 218.00
IUUC-Mlu-067557 Myotis lucifugus 100.00 9.00e-59 218.00
IUUC-Nle-069160 Nomascus leucogenys 100.00 1.00e-64 237.00
IUUC-Opr-070708 Ochotona princeps 100.00 1.00e-58 218.00
IUUC-Ont-071784 Oreochromis niloticus 96.40 1.00e-61 228.00
IUUC-Oan-073071 Ornithorhynchus anatinus 98.25 8.00e-64 234.00
IUUC-Ocu-074236 Oryctolagus cuniculus 100.00 9.00e-59 218.00
IUUC-Ola-086848 Oryzias latipes 94.78 2.00e-63 234.00
IUUC-Oga-088630 Otolemur garnettii 81.71 1.00e-36 145.00
IUUC-Oar-089615 Ovis aries 100.00 9.00e-59 218.00
IUUC-Ptr-091459 Pan troglodytes 100.00 9.00e-59 218.00
IUUC-Pan-092848 Papio anubis 100.00 9.00e-59 218.00
IUUC-Psi-092968 Pelodiscus sinensis 100.00 1.00e-58 218.00
IUUC-Pfo-096923 Poecilia formosa 95.65 9.00e-64 235.00
IUUC-Pab-098483 Pongo abelii 100.00 9.00e-59 218.00
IUUC-Pca-100978 Procavia capensis 100.00 3.00e-30 123.00
IUUC-Pva-102550 Pteropus vampyrus 100.00 9.00e-59 218.00
IUUC-Rno-105946 Rattus norvegicus 100.00 1.00e-58 218.00
IUUC-Sha-106723 Sarcophilus harrisii 99.12 7.00e-65 238.00
IUUC-Sar-113209 Sorex araneus 100.00 9.00e-59 218.00
IUUC-Sbi-114216 Sorghum bicolor 40.00 2.00e-11 62.40
IUUC-Ssc-115813 Sus scrofa 100.00 9.00e-59 218.00
IUUC-Tgu-117220 Taeniopygia guttata 100.00 3.00e-65 239.00
IUUC-Tru-118754 Takifugu rubripes 94.59 3.00e-61 227.00
IUUC-Tsy-118863 Tarsius syrichta 100.00 1.00e-64 237.00
IUUC-Tni-119702 Tetraodon nigroviridis 94.59 2.00e-61 227.00
IUUC-Tbe-127266 Tupaia belangeri 100.00 3.00e-22 95.90
IUUC-Ttr-128337 Tursiops truncatus 100.00 9.00e-59 218.00
IUUC-Vpa-130786 Vicugna pacos 100.00 1.00e-64 237.00
IUUC-Xtr-132840 Xenopus tropicalis 99.05 6.00e-60 222.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved