iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034039

Ensembl Protein ID

ENSECAP00000019669.1

UniProt Accession

F6YV16; F6YV16_HORSE

Protein Name

Uncharacterized protein

Gene Name

DDX58

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021989.1	ENSECAT00000023725.1	ENSECAP00000019669.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	7.70e-44	148.3	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 1    tdeeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL..vqkegWfrefl 73
           ++ e+r+ l ++ d+vrk+Ld+t +l+ y++++++   +++ +a++++kg m+aa l+L  L  +q+egWfr+fl
   Q: 1    MTAEQRRNLHAFGDYVRKTLDPTHILS-YMAPWFRDDMVQYVQAEKNNKGTMEAASLFLRYLleLQEEGWFRGFL 74
           5679***********************.*********************************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MTAEQRRNLH AFGDYVRKTL DPTHILSYMA PWFRDDMVQY VQAEKNNKGT MEAASLFLRY 60
LLELQEEGWF RGFLDALDQA GYSGLYEAIE SWDFQKIEKL EEHRALLRRL QPVFKTRVNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTTAAAG GCAGCGGGGT GCGGGTGAGG CTGGGACTCG CGGGACGCCC AGCCGCCGTC 60
ATGACCGCCG AGCAGCGCCG GAATCTGCAC GCCTTCGGGG ACTATGTCCG GAAGACCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011545--DEAD/DEAH_box_helicase_dom
IPR011029--DEATH-like_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00270--DEAD
PF00271--Helicase_C
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005923--C:bicellular tight junction
GO:0005829--C:cytosol
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0003690--F:double-stranded DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016817--F:hydrolase activity, acting on acid anhydrides
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0009597--P:detection of virus
GO:0045087--P:innate immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0032725--P:positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0043330--P:response to exogenous dsRNA
GO:0039529--P:RIG-I signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001898	Ailuropoda melanoleuca	83.12	0.00e+00	1536.00
IUUC-Apl-003966	Anas platyrhynchos	54.53	0.00e+00	942.00
IUUC-Aca-004499	Anolis carolinensis	47.32	0.00e+00	818.00
IUUC-Ame-011950	Astyanax mexicanus	42.99	0.00e+00	707.00
IUUC-Bta-012489	Bos taurus	81.91	0.00e+00	1502.00
IUUC-Cel-018230	Caenorhabditis elegans	29.73	3.00e-71	263.00
IUUC-Cja-018716	Callithrix jacchus	81.30	0.00e+00	1519.00
IUUC-Cfa-020269	Canis familiaris	83.32	0.00e+00	1563.00
IUUC-Cpo-022507	Cavia porcellus	74.19	0.00e+00	1389.00
IUUC-Csa-024209	Chlorocebus sabaeus	81.62	0.00e+00	1537.00
IUUC-Cho-025104	Choloepus hoffmanni	73.98	0.00e+00	1190.00
IUUC-Cin-025792	Ciona intestinalis	32.13	2.00e-85	310.00
IUUC-Dno-028954	Dasypus novemcinctus	77.87	0.00e+00	1416.00
IUUC-Eeu-035009	Erinaceus europaeus	71.88	0.00e+00	953.00
IUUC-Fca-036169	Felis catus	83.96	0.00e+00	1577.00
IUUC-Fal-037579	Ficedula albicollis	53.78	0.00e+00	926.00
IUUC-Ggo-045318	Gorilla gorilla	79.55	0.00e+00	1385.00
IUUC-Hsa-046671	Homo sapiens	82.16	0.00e+00	1513.00
IUUC-Itr-047996	Ictidomys tridecemlineatus	77.65	0.00e+00	1423.00
IUUC-Lch-050461	Latimeria chalumnae	50.32	0.00e+00	892.00
IUUC-Loc-052582	Lepisosteus oculatus	47.91	0.00e+00	842.00
IUUC-Laf-054324	Loxodonta africana	80.06	0.00e+00	1465.00
IUUC-Mcc-055390	Macaca mulatta	81.08	0.00e+00	1525.00
IUUC-Meu-056365	Macropus eugenii	55.59	1.00e-177	616.00
IUUC-Mpo-057328	Magnaporthe poae	31.71	7.00e-01	30.00
IUUC-Mvi-060497	Microbotryum violaceum	26.57	3.00e-27	118.00
IUUC-Mmr-061407	Microcebus murinus	81.41	0.00e+00	1548.00
IUUC-Mmu-063939	Mus musculus	74.70	0.00e+00	1372.00
IUUC-Mpu-066226	Mustela putorius furo	82.47	0.00e+00	1444.00
IUUC-Mlu-068092	Myotis lucifugus	82.28	0.00e+00	1490.00
IUUC-Nfi-068405	Neosartorya fischeri	25.48	9.00e-27	116.00
IUUC-Opr-070246	Ochotona princeps	68.53	0.00e+00	682.00
IUUC-Oan-072742	Ornithorhynchus anatinus	61.17	0.00e+00	970.00
IUUC-Ocu-073959	Oryctolagus cuniculus	75.57	0.00e+00	1425.00
IUUC-Oga-089173	Otolemur garnettii	81.06	0.00e+00	1508.00
IUUC-Oar-089369	Ovis aries	81.72	0.00e+00	1470.00
IUUC-Ptr-091032	Pan troglodytes	82.16	0.00e+00	1513.00
IUUC-Pan-092383	Papio anubis	81.53	0.00e+00	1528.00
IUUC-Psi-093432	Pelodiscus sinensis	55.96	0.00e+00	1056.00
IUUC-Pma-094367	Petromyzon marinus	41.97	6.00e-115	407.00
IUUC-Pab-098416	Pongo abelii	82.17	0.00e+00	1420.00
IUUC-Pca-101006	Procavia capensis	80.51	0.00e+00	658.00
IUUC-Pva-102966	Pteropus vampyrus	83.62	0.00e+00	1553.00
IUUC-Pgr-103529	Puccinia graminis	27.41	8.00e-26	113.00
IUUC-Rno-105059	Rattus norvegicus	74.66	0.00e+00	888.00
IUUC-Ssl-108450	Sclerotinia sclerotiorum	29.59	9.00e-05	43.90
IUUC-Sar-113202	Sorex araneus	68.28	0.00e+00	1049.00
IUUC-Ssc-116120	Sus scrofa	80.56	0.00e+00	1458.00
IUUC-Tgu-117314	Taeniopygia guttata	52.74	0.00e+00	939.00
IUUC-Tsy-119453	Tarsius syrichta	79.42	0.00e+00	851.00
IUUC-Tre-122194	Trichoderma reesei	27.74	2.00e-20	95.10
IUUC-Ttr-128421	Tursiops truncatus	79.08	0.00e+00	1240.00
IUUC-Vpa-130602	Vicugna pacos	81.31	0.00e+00	1426.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence