iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094074

Ensembl Protein ID

ENSPSIP00000012140.1

UniProt Accession

K7FVT0; K7FVT0_PELSI

Genbank Protein ID

ENSPSIP00000012140

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01018241

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010953.1	ENSPSIT00000012198.1	ENSPSIP00000012140.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-128	428.2	220	555

Active Site

Position(s)	Description	Evidence
524	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 220  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 307
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 308  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 392
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 393  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 480
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 481  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 555
           ******************************99999**************************************76 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MEEPAPYTDS TGAAGGGNCR FVESPNQDQR LQAQRLRNPE VRGHVQTPQN RPHGHQSPDL 60
PEGYEQRTTV QGQVYFLHTQ TGVSTWHDPR IPRDLNSVNC DELGPLPPGW EVRSTVSGRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAGC CAGCACCATA TACCGATAGT ACTGGTGCTG CTGGTGGTGG GAATTGTAGG 60
TTTGTGGAAT CTCCTAATCA AGATCAGAGG CTTCAAGCAC AGCGACTTCG AAATCCTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004155	Anas platyrhynchos	95.16	0.00e+00	1134.00
IUUC-Cpo-022531	Cavia porcellus	93.31	0.00e+00	1117.00
IUUC-Cho-024963	Choloepus hoffmanni	69.48	2.00e-170	592.00
IUUC-Dme-031740	Drosophila melanogaster	71.18	4.00e-176	611.00
IUUC-Eca-034125	Equus caballus	93.31	0.00e+00	1118.00
IUUC-Eeu-034705	Erinaceus europaeus	97.63	0.00e+00	947.00
IUUC-Gmo-039486	Gadus morhua	81.25	0.00e+00	874.00
IUUC-Gga-040218	Gallus gallus	96.65	0.00e+00	1139.00
IUUC-Lch-049801	Latimeria chalumnae	92.64	0.00e+00	1061.00
IUUC-Mcc-055479	Macaca mulatta	97.85	0.00e+00	1136.00
IUUC-Mdo-063005	Monodelphis domestica	99.46	0.00e+00	1154.00
IUUC-Pca-100379	Procavia capensis	72.57	0.00e+00	637.00
IUUC-Sha-107216	Sarcophilus harrisii	95.02	0.00e+00	1141.00
IUUC-Sar-113250	Sorex araneus	95.65	0.00e+00	820.00
IUUC-Tni-120829	Tetraodon nigroviridis	82.62	0.00e+00	928.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence