iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054587

UUCD1 version

UUC-LoA-00424

Ensembl Protein ID

ENSLAFP00000010418.4

UniProt Accession

G3T9G2; G3T9G2_LOXAF

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012468.4	ENSLAFT00000012467.4	ENSLAFP00000010418.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-44	148.0	145	180
UBD/Beta-Prp	4.10e-60	203.8	15	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+ +k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHMVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKGSGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           6778888999989999************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D +v+lWdl  gk++ ++tg ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHMVKLWDLTAGKMMSEFTG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+s+ f p++  l+sg +D s+r++ 
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSILFNPDGCCLYSGCQD-SLRVYG 258
           ***********************************************************766.556543 PP

Organism

Loxodonta africana

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK GSGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACCC CTGTGGTCAC CAAGACAGCC TGGAAGCTGC GTGAGTGGTT TCCTTTTTTC 60
TTTTTCACCC CATTTACCCT TTGATCCATT TGTTGCTGGG TCACCTGAAC CCACTGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.17	4.00e-86	313.00
IUUC-Aml-002187	Ailuropoda melanoleuca	89.51	0.00e+00	1117.00
IUUC-Atr-002899	Amborella trichopoda	50.61	5.00e-103	369.00
IUUC-Apl-003305	Anas platyrhynchos	77.84	0.00e+00	1018.00
IUUC-Aca-004635	Anolis carolinensis	80.49	0.00e+00	972.00
IUUC-Aly-005711	Arabidopsis lyrata	51.50	5.00e-102	365.00
IUUC-Ath-007606	Arabidopsis thaliana	51.50	4.00e-102	365.00
IUUC-Ame-010870	Astyanax mexicanus	55.66	9.00e-99	353.00
IUUC-Bta-012527	Bos taurus	95.17	0.00e+00	1193.00
IUUC-Bdi-014652	Brachypodium distachyon	53.51	3.00e-104	373.00
IUUC-Bol-015242	Brassica oleracea	50.50	3.00e-100	359.00
IUUC-Bra-017390	Brassica rapa	50.83	1.00e-100	360.00
IUUC-Cja-019706	Callithrix jacchus	95.15	0.00e+00	1105.00
IUUC-Cfa-020139	Canis familiaris	79.61	0.00e+00	763.00
IUUC-Cpo-021710	Cavia porcellus	95.14	0.00e+00	1183.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.81	1.00e-68	254.00
IUUC-Csa-023546	Chlorocebus sabaeus	96.66	0.00e+00	1065.00
IUUC-Cin-025156	Ciona intestinalis	42.26	7.00e-158	550.00
IUUC-Csv-025962	Ciona savignyi	49.32	7.00e-89	320.00
IUUC-Dre-028215	Danio rerio	61.95	0.00e+00	855.00
IUUC-Dno-029314	Dasypus novemcinctus	94.53	0.00e+00	1127.00
IUUC-Dor-030482	Dipodomys ordii	95.14	0.00e+00	1217.00
IUUC-Dme-032188	Drosophila melanogaster	40.13	9.00e-60	225.00
IUUC-Eca-034143	Equus caballus	94.53	0.00e+00	1188.00
IUUC-Fca-035924	Felis catus	95.59	0.00e+00	1162.00
IUUC-Fal-037387	Ficedula albicollis	78.88	0.00e+00	1004.00
IUUC-Gmo-038692	Gadus morhua	64.55	2.00e-155	542.00
IUUC-Gga-040597	Gallus gallus	79.18	0.00e+00	1048.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.09	0.00e+00	821.00
IUUC-Gma-044134	Glycine max	32.11	2.00e-108	386.00
IUUC-Ggo-044761	Gorilla gorilla	96.81	0.00e+00	1102.00
IUUC-Hsa-045698	Homo sapiens	96.50	0.00e+00	1132.00
IUUC-Hvu-047649	Hordeum vulgare	53.25	3.00e-104	372.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	94.53	0.00e+00	1154.00
IUUC-Lch-049674	Latimeria chalumnae	67.84	0.00e+00	923.00
IUUC-Lpe-051554	Leersia perrieri	54.52	1.00e-106	380.00
IUUC-Loc-052623	Lepisosteus oculatus	67.24	0.00e+00	914.00
IUUC-Mcc-055851	Macaca mulatta	96.66	0.00e+00	1102.00
IUUC-Meu-056704	Macropus eugenii	90.73	0.00e+00	1193.00
IUUC-Mtr-058053	Medicago truncatula	52.16	3.00e-104	372.00
IUUC-Mga-059608	Meleagris gallopavo	78.69	0.00e+00	1038.00
IUUC-Mmr-061154	Microcebus murinus	94.39	0.00e+00	1139.00
IUUC-Mdo-062365	Monodelphis domestica	87.12	0.00e+00	1126.00
IUUC-Mmu-063754	Mus musculus	94.38	0.00e+00	1158.00
IUUC-Mac-064667	Musa acuminata	52.56	3.00e-101	361.00
IUUC-Mpu-066245	Mustela putorius furo	95.44	0.00e+00	1126.00
IUUC-Mlu-067692	Myotis lucifugus	96.01	0.00e+00	1155.00
IUUC-Nle-070051	Nomascus leucogenys	94.23	0.00e+00	1090.00
IUUC-Opr-070855	Ochotona princeps	95.44	0.00e+00	1182.00
IUUC-Ont-071883	Oreochromis niloticus	58.59	0.00e+00	820.00
IUUC-Oan-073293	Ornithorhynchus anatinus	89.76	0.00e+00	1038.00
IUUC-Ocu-074644	Oryctolagus cuniculus	96.35	0.00e+00	1196.00
IUUC-Oba-075448	Oryza barthii	54.85	5.00e-107	382.00
IUUC-Obr-076385	Oryza brachyantha	53.85	7.00e-106	378.00
IUUC-Ogl-077427	Oryza glaberrima	54.85	2.00e-107	383.00
IUUC-Ogu-079022	Oryza glumaepatula	48.88	7.00e-98	352.00
IUUC-Oin-079811	Oryza indica	52.41	4.00e-104	372.00
IUUC-Olo-080245	Oryza longistaminata	52.41	5.00e-104	372.00
IUUC-Ome-081239	Oryza meridionalis	54.27	1.00e-103	370.00
IUUC-Oni-082640	Oryza nivara	54.85	5.00e-107	382.00
IUUC-Opu-083748	Oryza punctata	51.22	8.00e-107	381.00
IUUC-Oru-084609	Oryza rufipogon	54.85	5.00e-107	382.00
IUUC-Osa-086267	Oryza sativa	48.88	4.00e-98	352.00
IUUC-Ola-087483	Oryzias latipes	55.29	0.00e+00	635.00
IUUC-Oga-087964	Otolemur garnettii	95.29	0.00e+00	1193.00
IUUC-Oar-089483	Ovis aries	93.97	0.00e+00	1159.00
IUUC-Ptr-091387	Pan troglodytes	96.66	0.00e+00	1134.00
IUUC-Pan-092623	Papio anubis	96.66	0.00e+00	1102.00
IUUC-Psi-093830	Pelodiscus sinensis	82.00	0.00e+00	1055.00
IUUC-Pma-094135	Petromyzon marinus	46.31	2.00e-40	158.00
IUUC-Ppa-095379	Physcomitrella patens	50.46	3.00e-98	352.00
IUUC-Pfo-096755	Poecilia formosa	57.60	0.00e+00	798.00
IUUC-Pab-097564	Pongo abelii	95.56	0.00e+00	971.00
IUUC-Pop-099149	Populus trichocarpa	52.16	1.00e-103	370.00
IUUC-Pca-100357	Procavia capensis	99.05	2.00e-125	442.00
IUUC-Ppe-101237	Prunus persica	52.16	2.00e-103	370.00
IUUC-Pva-102397	Pteropus vampyrus	91.79	0.00e+00	1084.00
IUUC-Rno-105349	Rattus norvegicus	94.53	0.00e+00	1200.00
IUUC-Smo-109409	Selaginella moellendorffii	54.27	6.00e-102	365.00
IUUC-Sit-110360	Setaria italica	54.52	6.00e-106	378.00
IUUC-Sly-111307	Solanum lycopersicum	52.49	5.00e-99	355.00
IUUC-Stu-112462	Solanum tuberosum	52.05	2.00e-95	342.00
IUUC-Sar-112953	Sorex araneus	81.14	6.00e-108	384.00
IUUC-Sbi-114389	Sorghum bicolor	46.98	6.00e-95	342.00
IUUC-Ssc-115949	Sus scrofa	93.47	0.00e+00	887.00
IUUC-Tgu-117461	Taeniopygia guttata	78.11	0.00e+00	1032.00
IUUC-Tru-117865	Takifugu rubripes	59.00	0.00e+00	790.00
IUUC-Tsy-119036	Tarsius syrichta	82.26	5.00e-85	308.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.60	0.00e+00	779.00
IUUC-Tca-121185	Theobroma cacao	51.50	9.00e-102	365.00
IUUC-Tae-125263	Triticum aestivum	53.57	1.00e-104	374.00
IUUC-Tur-126181	Triticum urartu	47.96	6.00e-95	342.00
IUUC-Tbe-127518	Tupaia belangeri	81.33	0.00e+00	643.00
IUUC-Ttr-128172	Tursiops truncatus	94.83	0.00e+00	1140.00
IUUC-Vvi-131489	Vitis vinifera	52.82	4.00e-104	372.00
IUUC-Xtr-132915	Xenopus tropicalis	72.88	0.00e+00	961.00
IUUC-Xma-134133	Xiphophorus maculatus	57.18	0.00e+00	786.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence