iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061801

UUCD1 version

UUC-MoD-01116

Ensembl Protein ID

ENSMODP00000002705.2

UniProt Accession

F7DG08; F7DG08_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002220.3	ENSMODT00000002760.3	ENSMODP00000002705.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-109	366.2	761	1091

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +fsg
   Q: 761  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnFYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFSG 847
           7******************************667889************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 848  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 934
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 935  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCKTRRDSMKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1016
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    k+Y+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v +   s aY+lfY+
   Q: 1017 EsLDLSQYVIGPKNN---LKRYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVRS---SAAYILFYT 1091
           ***********9988...69*************************88888*******************...********8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MPAVASVPKE LYLGSSLKEL NKKTEVKAEK ISTKNYVQSA LKIFRTAEEC RLDRDEEKAY 60
VLYMKYVAVY NLIKKRPDFK QQQDYFHSML GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGAGCTT CTTTTAAAGA ATTCCACCCA TTGTAAAAGG GTGAAAGTAG ATAACTATTC 60
ACCATGCCTG CTGTTGCTTC AGTACCTAAA GAGCTCTACC TTGGATCCTC ATTGAAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100026038

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	80.32	0.00e+00	1632.00
IUUC-Apl-003226	Anas platyrhynchos	68.69	0.00e+00	1459.00
IUUC-Aca-004936	Anolis carolinensis	66.61	0.00e+00	1296.00
IUUC-Ago-007959	Ashbya gossypii	35.89	1.00e-54	208.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	1.00e-50	195.00
IUUC-Afl-008604	Aspergillus flavus	30.77	2.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.32	8.00e-50	192.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	1.00e-49	191.00
IUUC-Ang-009844	Aspergillus niger	31.94	8.00e-49	189.00
IUUC-Aor-010098	Aspergillus oryzae	30.77	7.00e-49	189.00
IUUC-Ate-010585	Aspergillus terreus	30.94	1.00e-48	188.00
IUUC-Ame-010960	Astyanax mexicanus	77.78	5.00e-85	306.00
IUUC-Bta-013008	Bos taurus	84.30	0.00e+00	973.00
IUUC-Bol-015281	Brassica oleracea	38.21	2.00e-47	183.00
IUUC-Bra-017228	Brassica rapa	39.40	1.00e-49	190.00
IUUC-Cel-018482	Caenorhabditis elegans	34.40	1.00e-51	198.00
IUUC-Cja-019173	Callithrix jacchus	88.14	0.00e+00	1022.00
IUUC-Cfa-021243	Canis familiaris	80.88	0.00e+00	1647.00
IUUC-Cpo-021522	Cavia porcellus	78.08	0.00e+00	1569.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	45.22	1.00e-81	296.00
IUUC-Csa-023616	Chlorocebus sabaeus	89.41	0.00e+00	1025.00
IUUC-Cho-024381	Choloepus hoffmanni	68.74	0.00e+00	1373.00
IUUC-Cin-025287	Ciona intestinalis	50.13	4.00e-98	353.00
IUUC-Csv-026253	Ciona savignyi	48.16	3.00e-86	313.00
IUUC-Cne-026821	Cryptococcus neoformans	40.17	2.00e-74	274.00
IUUC-Dre-028440	Danio rerio	71.81	0.00e+00	740.00
IUUC-Dno-029039	Dasypus novemcinctus	88.14	0.00e+00	1043.00
IUUC-Dor-031043	Dipodomys ordii	93.53	2.00e-128	453.00
IUUC-Dse-031463	Dothistroma septosporum	28.36	1.00e-41	165.00
IUUC-Dme-032089	Drosophila melanogaster	45.98	2.00e-83	303.00
IUUC-Ete-033040	Echinops telfairi	73.25	0.00e+00	1379.00
IUUC-Eca-033449	Equus caballus	80.62	0.00e+00	1643.00
IUUC-Eeu-034693	Erinaceus europaeus	93.10	4.00e-128	452.00
IUUC-Fca-035794	Felis catus	96.00	0.00e+00	908.00
IUUC-Fal-037322	Ficedula albicollis	83.70	0.00e+00	916.00
IUUC-Gmo-038584	Gadus morhua	67.14	0.00e+00	664.00
IUUC-Gga-041188	Gallus gallus	85.14	0.00e+00	936.00
IUUC-Gac-041850	Gasterosteus aculeatus	70.62	0.00e+00	737.00
IUUC-Ggo-045565	Gorilla gorilla	89.58	0.00e+00	1032.00
IUUC-Hsa-046438	Homo sapiens	89.41	0.00e+00	1031.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	79.20	0.00e+00	1579.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	8.00e-49	188.00
IUUC-Lch-050485	Latimeria chalumnae	84.48	0.00e+00	875.00
IUUC-Loc-052769	Lepisosteus oculatus	76.39	0.00e+00	795.00
IUUC-Lma-053021	Leptosphaeria maculans	32.53	4.00e-53	203.00
IUUC-Laf-053432	Loxodonta africana	75.15	0.00e+00	1580.00
IUUC-Mcc-055823	Macaca mulatta	89.58	0.00e+00	1033.00
IUUC-Meu-056099	Macropus eugenii	98.14	6.00e-165	575.00
IUUC-Mla-059089	Melampsora laricipopulina	40.49	7.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	85.12	0.00e+00	931.00
IUUC-Mvi-060559	Microbotryum violaceum	39.83	1.00e-77	285.00
IUUC-Mmr-061158	Microcebus murinus	86.59	0.00e+00	1009.00
IUUC-Mmu-063665	Mus musculus	75.42	0.00e+00	1526.00
IUUC-Mpu-066738	Mustela putorius furo	88.10	0.00e+00	1031.00
IUUC-Mlu-067307	Myotis lucifugus	80.09	0.00e+00	1645.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	4.00e-50	193.00
IUUC-Nle-069314	Nomascus leucogenys	89.76	0.00e+00	1035.00
IUUC-Opr-070378	Ochotona princeps	78.36	4.00e-150	526.00
IUUC-Ont-071545	Oreochromis niloticus	76.06	0.00e+00	756.00
IUUC-Oan-073537	Ornithorhynchus anatinus	77.75	0.00e+00	1531.00
IUUC-Ocu-074193	Oryctolagus cuniculus	78.91	0.00e+00	1602.00
IUUC-Ola-086622	Oryzias latipes	74.80	0.00e+00	740.00
IUUC-Oga-088271	Otolemur garnettii	87.18	0.00e+00	999.00
IUUC-Oar-090431	Ovis aries	84.30	0.00e+00	976.00
IUUC-Ptr-091339	Pan troglodytes	81.43	0.00e+00	1708.00
IUUC-Pan-091783	Papio anubis	76.05	0.00e+00	701.00
IUUC-Psi-093187	Pelodiscus sinensis	67.50	1.00e-157	550.00
IUUC-Pma-094626	Petromyzon marinus	57.40	4.00e-143	501.00
IUUC-Pfo-096463	Poecilia formosa	75.66	0.00e+00	754.00
IUUC-Pab-097645	Pongo abelii	89.90	0.00e+00	1032.00
IUUC-Pva-103222	Pteropus vampyrus	67.35	0.00e+00	738.00
IUUC-Pgr-103408	Puccinia graminis	36.04	6.00e-54	206.00
IUUC-Ptt-103699	Puccinia triticina	45.80	2.00e-67	251.00
IUUC-Pte-104348	Pyrenophora teres	29.13	6.00e-40	159.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.39	5.00e-51	196.00
IUUC-Rno-105510	Rattus norvegicus	74.98	0.00e+00	1534.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.99	8.00e-51	195.00
IUUC-Sha-106879	Sarcophilus harrisii	92.22	0.00e+00	1801.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	3.00e-48	186.00
IUUC-Sar-113019	Sorex araneus	74.38	0.00e+00	1534.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	3.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	78.79	0.00e+00	1599.00
IUUC-Tgu-117062	Taeniopygia guttata	84.06	0.00e+00	917.00
IUUC-Tru-117908	Takifugu rubripes	75.87	0.00e+00	749.00
IUUC-Tsy-118867	Tarsius syrichta	80.90	0.00e+00	905.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.04	0.00e+00	731.00
IUUC-Tme-127144	Tuber melanosporum	40.28	5.00e-78	286.00
IUUC-Tbe-127877	Tupaia belangeri	93.46	8.00e-80	292.00
IUUC-Ttr-128580	Tursiops truncatus	87.15	0.00e+00	994.00
IUUC-Uma-129340	Ustilago maydis	36.76	7.00e-71	262.00
IUUC-Vpa-130541	Vicugna pacos	77.95	0.00e+00	1622.00
IUUC-Xtr-132161	Xenopus tropicalis	74.67	0.00e+00	817.00
IUUC-Xma-134271	Xiphophorus maculatus	75.66	0.00e+00	751.00
IUUC-Yli-134561	Yarrowia lipolytica	36.46	5.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence