iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC
mRNA Expression
ArrayExpress	THPA
DNA & RNA Element
TargetScan
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-24	84.5	803	840

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ +tc+++ + ++lvsG++D+++kvWD++tg++lk+
   Q: 803  GHQGTITCMDL-CkNRLVSGGRDCQVKVWDVDTGKCLKT 840
           8**********.4489********************986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK LGRETEEQDS 60
DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCAAGGGAC AGAAGAAAGA CAGCCTAGGA GCAGAGCCTC CCAGATGGCT GAGTTGGATC 60
TAATGGCTCC AGGGCCACTG CCCAGGGCCA CTGCTCAGCC CCCAGCCCCT CTCAGCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR013320--ConA-like_dom
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR006574--PRY
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000315--Znf_B-box
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50119--ZF_BBOX

Pfam

PF13765--PRY
PF00400--WD40
PF00643--zf-B_box

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00336--BBOX
SM00589--PRY
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001837	Ailuropoda melanoleuca	74.79	0.00e+00	1275.00
IUUC-Bta-012667	Bos taurus	70.86	0.00e+00	1266.00
IUUC-Cpo-021429	Cavia porcellus	73.23	0.00e+00	1311.00
IUUC-Ete-032823	Echinops telfairi	77.84	2.00e-90	327.00
IUUC-Ggo-044603	Gorilla gorilla	78.37	0.00e+00	1151.00
IUUC-Mlu-067552	Myotis lucifugus	70.91	0.00e+00	1249.00
IUUC-Opr-070455	Ochotona princeps	71.87	0.00e+00	973.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence