iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033325

Ensembl Protein ID

ENSECAP00000020913.1

UniProt Accession

F6USJ9; F6USJ9_HORSE

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000023256.1	ENSECAT00000025147.1	ENSECAP00000020913.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-19	68.0	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l+ ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHRYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH RYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGTA GCTGCAGCTC AAACCCCGAA GATGACTGGA TGGAAAACAT CGATGTATGT 60
GAGAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGGTAAG AGGCAAGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0005102--F:receptor binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050853--P:B cell receptor signaling pathway
GO:0016477--P:cell migration
GO:0006882--P:cellular zinc ion homeostasis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042981--P:regulation of apoptotic process
GO:0042127--P:regulation of cell proliferation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	90.56	0.00e+00	994.00
IUUC-Apl-004134	Anas platyrhynchos	77.85	0.00e+00	703.00
IUUC-Bta-013264	Bos taurus	95.10	0.00e+00	1005.00
IUUC-Cja-019574	Callithrix jacchus	94.54	0.00e+00	709.00
IUUC-Cfa-021161	Canis familiaris	90.37	0.00e+00	994.00
IUUC-Cpo-022492	Cavia porcellus	93.73	0.00e+00	981.00
IUUC-Csa-023270	Chlorocebus sabaeus	76.11	0.00e+00	764.00
IUUC-Dre-028005	Danio rerio	72.61	0.00e+00	685.00
IUUC-Dno-029365	Dasypus novemcinctus	91.57	0.00e+00	952.00
IUUC-Dor-030892	Dipodomys ordii	89.46	0.00e+00	913.00
IUUC-Eeu-035004	Erinaceus europaeus	86.20	0.00e+00	772.00
IUUC-Fca-035908	Felis catus	96.27	0.00e+00	1013.00
IUUC-Fal-036804	Ficedula albicollis	71.48	0.00e+00	734.00
IUUC-Gmo-038984	Gadus morhua	63.30	0.00e+00	677.00
IUUC-Gga-040997	Gallus gallus	80.00	0.00e+00	864.00
IUUC-Gac-041854	Gasterosteus aculeatus	67.32	0.00e+00	705.00
IUUC-Gma-043628	Glycine max	32.34	8.00e-21	95.90
IUUC-Ggo-045238	Gorilla gorilla	90.19	0.00e+00	989.00
IUUC-Hsa-047039	Homo sapiens	95.49	0.00e+00	1004.00
IUUC-Hvu-047815	Hordeum vulgare	28.86	9.00e-21	95.50
IUUC-Itr-048479	Ictidomys tridecemlineatus	95.49	0.00e+00	1006.00
IUUC-Lch-049568	Latimeria chalumnae	75.83	0.00e+00	817.00
IUUC-Loc-052222	Lepisosteus oculatus	65.50	0.00e+00	642.00
IUUC-Laf-054499	Loxodonta africana	89.63	0.00e+00	984.00
IUUC-Mcc-054872	Macaca mulatta	74.82	0.00e+00	811.00
IUUC-Meu-056879	Macropus eugenii	89.88	0.00e+00	954.00
IUUC-Mtr-058765	Medicago truncatula	33.17	2.00e-20	94.40
IUUC-Mga-059971	Meleagris gallopavo	79.41	0.00e+00	854.00
IUUC-Mmr-060740	Microcebus murinus	95.29	0.00e+00	1003.00
IUUC-Mdo-062192	Monodelphis domestica	91.37	0.00e+00	970.00
IUUC-Mmu-064241	Mus musculus	93.92	0.00e+00	994.00
IUUC-Mpu-066595	Mustela putorius furo	95.10	0.00e+00	1002.00
IUUC-Mlu-067069	Myotis lucifugus	93.74	0.00e+00	988.00
IUUC-Opr-070472	Ochotona princeps	89.72	0.00e+00	976.00
IUUC-Ont-071711	Oreochromis niloticus	66.93	0.00e+00	676.00
IUUC-Ocu-074221	Oryctolagus cuniculus	94.52	0.00e+00	994.00
IUUC-Ola-087000	Oryzias latipes	67.39	0.00e+00	703.00
IUUC-Oga-088225	Otolemur garnettii	94.90	0.00e+00	999.00
IUUC-Oar-090244	Ovis aries	84.62	0.00e+00	955.00
IUUC-Ptr-090751	Pan troglodytes	98.57	0.00e+00	723.00
IUUC-Pan-091804	Papio anubis	94.90	0.00e+00	996.00
IUUC-Psi-093252	Pelodiscus sinensis	75.24	0.00e+00	796.00
IUUC-Pfo-096542	Poecilia formosa	66.41	0.00e+00	703.00
IUUC-Pab-098168	Pongo abelii	94.88	0.00e+00	951.00
IUUC-Pca-100547	Procavia capensis	92.24	4.00e-176	610.00
IUUC-Rno-105542	Rattus norvegicus	93.73	0.00e+00	993.00
IUUC-Sha-107524	Sarcophilus harrisii	90.59	0.00e+00	966.00
IUUC-Sar-113235	Sorex araneus	87.29	0.00e+00	832.00
IUUC-Sbi-114267	Sorghum bicolor	30.04	1.00e-21	98.20
IUUC-Ssc-115624	Sus scrofa	95.49	0.00e+00	1009.00
IUUC-Tru-118559	Takifugu rubripes	65.76	0.00e+00	696.00
IUUC-Tca-121341	Theobroma cacao	33.08	5.00e-22	99.80
IUUC-Ttr-129002	Tursiops truncatus	86.30	0.00e+00	933.00
IUUC-Xtr-132224	Xenopus tropicalis	74.12	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence