iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054054

UUCD1 version

UUC-LoA-00582

Ensembl Protein ID

ENSLAFP00000014201.3

UniProt Accession

G3THW7; G3THW7_LOXAF

Protein Name

Uncharacterized protein

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000016940.3	ENSLAFT00000016938.3	ENSLAFP00000014201.3
ENSLAFG00000016940.3	ENSLAFT00000033724.1	ENSLAFP00000027706.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-60	199.1	626	659
UBD/Beta-Prp	3.30e-102	342.0	377	659

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 626  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 659
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 377  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 461
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 462  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 544
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 545  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 629
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 630  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 659
           *************************98776 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MNQELLSVGS KRRRTGSSLR GNPSSSQVDE DQMNRVVEEE QQQQQQQLRQ QEEEHTARNG 60
EVVGAEPRPG DQNDSQQGQL EENNNQFISV DEDSSGNQEE QEEDEEHGGE QDEEDEEEEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCAGG AACTGCTCTC TGTGGGCAGC AAAAGACGAC GAACTGGAAG CTCTCTGAGA 60
GGTAACCCTT CCTCAAGCCA GGTAGATGAG GACCAGATGA ATCGTGTGGT AGAAGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

KEGG

lav:100658423

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	97.18	0.00e+00	1221.00
IUUC-Apl-003489	Anas platyrhynchos	89.58	0.00e+00	1173.00
IUUC-Aca-005318	Anolis carolinensis	97.82	0.00e+00	1098.00
IUUC-Ago-007794	Ashbya gossypii	31.28	4.00e-62	232.00
IUUC-Acl-008123	Aspergillus clavatus	31.34	1.00e-74	274.00
IUUC-Afl-008730	Aspergillus flavus	31.59	6.00e-74	272.00
IUUC-Afu-009014	Aspergillus fumigatus	32.73	2.00e-75	276.00
IUUC-Ani-009332	Aspergillus nidulans	33.66	2.00e-80	293.00
IUUC-Ang-009790	Aspergillus niger	31.71	3.00e-75	276.00
IUUC-Aor-010215	Aspergillus oryzae	30.91	1.00e-74	274.00
IUUC-Ate-010535	Aspergillus terreus	32.28	3.00e-76	279.00
IUUC-Ame-010898	Astyanax mexicanus	93.98	0.00e+00	1045.00
IUUC-Bgr-012075	Blumeria graminis	33.40	1.00e-79	290.00
IUUC-Bta-012391	Bos taurus	98.55	0.00e+00	1110.00
IUUC-Bci-013725	Botrytis cinerea	33.40	1.00e-78	287.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	2.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	97.18	0.00e+00	1220.00
IUUC-Cfa-020237	Canis familiaris	97.19	0.00e+00	1222.00
IUUC-Cpo-022234	Cavia porcellus	98.55	0.00e+00	1111.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.54	8.00e-49	187.00
IUUC-Csa-023532	Chlorocebus sabaeus	97.18	0.00e+00	1195.00
IUUC-Cho-025026	Choloepus hoffmanni	83.80	0.00e+00	769.00
IUUC-Cin-025516	Ciona intestinalis	70.03	8.00e-141	493.00
IUUC-Csv-026312	Ciona savignyi	75.26	0.00e+00	753.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	5.00e-85	308.00
IUUC-Cne-027018	Cryptococcus neoformans	33.08	5.00e-73	269.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	5.00e-31	129.00
IUUC-Dre-028303	Danio rerio	93.90	0.00e+00	1046.00
IUUC-Dno-029576	Dasypus novemcinctus	95.49	0.00e+00	1201.00
IUUC-Dor-030196	Dipodomys ordii	92.11	0.00e+00	1202.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	2.00e-70	259.00
IUUC-Dme-031702	Drosophila melanogaster	76.81	0.00e+00	804.00
IUUC-Ete-032791	Echinops telfairi	90.74	0.00e+00	1002.00
IUUC-Eca-033424	Equus caballus	98.55	0.00e+00	1110.00
IUUC-Eeu-034996	Erinaceus europaeus	94.51	0.00e+00	1191.00
IUUC-Fca-036422	Felis catus	97.05	0.00e+00	1234.00
IUUC-Fal-037267	Ficedula albicollis	98.18	0.00e+00	1096.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	2.00e-84	306.00
IUUC-Fso-038258	Fusarium solani	34.21	2.00e-83	303.00
IUUC-Gmo-039119	Gadus morhua	83.55	0.00e+00	900.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.66	3.00e-85	309.00
IUUC-Gga-040667	Gallus gallus	89.44	0.00e+00	1172.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.63	0.00e+00	801.00
IUUC-Ggo-044422	Gorilla gorilla	97.18	0.00e+00	1197.00
IUUC-Hsa-045898	Homo sapiens	97.04	0.00e+00	1196.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.57	0.00e+00	976.00
IUUC-Kpa-049097	Komagataella pastoris	32.06	2.00e-76	280.00
IUUC-Lch-050414	Latimeria chalumnae	95.87	0.00e+00	1085.00
IUUC-Loc-052348	Lepisosteus oculatus	95.83	0.00e+00	1071.00
IUUC-Lma-053185	Leptosphaeria maculans	32.40	4.00e-72	266.00
IUUC-Mcc-055056	Macaca mulatta	97.18	0.00e+00	1195.00
IUUC-Meu-056778	Macropus eugenii	91.81	0.00e+00	732.00
IUUC-Mor-057133	Magnaporthe oryzae	38.87	1.00e-73	271.00
IUUC-Mpo-057542	Magnaporthe poae	38.87	8.00e-74	272.00
IUUC-Mla-059081	Melampsora laricipopulina	32.57	1.00e-75	277.00
IUUC-Mga-059255	Meleagris gallopavo	89.72	0.00e+00	1162.00
IUUC-Mvi-060490	Microbotryum violaceum	39.00	1.00e-67	251.00
IUUC-Mmr-061292	Microcebus murinus	97.18	0.00e+00	1225.00
IUUC-Mdo-062304	Monodelphis domestica	94.13	0.00e+00	1207.00
IUUC-Mmu-063610	Mus musculus	93.55	0.00e+00	1245.00
IUUC-Mpu-065931	Mustela putorius furo	96.90	0.00e+00	1223.00
IUUC-Mlu-066976	Myotis lucifugus	96.62	0.00e+00	1241.00
IUUC-Nfi-068428	Neosartorya fischeri	32.13	2.00e-75	276.00
IUUC-Ncr-068688	Neurospora crassa	35.97	2.00e-87	316.00
IUUC-Nle-070174	Nomascus leucogenys	96.90	0.00e+00	1195.00
IUUC-Opr-070851	Ochotona princeps	86.32	0.00e+00	652.00
IUUC-Ont-071997	Oreochromis niloticus	93.10	0.00e+00	1069.00
IUUC-Oan-072936	Ornithorhynchus anatinus	93.39	0.00e+00	1232.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.64	0.00e+00	1137.00
IUUC-Obr-076806	Oryza brachyantha	31.52	9.00e-30	126.00
IUUC-Oin-079809	Oryza indica	31.52	7.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	93.90	0.00e+00	1058.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	4.00e-38	150.00
IUUC-Oga-088884	Otolemur garnettii	99.74	0.00e+00	786.00
IUUC-Oar-090220	Ovis aries	94.96	0.00e+00	1190.00
IUUC-Ptr-090492	Pan troglodytes	97.04	0.00e+00	1196.00
IUUC-Pan-091770	Papio anubis	97.18	0.00e+00	1195.00
IUUC-Psi-093207	Pelodiscus sinensis	98.55	0.00e+00	1110.00
IUUC-Pma-094749	Petromyzon marinus	83.85	0.00e+00	945.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.56	1.00e-70	261.00
IUUC-Pfo-096493	Poecilia formosa	94.19	0.00e+00	1058.00
IUUC-Pab-098141	Pongo abelii	98.55	0.00e+00	1110.00
IUUC-Pca-100571	Procavia capensis	98.79	0.00e+00	853.00
IUUC-Pva-102988	Pteropus vampyrus	97.04	0.00e+00	1227.00
IUUC-Pgr-103612	Puccinia graminis	35.66	2.00e-62	233.00
IUUC-Ptt-103698	Puccinia triticina	35.55	1.00e-41	164.00
IUUC-Pte-104275	Pyrenophora teres	32.36	1.00e-73	271.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	39.09	7.00e-70	258.00
IUUC-Rno-105706	Rattus norvegicus	98.25	0.00e+00	1141.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.39	8.00e-61	228.00
IUUC-Sha-107653	Sarcophilus harrisii	95.92	0.00e+00	1243.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.64	7.00e-79	288.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.35	4.00e-63	235.00
IUUC-Sar-113600	Sorex araneus	91.97	0.00e+00	1115.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	1.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	95.35	0.00e+00	1192.00
IUUC-Tgu-117510	Taeniopygia guttata	89.86	0.00e+00	1167.00
IUUC-Tru-117819	Takifugu rubripes	93.78	0.00e+00	1080.00
IUUC-Tsy-118828	Tarsius syrichta	97.32	0.00e+00	1234.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.47	0.00e+00	1070.00
IUUC-Tre-122193	Trichoderma reesei	36.25	3.00e-85	309.00
IUUC-Tvi-122615	Trichoderma virens	35.03	8.00e-84	304.00
IUUC-Tme-127021	Tuber melanosporum	34.55	9.00e-84	304.00
IUUC-Tbe-127925	Tupaia belangeri	99.81	0.00e+00	1102.00
IUUC-Ttr-128899	Tursiops truncatus	97.04	0.00e+00	1220.00
IUUC-Uma-129449	Ustilago maydis	46.89	8.00e-67	249.00
IUUC-Vda-129802	Verticillium dahliae	36.20	6.00e-88	318.00
IUUC-Vpa-130082	Vicugna pacos	95.97	0.00e+00	1042.00
IUUC-Xtr-132213	Xenopus tropicalis	86.99	0.00e+00	1146.00
IUUC-Xma-133646	Xiphophorus maculatus	94.53	0.00e+00	1050.00
IUUC-Yli-134429	Yarrowia lipolytica	34.27	1.00e-86	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence