iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101695.8	ENST00000217740.3	ENSP00000217740.3
ENSG00000101695.8	ENST00000580209.1	ENSP00000463935.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17460044; 19380491; 19893624
UBD/Alpha-Helix/UIM	UIM	17990982

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.40e-09	39.6	33	98
E3 activity/RING/RING	1.20e-08	37.0	37	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYK 98
           579******************************99999**********999999999999999986 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca+Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CAVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525).

Protein Sequence
(Fasta)

MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTCATTTT TGCAGCTTAT TGTGATGACA ACAGTGGAGG ATGGTCTTCC ACTTCACCTT 60
AAAAGCGGCT GTTCTCTGAT TATCATTAAG CATGGCCACG CCCGCACTTA ACTTCTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0519--Myristate
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0002039--F:p53 binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:54941

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	91.81	6.00e-127	446.00
IUUC-Aca-004839	Anolis carolinensis	63.48	1.00e-66	245.00
IUUC-Bta-012827	Bos taurus	90.04	6.00e-124	436.00
IUUC-Cja-018794	Callithrix jacchus	93.53	9.00e-128	449.00
IUUC-Cfa-021234	Canis familiaris	90.95	7.00e-118	416.00
IUUC-Cpo-022412	Cavia porcellus	80.17	1.00e-107	382.00
IUUC-Csa-023406	Chlorocebus sabaeus	96.98	8.00e-132	462.00
IUUC-Cho-024427	Choloepus hoffmanni	76.84	3.00e-75	273.00
IUUC-Dno-030085	Dasypus novemcinctus	92.24	3.00e-127	447.00
IUUC-Dor-030911	Dipodomys ordii	68.97	3.00e-76	278.00
IUUC-Ete-032469	Echinops telfairi	84.91	1.00e-117	415.00
IUUC-Eca-034352	Equus caballus	93.53	1.00e-128	451.00
IUUC-Eeu-034889	Erinaceus europaeus	77.59	4.00e-101	360.00
IUUC-Fca-036116	Felis catus	92.24	7.00e-120	422.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	96.05	1.00e-99	355.00
IUUC-Laf-053363	Loxodonta africana	91.45	3.00e-125	440.00
IUUC-Meu-056101	Macropus eugenii	77.73	6.00e-94	336.00
IUUC-Mdo-062046	Monodelphis domestica	75.11	2.00e-99	355.00
IUUC-Mmu-063184	Mus musculus	85.71	1.00e-58	218.00
IUUC-Mpu-065708	Mustela putorius furo	90.09	2.00e-124	437.00
IUUC-Mlu-067561	Myotis lucifugus	90.40	4.00e-94	336.00
IUUC-Nle-069665	Nomascus leucogenys	94.86	1.00e-118	418.00
IUUC-Opr-070301	Ochotona princeps	78.88	1.00e-104	372.00
IUUC-Ocu-074562	Oryctolagus cuniculus	92.86	2.00e-66	243.00
IUUC-Oga-088958	Otolemur garnettii	93.97	2.00e-129	454.00
IUUC-Oar-089541	Ovis aries	92.05	4.00e-96	343.00
IUUC-Ptr-090989	Pan troglodytes	99.57	2.00e-135	474.00
IUUC-Pan-092372	Papio anubis	96.12	6.00e-131	459.00
IUUC-Pab-098718	Pongo abelii	82.33	3.00e-105	374.00
IUUC-Pca-100453	Procavia capensis	90.09	2.00e-123	434.00
IUUC-Pva-102931	Pteropus vampyrus	93.10	2.00e-120	424.00
IUUC-Rno-105771	Rattus norvegicus	84.98	3.00e-99	354.00
IUUC-Sha-107557	Sarcophilus harrisii	74.68	7.00e-105	373.00
IUUC-Sar-113435	Sorex araneus	92.86	2.00e-66	243.00
IUUC-Ssc-116388	Sus scrofa	91.81	5.00e-127	446.00
IUUC-Tsy-119439	Tarsius syrichta	93.22	2.00e-97	347.00
IUUC-Tbe-127417	Tupaia belangeri	66.67	2.00e-69	254.00
IUUC-Ttr-129212	Tursiops truncatus	91.81	5.00e-127	446.00
IUUC-Vpa-130153	Vicugna pacos	91.38	2.00e-126	444.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence