iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037179

Ensembl Protein ID

ENSFALP00000000206.1

UniProt Accession

U3JBQ2; U3JBQ2_FICAL

Genbank Protein ID

ENSFALP00000000206

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTO01021941

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000000182.1	ENSFALT00000000208.1	ENSFALP00000000206.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.20e-27	95.5	1378	1429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
           vC++C+e++ +++ l++C++C++w+H+aC +l  eee+++  +  + C+ C+
   Q: 1378 VCPFCREKYVEDDLLIQCRHCDRWLHAACDSLFTEEEVEQAADegFDCSACQ 1429
           8*******************************9888888877678******7 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MDEEKVPSEE KDAAAPADGA MASEEMGSAE GDPLKPPEGA SAGPEPESRG MEGPPEAGSP 60
LGRRCALCNC GDWSLHGQRE LQRCEPVPDW PERLVGHEPP DGPGQPPPGP SQLPPEPELV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAAG AGAAGGTGCC CAGCGAGGAG AAGGACGCAG CCGCGCCAGG TGAGCCAGGG 60
CAGGACTTTG GGGAGCTGTC CCTGTTTCCC CTGCGATGGT GACACCCCCT CTGCCCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	65.70	0.00e+00	1229.00
IUUC-Apl-003311	Anas platyrhynchos	73.54	0.00e+00	889.00
IUUC-Aca-005364	Anolis carolinensis	96.34	0.00e+00	1127.00
IUUC-Ame-010612	Astyanax mexicanus	80.66	0.00e+00	1010.00
IUUC-Bta-013011	Bos taurus	65.46	0.00e+00	1248.00
IUUC-Bra-017422	Brassica rapa	31.80	2.00e-26	114.00
IUUC-Cel-018354	Caenorhabditis elegans	36.75	3.00e-62	234.00
IUUC-Cja-019841	Callithrix jacchus	65.81	0.00e+00	1257.00
IUUC-Cfa-021131	Canis familiaris	66.05	0.00e+00	1233.00
IUUC-Cpo-021957	Cavia porcellus	65.65	0.00e+00	1298.00
IUUC-Csa-023722	Chlorocebus sabaeus	65.73	0.00e+00	1234.00
IUUC-Cho-024469	Choloepus hoffmanni	61.29	5.00e-95	344.00
IUUC-Dre-028110	Danio rerio	67.17	0.00e+00	835.00
IUUC-Dno-029932	Dasypus novemcinctus	65.54	0.00e+00	1178.00
IUUC-Dor-030192	Dipodomys ordii	66.57	0.00e+00	1043.00
IUUC-Dme-031590	Drosophila melanogaster	32.32	4.00e-60	227.00
IUUC-Ete-032572	Echinops telfairi	94.78	0.00e+00	942.00
IUUC-Eca-033945	Equus caballus	44.11	9.00e-165	576.00
IUUC-Eeu-034848	Erinaceus europaeus	67.89	0.00e+00	960.00
IUUC-Fca-035424	Felis catus	66.29	0.00e+00	1246.00
IUUC-Gmo-038719	Gadus morhua	82.81	0.00e+00	911.00
IUUC-Gga-040815	Gallus gallus	89.20	0.00e+00	1630.00
IUUC-Gac-042436	Gasterosteus aculeatus	80.04	0.00e+00	996.00
IUUC-Ggo-044711	Gorilla gorilla	65.97	0.00e+00	1245.00
IUUC-Hsa-046567	Homo sapiens	65.89	0.00e+00	1244.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	65.16	0.00e+00	1241.00
IUUC-Lch-050086	Latimeria chalumnae	73.54	0.00e+00	885.00
IUUC-Loc-051979	Lepisosteus oculatus	82.59	0.00e+00	1065.00
IUUC-Laf-054377	Loxodonta africana	73.95	0.00e+00	1558.00
IUUC-Mcc-055577	Macaca mulatta	63.71	0.00e+00	1184.00
IUUC-Meu-055992	Macropus eugenii	94.48	0.00e+00	1080.00
IUUC-Mga-059541	Meleagris gallopavo	73.74	0.00e+00	730.00
IUUC-Mmr-061772	Microcebus murinus	64.35	0.00e+00	1254.00
IUUC-Mdo-062876	Monodelphis domestica	64.27	0.00e+00	780.00
IUUC-Mmu-063903	Mus musculus	64.34	0.00e+00	1204.00
IUUC-Mpu-066700	Mustela putorius furo	66.29	0.00e+00	1244.00
IUUC-Mlu-068180	Myotis lucifugus	66.29	0.00e+00	1260.00
IUUC-Nle-069362	Nomascus leucogenys	65.73	0.00e+00	1235.00
IUUC-Opr-070304	Ochotona princeps	80.88	0.00e+00	918.00
IUUC-Ont-071881	Oreochromis niloticus	62.66	0.00e+00	1360.00
IUUC-Oan-072945	Ornithorhynchus anatinus	73.54	0.00e+00	915.00
IUUC-Ocu-074053	Oryctolagus cuniculus	65.56	0.00e+00	1218.00
IUUC-Ola-086384	Oryzias latipes	53.41	0.00e+00	709.00
IUUC-Oga-088450	Otolemur garnettii	66.32	0.00e+00	1266.00
IUUC-Oar-089975	Ovis aries	63.48	0.00e+00	1149.00
IUUC-Ptr-091073	Pan troglodytes	65.89	0.00e+00	1244.00
IUUC-Pan-092871	Papio anubis	64.39	0.00e+00	1236.00
IUUC-Pma-094252	Petromyzon marinus	48.45	1.00e-98	355.00
IUUC-Pfo-097525	Poecilia formosa	80.66	0.00e+00	983.00
IUUC-Pab-097679	Pongo abelii	66.29	0.00e+00	1269.00
IUUC-Pca-100499	Procavia capensis	64.49	0.00e+00	1231.00
IUUC-Pva-102898	Pteropus vampyrus	66.32	0.00e+00	1257.00
IUUC-Rno-105660	Rattus norvegicus	64.44	0.00e+00	1209.00
IUUC-Sha-107431	Sarcophilus harrisii	66.10	0.00e+00	1201.00
IUUC-Sar-113183	Sorex araneus	75.00	1.00e-93	340.00
IUUC-Sbi-113816	Sorghum bicolor	33.04	2.00e-13	71.20
IUUC-Ssc-115678	Sus scrofa	65.35	0.00e+00	1222.00
IUUC-Tgu-116677	Taeniopygia guttata	75.73	0.00e+00	889.00
IUUC-Tru-117922	Takifugu rubripes	80.04	0.00e+00	1006.00
IUUC-Tsy-118932	Tarsius syrichta	72.85	0.00e+00	926.00
IUUC-Tni-119970	Tetraodon nigroviridis	57.46	0.00e+00	710.00
IUUC-Tur-126568	Triticum urartu	38.24	2.00e-11	64.70
IUUC-Tbe-127625	Tupaia belangeri	89.16	4.00e-133	471.00
IUUC-Ttr-129162	Tursiops truncatus	92.04	0.00e+00	1144.00
IUUC-Vpa-130236	Vicugna pacos	68.37	2.00e-85	312.00
IUUC-Xtr-132455	Xenopus tropicalis	64.71	0.00e+00	1319.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence