iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046604

Ensembl Protein ID

ENSP00000228495.6

UniProt Accession

Q9H3F6; Q53HN2; Q59FV1; Q6PL47; Q96SU0; BACD3_HUMAN

Genbank Protein ID

AAO47716.1; AAG39279.1; AAT09002.1; BAB55188.1; BAD92595.1; BAD96268.1; AAH40062.1

Protein Name

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10; Potassium channel tetramerization domain-containing protein 10

Genbank Nucleotide ID

AY205299; AF113208; AY597809; AK027543; AB209358; AK222548; AC007570

Gene Name

KCTD10; ULR061; MSTP028

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000110906.12	ENST00000228495.10	ENSP00000228495.6
ENSG00000110906.12	ENST00000440541.6	ENSP00000390321.2
ENSG00000110906.12	ENST00000537165.5	ENSP00000474497.1
ENSG00000110906.12	ENST00000540411.5	ENSP00000441672.1
ENSG00000110906.12	ENST00000541077.1	ENSP00000474870.1
ENSG00000110906.12	ENST00000542262.5	ENSP00000437348.1
ENSG00000110906.12	ENST00000542858.1	ENSP00000445129.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.60e-08	35.8	34	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 3    vilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           v l+vgg  + ++  +L+ +  +++a+f++ +e  ++s++ + i+ +  ++f ++l++l+ g ++++e
   Q: 34   VKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEvLTDSEGWILID-RCGKHFGTILNYLRDGAVPLPE 100
           99*******************************************.******************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Protein Sequence
(Fasta)

MEEMSGESVV SSAVPAAATR TTSFKGTSPS SKYVKLNVGG ALYYTTMQTL TKQDTMLKAM 60
FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE SRREIEELLA EAKYYLVQGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACCTTGCC TCCCCTCTGG CAGCTGAAAT AGCGGAGGTG GGATAAATGC CCTCCCCAGC 60
CGAGAAAAGC TGGAACCCAC TCCGGCCGGG GAGGCTGGAA AGAAAACTGG CCCCTAGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

PROSITE

PS50097--BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005112--F:Notch binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:83892

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001542	Ailuropoda melanoleuca	98.41	1.00e-164	572.00
IUUC-Bta-013372	Bos taurus	98.63	1.00e-163	568.00
IUUC-Cel-018444	Caenorhabditis elegans	36.32	4.00e-29	121.00
IUUC-Cja-019804	Callithrix jacchus	98.72	1.00e-164	572.00
IUUC-Cfa-020438	Canis familiaris	100.00	3.00e-166	577.00
IUUC-Cpo-022204	Cavia porcellus	98.09	6.00e-165	573.00
IUUC-Csa-024214	Chlorocebus sabaeus	98.63	1.00e-163	568.00
IUUC-Cin-025494	Ciona intestinalis	74.17	2.00e-108	385.00
IUUC-Csv-026325	Ciona savignyi	72.87	2.00e-110	391.00
IUUC-Dre-027582	Danio rerio	94.35	1.00e-160	558.00
IUUC-Dno-029910	Dasypus novemcinctus	97.95	2.00e-161	561.00
IUUC-Dor-030244	Dipodomys ordii	97.95	1.00e-162	565.00
IUUC-Dme-031829	Drosophila melanogaster	70.00	6.00e-104	370.00
IUUC-Eca-033705	Equus caballus	98.41	2.00e-165	574.00
IUUC-Fca-035701	Felis catus	98.63	1.00e-163	568.00
IUUC-Fal-036623	Ficedula albicollis	98.71	6.00e-162	563.00
IUUC-Gmo-039520	Gadus morhua	94.02	1.00e-157	548.00
IUUC-Gga-040287	Gallus gallus	90.97	3.00e-143	501.00
IUUC-Gac-041695	Gasterosteus aculeatus	94.02	5.00e-157	546.00
IUUC-Gma-043357	Glycine max	46.49	3.00e-20	92.00
IUUC-Itr-048792	Ictidomys tridecemlineatus	96.58	2.00e-155	541.00
IUUC-Lch-050521	Latimeria chalumnae	97.74	4.00e-173	600.00
IUUC-Loc-052261	Lepisosteus oculatus	94.87	1.00e-170	592.00
IUUC-Laf-054190	Loxodonta africana	98.10	8.00e-164	569.00
IUUC-Mcc-054717	Macaca mulatta	98.41	3.00e-164	570.00
IUUC-Meu-056301	Macropus eugenii	98.40	2.00e-165	575.00
IUUC-Mga-060191	Meleagris gallopavo	98.08	2.00e-161	561.00
IUUC-Mmr-060849	Microcebus murinus	98.41	2.00e-164	571.00
IUUC-Mmu-063684	Mus musculus	96.84	4.00e-163	566.00
IUUC-Mpu-066892	Mustela putorius furo	98.63	1.00e-163	568.00
IUUC-Mlu-067537	Myotis lucifugus	99.24	2.00e-155	541.00
IUUC-Nle-069770	Nomascus leucogenys	98.63	1.00e-163	568.00
IUUC-Opr-070517	Ochotona princeps	97.60	3.00e-162	564.00
IUUC-Ont-071872	Oreochromis niloticus	92.97	7.00e-152	529.00
IUUC-Ocu-074821	Oryctolagus cuniculus	97.95	8.00e-163	566.00
IUUC-Ola-086732	Oryzias latipes	93.27	5.00e-164	570.00
IUUC-Oga-088014	Otolemur garnettii	98.29	3.00e-162	564.00
IUUC-Oar-089713	Ovis aries	98.23	3.00e-155	540.00
IUUC-Pan-092149	Papio anubis	98.63	1.00e-163	568.00
IUUC-Psi-093600	Pelodiscus sinensis	99.31	5.00e-157	546.00
IUUC-Pma-094524	Petromyzon marinus	86.07	2.00e-113	401.00
IUUC-Pfo-096431	Poecilia formosa	90.73	7.00e-166	576.00
IUUC-Pab-098442	Pongo abelii	98.63	1.00e-163	568.00
IUUC-Pva-102644	Pteropus vampyrus	98.41	9.00e-166	575.00
IUUC-Ptt-103832	Puccinia triticina	23.21	2.00e+00	27.30
IUUC-Rno-105424	Rattus norvegicus	97.14	6.00e-165	573.00
IUUC-Sce-106193	Saccharomyces cerevisiae	32.69	9.30e+00	25.80
IUUC-Sha-107257	Sarcophilus harrisii	98.08	4.00e-161	560.00
IUUC-Sar-113351	Sorex araneus	92.99	3.00e-153	534.00
IUUC-Ssc-116078	Sus scrofa	98.29	3.00e-162	564.00
IUUC-Tgu-116771	Taeniopygia guttata	98.40	2.00e-162	565.00
IUUC-Tru-117556	Takifugu rubripes	94.53	4.00e-167	580.00
IUUC-Tni-120749	Tetraodon nigroviridis	94.23	2.00e-168	584.00
IUUC-Xtr-131958	Xenopus tropicalis	95.54	4.00e-162	563.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence