iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097525

Ensembl Protein ID

ENSPFOP00000007738.1

UniProt Accession

A0A087XPN5; A0A087XPN5_POEFO

Genbank Protein ID

ENSPFOP00000007738

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AYCK01006651

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000007032.1	ENSPFOT00000007750.1	ENSPFOP00000007738.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.90e-22	79.2	265	314

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           kvC  C+++ged+ ++++C+ C++ +H  Cl+++  ++lp++ +w C++Cr +
   Q: 265  KVCQTCRQPGEDS-KMLVCDACDKGYHTFCLQPA-MDSLPSD-PWKCRRCRVC 314
           58*********87.6*******************.*******.6******965 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MDEQKSNCEE NDSEPTVADD SASGHQPVSL QESSKVSPAA DESGVDATSS STPVECIRAC 60
ALCNCVERSL LGQRELRHFR SSLERPTQKP SAFPLPLPGN DDLSSIGFSD SSCLTALFDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAGC AGAAATCGAA CTGCGAAGAG AATGACTCTG AACCAACAGG TAAAGTTTTC 60
ATGGTATTCC ATTTCATACC TGCTCCAATT AAGCTTTTTC TAATTGATAC TGATTTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	32.14	4.00e-13	70.50
IUUC-Aml-001806	Ailuropoda melanoleuca	79.82	0.00e+00	983.00
IUUC-Aca-005364	Anolis carolinensis	55.85	0.00e+00	1163.00
IUUC-Ame-010612	Astyanax mexicanus	56.25	0.00e+00	1801.00
IUUC-Bta-013011	Bos taurus	79.02	0.00e+00	990.00
IUUC-Cja-019841	Callithrix jacchus	79.51	0.00e+00	987.00
IUUC-Cfa-021131	Canis familiaris	79.51	0.00e+00	988.00
IUUC-Cpo-021957	Cavia porcellus	78.85	0.00e+00	986.00
IUUC-Csa-023722	Chlorocebus sabaeus	79.33	0.00e+00	984.00
IUUC-Dno-029932	Dasypus novemcinctus	79.51	0.00e+00	987.00
IUUC-Ete-032572	Echinops telfairi	80.87	0.00e+00	817.00
IUUC-Eeu-034848	Erinaceus europaeus	55.12	0.00e+00	712.00
IUUC-Fca-035424	Felis catus	79.51	0.00e+00	988.00
IUUC-Fal-037179	Ficedula albicollis	79.89	0.00e+00	968.00
IUUC-Gmo-038719	Gadus morhua	67.81	0.00e+00	1195.00
IUUC-Gga-040815	Gallus gallus	50.34	0.00e+00	682.00
IUUC-Gac-042436	Gasterosteus aculeatus	71.27	0.00e+00	1740.00
IUUC-Ggo-044711	Gorilla gorilla	79.51	0.00e+00	988.00
IUUC-Hsa-046567	Homo sapiens	79.51	0.00e+00	988.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	79.51	0.00e+00	988.00
IUUC-Loc-051979	Lepisosteus oculatus	88.08	0.00e+00	1103.00
IUUC-Laf-054377	Loxodonta africana	64.14	0.00e+00	1317.00
IUUC-Mcc-055577	Macaca mulatta	73.50	0.00e+00	891.00
IUUC-Meu-055992	Macropus eugenii	80.85	0.00e+00	935.00
IUUC-Mmr-061772	Microcebus murinus	79.51	0.00e+00	986.00
IUUC-Mdo-062876	Monodelphis domestica	61.07	1.00e-119	425.00
IUUC-Mmu-063903	Mus musculus	79.79	0.00e+00	979.00
IUUC-Mpu-066700	Mustela putorius furo	79.68	0.00e+00	988.00
IUUC-Mlu-068180	Myotis lucifugus	79.02	0.00e+00	989.00
IUUC-Opr-070304	Ochotona princeps	68.98	0.00e+00	785.00
IUUC-Ont-071881	Oreochromis niloticus	74.01	0.00e+00	2522.00
IUUC-Ocu-074053	Oryctolagus cuniculus	79.51	0.00e+00	985.00
IUUC-Ola-086384	Oryzias latipes	65.04	0.00e+00	2583.00
IUUC-Oga-088450	Otolemur garnettii	64.44	0.00e+00	1337.00
IUUC-Oar-089975	Ovis aries	78.85	0.00e+00	982.00
IUUC-Pan-092871	Papio anubis	79.33	0.00e+00	986.00
IUUC-Pab-097679	Pongo abelii	79.51	0.00e+00	986.00
IUUC-Pca-100499	Procavia capensis	79.51	0.00e+00	988.00
IUUC-Pva-102898	Pteropus vampyrus	78.98	0.00e+00	974.00
IUUC-Rno-105660	Rattus norvegicus	61.85	0.00e+00	1217.00
IUUC-Sha-107431	Sarcophilus harrisii	80.48	0.00e+00	947.00
IUUC-Sbi-114711	Sorghum bicolor	38.16	5.00e-05	40.80
IUUC-Ssc-115678	Sus scrofa	79.22	0.00e+00	979.00
IUUC-Tru-117922	Takifugu rubripes	65.63	0.00e+00	2396.00
IUUC-Tur-126568	Triticum urartu	35.06	4.00e-10	60.50
IUUC-Tbe-127625	Tupaia belangeri	65.46	5.00e-101	365.00
IUUC-Ttr-129162	Tursiops truncatus	78.85	0.00e+00	991.00
IUUC-Xtr-132455	Xenopus tropicalis	57.15	0.00e+00	1149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence