iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117479

Ensembl Protein ID

ENSTGUP00000008899.1

UniProt Accession

B5FZR7; B5FZR7_TAEGU

Genbank Protein ID

ACH44528.1; ACH44529.1; ACH44530.1; ACH44532.1; ACH44533.1

Protein Name

Putative growth factor receptor-bound protein 2

Genbank Nucleotide ID

ABQF01044854; DQ214655; DQ214656; DQ214658; DQ214660

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000008612.1	ENSTGUT00000008995.1	ENSTGUP00000008899.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-36	124.2	157	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+++eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEEGELGFHRGDFIQVL--DNSDPNWWKG--ACRGQTGMFPRNYVTPVN 214
           5689**************************..9*********..8**************997 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MEAIAKYDFR ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGCCA TCGCCAAGTA CGACTTCAGA GCCACCGCGG ATGACGAGCT GAGCTTCAAA 60
CGGGGGGATA TCCTTAAGGT AAGTGGTGGG CTCGGGAGTT CCCTCTTTAC CGCTGGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0675--Receptor
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

KEGG

tgu:100190285

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	95.83	2.00e-110	390.00
IUUC-Apl-003322	Anas platyrhynchos	98.95	2.00e-112	397.00
IUUC-Aca-005193	Anolis carolinensis	98.16	2.00e-127	447.00
IUUC-Ame-010929	Astyanax mexicanus	91.71	3.00e-120	423.00
IUUC-Bta-012932	Bos taurus	96.31	2.00e-125	441.00
IUUC-Cel-018665	Caenorhabditis elegans	58.06	2.00e-71	261.00
IUUC-Cja-019225	Callithrix jacchus	96.31	2.00e-125	441.00
IUUC-Cfa-020887	Canis familiaris	96.31	2.00e-125	441.00
IUUC-Cpo-022488	Cavia porcellus	96.31	2.00e-125	441.00
IUUC-Csa-023326	Chlorocebus sabaeus	96.31	2.00e-125	441.00
IUUC-Cho-024953	Choloepus hoffmanni	78.34	6.00e-94	335.00
IUUC-Cin-025144	Ciona intestinalis	62.74	1.00e-73	268.00
IUUC-Csv-026210	Ciona savignyi	60.66	1.00e-71	261.00
IUUC-Dre-028403	Danio rerio	94.01	8.00e-123	431.00
IUUC-Dno-029187	Dasypus novemcinctus	94.93	2.00e-124	437.00
IUUC-Dor-030763	Dipodomys ordii	96.31	2.00e-125	441.00
IUUC-Dme-031741	Drosophila melanogaster	64.62	2.00e-77	281.00
IUUC-Ete-032354	Echinops telfairi	67.13	5.00e-79	286.00
IUUC-Eca-033222	Equus caballus	96.31	2.00e-125	441.00
IUUC-Eeu-034513	Erinaceus europaeus	70.05	4.00e-84	303.00
IUUC-Fca-036294	Felis catus	96.31	2.00e-125	441.00
IUUC-Fal-037130	Ficedula albicollis	99.54	4.00e-129	452.00
IUUC-Gmo-039546	Gadus morhua	93.55	4.00e-122	429.00
IUUC-Gga-041139	Gallus gallus	98.62	1.00e-127	447.00
IUUC-Gac-041968	Gasterosteus aculeatus	94.93	2.00e-123	433.00
IUUC-Ggo-044562	Gorilla gorilla	96.31	2.00e-125	441.00
IUUC-Hsa-046730	Homo sapiens	96.31	2.00e-125	441.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	96.31	2.00e-125	441.00
IUUC-Lch-050230	Latimeria chalumnae	96.27	3.00e-74	271.00
IUUC-Loc-052723	Lepisosteus oculatus	94.93	6.00e-124	435.00
IUUC-Laf-053774	Loxodonta africana	94.93	2.00e-124	437.00
IUUC-Mcc-054603	Macaca mulatta	96.31	2.00e-125	441.00
IUUC-Meu-056173	Macropus eugenii	80.65	2.00e-99	353.00
IUUC-Mga-059950	Meleagris gallopavo	98.62	1.00e-127	447.00
IUUC-Mmr-060878	Microcebus murinus	96.31	2.00e-125	441.00
IUUC-Mdo-062454	Monodelphis domestica	97.70	1.00e-126	444.00
IUUC-Mmu-063913	Mus musculus	95.85	4.00e-125	439.00
IUUC-Mpu-066125	Mustela putorius furo	96.31	2.00e-125	441.00
IUUC-Mlu-068007	Myotis lucifugus	96.31	2.00e-125	441.00
IUUC-Nle-069101	Nomascus leucogenys	96.31	2.00e-125	441.00
IUUC-Opr-071075	Ochotona princeps	96.31	2.00e-125	441.00
IUUC-Ont-072253	Oreochromis niloticus	91.24	2.00e-119	420.00
IUUC-Ocu-074583	Oryctolagus cuniculus	96.31	2.00e-125	441.00
IUUC-Ola-086586	Oryzias latipes	94.87	7.00e-86	310.00
IUUC-Oga-089047	Otolemur garnettii	96.31	2.00e-125	441.00
IUUC-Oar-089904	Ovis aries	89.45	5.00e-115	405.00
IUUC-Ptr-090678	Pan troglodytes	96.31	2.00e-125	441.00
IUUC-Pan-092090	Papio anubis	96.31	2.00e-125	441.00
IUUC-Psi-093765	Pelodiscus sinensis	98.16	5.00e-127	445.00
IUUC-Pma-094650	Petromyzon marinus	83.87	2.00e-109	387.00
IUUC-Pfo-096131	Poecilia formosa	94.01	5.00e-123	432.00
IUUC-Pab-098709	Pongo abelii	96.31	2.00e-125	441.00
IUUC-Pca-100581	Procavia capensis	95.29	1.00e-109	387.00
IUUC-Pva-103066	Pteropus vampyrus	96.31	2.00e-125	441.00
IUUC-Rno-105224	Rattus norvegicus	96.31	2.00e-125	441.00
IUUC-Sce-106302	Saccharomyces cerevisiae	53.70	2.00e-15	75.50
IUUC-Sha-107247	Sarcophilus harrisii	98.43	7.00e-112	395.00
IUUC-Sar-113277	Sorex araneus	80.65	1.00e-99	354.00
IUUC-Ssc-115478	Sus scrofa	96.31	2.00e-125	441.00
IUUC-Tru-118451	Takifugu rubripes	85.15	2.00e-107	380.00
IUUC-Tsy-119029	Tarsius syrichta	92.50	6.00e-83	298.00
IUUC-Tni-120563	Tetraodon nigroviridis	51.17	1.00e-62	231.00
IUUC-Tbe-128097	Tupaia belangeri	95.85	2.00e-124	437.00
IUUC-Ttr-128871	Tursiops truncatus	98.72	1.00e-89	320.00
IUUC-Vpa-130754	Vicugna pacos	96.31	2.00e-125	441.00
IUUC-Xtr-132275	Xenopus tropicalis	91.27	4.00e-123	432.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence