iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
AREsite	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.20e-13	51.0	185	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++s++ SLq+LC+++I++c++ + +   dkLPLP +L+++L+++++
   Q: 185  RPSKVLSLQDLCCRTIVSCTPVHLV---DKLPLPIALRSHLKSFSM 227
           6899******************888...***************976 PP

Organism

Homo sapiens

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGTAE SPYSHLGGID YKTTTILLDG 60
QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCACAACCT TGCTGGTCTG GCCCAGGCGG GGGGCGGGGC CAGCACGATG AGCGCCCCGG 60
GCAGCCCCGA CCAGGCCTAC GACTTCCTGC TCAAGTTCCT GCTGGTGGGC GACAGGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0209--Deafness
KW-0225--Disease mutation
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0991--Mental retardation
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR001496--SOCS_box

PROSITE

PS51419--RAB
PS50225--SOCS

Pfam

PF00071--Ras
PF07525--SOCS_box

SMART

SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0005525--F:GTP binding
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

hsa:282808

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-018870	Callithrix jacchus	95.68	3.00e-159	553.00
IUUC-Csa-023202	Chlorocebus sabaeus	97.48	5.00e-162	563.00
IUUC-Ggo-045012	Gorilla gorilla	98.56	1.00e-163	568.00
IUUC-Mcc-055387	Macaca mulatta	98.56	9.00e-164	568.00
IUUC-Nle-069216	Nomascus leucogenys	98.56	1.00e-163	568.00
IUUC-Ptr-091475	Pan troglodytes	99.28	1.00e-164	572.00
IUUC-Pan-092514	Papio anubis	98.56	9.00e-164	568.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence