iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011856

Ensembl Protein ID

ENSAMXP00000016283.1

UniProt Accession

W5L8X1; W5L8X1_ASTMX

Genbank Protein ID

ENSAMXP00000016283

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

APWO01083407

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000015822.1	ENSAMXT00000016283.1	ENSAMXP00000016283.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.40e-19	70.1	1	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++v++++++ f++ev+   +v+elKe++ + +gv+p+q+++I+aG++L+ d+tL+ +++ ++s+vh+v+
   Q: 1    MIVFVRFNSSHGFPVEVETGASVAELKEAVGRLQGVQPDQLRVIFAGRELSSDSTLQGCDLPEQSTVHVVL 71
           89*****99999*********************************************************96 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

MIVFVRFNSS HGFPVEVETG ASVAELKEAV GRLQGVQPDQ LRVIFAGREL SSDSTLQGCD 60
LPEQSTVHVV LPPAGSARHS ELVLQQRLGR GVNSLTRLDL SASRLHATST GLAVILETDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCGGTA AGTCATAACT GAAATTCAGC GCGTTTGTGT TTTGTGAGCG CGGTCGGCTG 60
TGTGTCCCGC GCGCTGGAGT TTTATAAAGC TGTGTTTGTG TTGTGTTTGT AGCACAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0051865--P:protein autoubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	58.89	5.00e-93	333.00
IUUC-Apl-003304	Anas platyrhynchos	71.56	6.00e-147	513.00
IUUC-Aca-004908	Anolis carolinensis	63.55	8.00e-41	158.00
IUUC-Bta-013014	Bos taurus	63.53	6.00e-144	503.00
IUUC-Cel-018687	Caenorhabditis elegans	29.13	1.00e-45	176.00
IUUC-Cja-019274	Callithrix jacchus	58.89	2.00e-91	328.00
IUUC-Cfa-020461	Canis familiaris	57.29	1.00e-91	329.00
IUUC-Cpo-022251	Cavia porcellus	59.25	3.00e-92	331.00
IUUC-Csa-023112	Chlorocebus sabaeus	59.38	3.00e-88	317.00
IUUC-Cho-024504	Choloepus hoffmanni	47.08	4.00e-103	368.00
IUUC-Dre-028202	Danio rerio	80.96	0.00e+00	736.00
IUUC-Dno-028946	Dasypus novemcinctus	58.49	6.00e-33	131.00
IUUC-Dor-030508	Dipodomys ordii	55.43	2.00e-101	362.00
IUUC-Dme-031980	Drosophila melanogaster	44.66	5.00e-113	401.00
IUUC-Ete-032281	Echinops telfairi	50.52	9.00e-62	230.00
IUUC-Eca-033228	Equus caballus	58.82	1.00e-92	332.00
IUUC-Fal-037507	Ficedula albicollis	65.94	0.00e+00	631.00
IUUC-Gmo-038744	Gadus morhua	63.41	3.00e-100	358.00
IUUC-Gga-040353	Gallus gallus	66.02	0.00e+00	634.00
IUUC-Gac-042519	Gasterosteus aculeatus	56.81	2.00e-151	528.00
IUUC-Hsa-046016	Homo sapiens	63.58	2.00e-167	582.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	61.24	8.00e-156	543.00
IUUC-Loc-052389	Lepisosteus oculatus	70.54	0.00e+00	644.00
IUUC-Mcc-054933	Macaca mulatta	63.36	4.00e-168	584.00
IUUC-Meu-055963	Macropus eugenii	52.33	2.00e-108	385.00
IUUC-Mpo-057509	Magnaporthe poae	39.71	1.00e-10	60.10
IUUC-Mga-059626	Meleagris gallopavo	76.00	5.00e-30	121.00
IUUC-Mmr-061566	Microcebus murinus	70.32	6.00e-78	283.00
IUUC-Mdo-061952	Monodelphis domestica	71.93	1.00e-24	103.00
IUUC-Mmu-063561	Mus musculus	63.07	2.00e-174	605.00
IUUC-Mpu-065799	Mustela putorius furo	60.42	2.00e-93	335.00
IUUC-Mlu-068134	Myotis lucifugus	59.33	5.00e-114	404.00
IUUC-Nle-070078	Nomascus leucogenys	58.19	9.00e-95	339.00
IUUC-Opr-070541	Ochotona princeps	62.47	2.00e-157	548.00
IUUC-Ont-071743	Oreochromis niloticus	63.89	2.00e-160	558.00
IUUC-Oan-073700	Ornithorhynchus anatinus	68.52	2.00e-17	79.70
IUUC-Ola-086426	Oryzias latipes	68.57	6.00e-69	252.00
IUUC-Oga-088867	Otolemur garnettii	62.55	4.00e-164	571.00
IUUC-Oar-089365	Ovis aries	60.44	8.00e-123	433.00
IUUC-Ptr-091371	Pan troglodytes	63.58	5.00e-167	580.00
IUUC-Pan-092443	Papio anubis	59.03	2.00e-91	328.00
IUUC-Psi-093851	Pelodiscus sinensis	58.90	4.00e-77	280.00
IUUC-Pfo-097194	Poecilia formosa	58.70	9.00e-148	516.00
IUUC-Pab-097999	Pongo abelii	51.29	4.00e-90	324.00
IUUC-Pca-100410	Procavia capensis	62.44	1.00e-141	496.00
IUUC-Pva-102300	Pteropus vampyrus	56.52	2.00e-142	498.00
IUUC-Rno-105556	Rattus norvegicus	59.17	5.00e-92	330.00
IUUC-Sha-106992	Sarcophilus harrisii	66.67	4.00e-17	79.00
IUUC-Sar-113121	Sorex araneus	79.31	8.00e-52	197.00
IUUC-Ssc-116435	Sus scrofa	59.58	8.00e-96	343.00
IUUC-Tgu-117489	Taeniopygia guttata	65.80	0.00e+00	632.00
IUUC-Tru-117927	Takifugu rubripes	60.16	1.00e-166	579.00
IUUC-Tsy-119372	Tarsius syrichta	69.57	2.00e-132	466.00
IUUC-Tni-120043	Tetraodon nigroviridis	60.04	4.00e-148	517.00
IUUC-Tbe-127539	Tupaia belangeri	56.06	5.00e-137	481.00
IUUC-Ttr-129149	Tursiops truncatus	59.91	6.00e-166	577.00
IUUC-Vpa-130439	Vicugna pacos	46.87	6.00e-113	400.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence