iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069070

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01021306

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000008123.2	ENSNLET00000010553.2	ENSNLEP00000010055.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-128	429.2	637	969

Active Site

Position(s)	Description	Evidence
939	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtre.flallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++ lk+rl++ef+ E+gld+gG   e ++  + k+ +np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld
   Q: 637  PDVLKARLWIEFESEKGLDYGGCGPEkWFLTVQKRCFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLD 725
           57899*****************976559999********************************************************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
            ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv+
   Q: 726  GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVI 809
           ************************************99...6666..7***************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqF
   Q: 810  QWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF 898
           ***************************************************************************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           vTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 899  VTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 969
           **********************************************************************8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCCCGCAG CCTTCCGGGA GGAAGCGGCG CCGGCAGCGG CCAGGGCGCG CTCTCGGGCA 60
CCCTCACCTG CCGGCGCCCG GCCGCTTCCC CGGCAGGGCG TGCGCAGGGT AGGGTGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	91.83	0.00e+00	1606.00
IUUC-Apl-003893	Anas platyrhynchos	90.66	0.00e+00	1625.00
IUUC-Aca-004744	Anolis carolinensis	87.81	0.00e+00	1587.00
IUUC-Acl-008273	Aspergillus clavatus	48.18	3.00e-158	552.00
IUUC-Ang-009738	Aspergillus niger	48.25	1.00e-156	546.00
IUUC-Aor-010053	Aspergillus oryzae	57.91	9.00e-101	359.00
IUUC-Ate-010529	Aspergillus terreus	48.35	8.00e-159	554.00
IUUC-Ame-010810	Astyanax mexicanus	68.80	0.00e+00	1184.00
IUUC-Bta-012679	Bos taurus	93.74	0.00e+00	1511.00
IUUC-Cja-018732	Callithrix jacchus	95.40	0.00e+00	1762.00
IUUC-Cfa-021226	Canis familiaris	93.76	0.00e+00	1705.00
IUUC-Cpo-021671	Cavia porcellus	92.51	0.00e+00	1662.00
IUUC-Csa-023344	Chlorocebus sabaeus	93.96	0.00e+00	1748.00
IUUC-Cho-024832	Choloepus hoffmanni	97.17	0.00e+00	720.00
IUUC-Dre-027770	Danio rerio	75.76	0.00e+00	1385.00
IUUC-Dno-029466	Dasypus novemcinctus	94.36	0.00e+00	1751.00
IUUC-Dor-030138	Dipodomys ordii	88.45	0.00e+00	1547.00
IUUC-Ete-033145	Echinops telfairi	87.72	0.00e+00	1266.00
IUUC-Eca-033445	Equus caballus	94.07	0.00e+00	1504.00
IUUC-Eeu-035247	Erinaceus europaeus	94.66	0.00e+00	1374.00
IUUC-Fca-035489	Felis catus	90.73	0.00e+00	1447.00
IUUC-Fal-037604	Ficedula albicollis	87.74	0.00e+00	1630.00
IUUC-Gmo-039674	Gadus morhua	74.47	0.00e+00	1348.00
IUUC-Gga-040703	Gallus gallus	89.86	0.00e+00	1678.00
IUUC-Gac-042020	Gasterosteus aculeatus	77.37	0.00e+00	1383.00
IUUC-Ggo-045332	Gorilla gorilla	93.50	0.00e+00	1656.00
IUUC-Hsa-045968	Homo sapiens	96.00	0.00e+00	1761.00
IUUC-Lch-050443	Latimeria chalumnae	83.09	0.00e+00	1378.00
IUUC-Loc-052662	Lepisosteus oculatus	77.62	0.00e+00	1398.00
IUUC-Laf-053850	Loxodonta africana	92.82	0.00e+00	1699.00
IUUC-Mcc-055821	Macaca mulatta	95.52	0.00e+00	1722.00
IUUC-Meu-056712	Macropus eugenii	78.42	0.00e+00	722.00
IUUC-Mmr-060798	Microcebus murinus	90.76	0.00e+00	1619.00
IUUC-Mdo-062173	Monodelphis domestica	92.36	0.00e+00	1751.00
IUUC-Mmu-064136	Mus musculus	93.45	0.00e+00	1711.00
IUUC-Mpu-066765	Mustela putorius furo	94.38	0.00e+00	1689.00
IUUC-Mlu-067565	Myotis lucifugus	91.48	0.00e+00	1487.00
IUUC-Opr-071044	Ochotona princeps	94.58	0.00e+00	1174.00
IUUC-Ont-072044	Oreochromis niloticus	75.86	0.00e+00	1424.00
IUUC-Oan-073032	Ornithorhynchus anatinus	89.21	0.00e+00	1373.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.48	0.00e+00	1646.00
IUUC-Ola-087467	Oryzias latipes	77.51	0.00e+00	1413.00
IUUC-Oga-088460	Otolemur garnettii	89.41	0.00e+00	1484.00
IUUC-Oar-090198	Ovis aries	93.86	0.00e+00	1673.00
IUUC-Ptr-090939	Pan troglodytes	96.00	0.00e+00	1761.00
IUUC-Pan-092284	Papio anubis	95.70	0.00e+00	1758.00
IUUC-Psi-093645	Pelodiscus sinensis	90.88	0.00e+00	1700.00
IUUC-Pma-094364	Petromyzon marinus	80.91	0.00e+00	843.00
IUUC-Pab-098088	Pongo abelii	95.75	0.00e+00	1736.00
IUUC-Pca-100714	Procavia capensis	82.64	0.00e+00	1158.00
IUUC-Pva-102354	Pteropus vampyrus	91.87	0.00e+00	1600.00
IUUC-Rno-105318	Rattus norvegicus	92.62	0.00e+00	1662.00
IUUC-Sha-107482	Sarcophilus harrisii	93.08	0.00e+00	1542.00
IUUC-Ssc-115950	Sus scrofa	67.60	0.00e+00	1086.00
IUUC-Tgu-117130	Taeniopygia guttata	90.62	0.00e+00	1658.00
IUUC-Tru-118610	Takifugu rubripes	77.49	0.00e+00	1431.00
IUUC-Tsy-119492	Tarsius syrichta	88.67	0.00e+00	1560.00
IUUC-Tni-120113	Tetraodon nigroviridis	72.01	0.00e+00	1305.00
IUUC-Tbe-127441	Tupaia belangeri	85.22	0.00e+00	723.00
IUUC-Ttr-128235	Tursiops truncatus	83.88	0.00e+00	1422.00
IUUC-Xtr-132859	Xenopus tropicalis	86.72	0.00e+00	1604.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence