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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064091
Ensembl Protein ID ENSMUSP00000099790.3
UniProt Accession P42567; Q8C431; EPS15_MOUSE
Genbank Protein ID AAA02912.1; BAC38796.1; CAM13653.1
Protein Name Epidermal growth factor receptor substrate 15; Protein AF-1p
Genbank Nucleotide ID L21768; AK083176; AL669905
Gene Name Eps15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028552.13 ENSMUST00000102729.9 ENSMUSP00000099790.3
ENSMUSG00000028552.13 ENSMUST00000176251.7 ENSMUSP00000135034.1
ENSMUSG00000028552.13 ENSMUST00000177089.7 ENSMUSP00000134922.1
ENSMUSG00000028552.13 ENSMUST00000175776.7 ENSMUSP00000135270.1
ENSMUSG00000028552.13 ENSMUST00000132165.8 ENSMUSP00000118949.2
ENSMUSG00000028552.13 ENSMUST00000030281.11 ENSMUSP00000030281.5
ENSMUSG00000028552.13 ENSMUST00000177192.1 ENSMUSP00000135755.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11919637
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Alpha-Helix/DUIM 88.93 0.00e+00 1270.00 IUUC-Hsa-046286
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts (via UIM repeats) with CORO7 (when ubiquitinated at 'Lys-472') (By similarity). Interacts with FCHO1 (By similarity). Interacts with FCHO2. Interacts with SGIP1. Interacts (via EH domains) with DAB2. Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1. Interacts with UBQLN2 (By similarity).
 Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts (via UIM repeats) with CORO7 (when ubiquitinated at 'Lys-472') (By similarity). Interacts with FCHO1 (By similarity). Interacts with FCHO2. Interacts with SGIP1. Interacts (via EH domains) with DAB2. Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1. Interacts with UBQLN2 (By similarity).
Protein Sequence
(Fasta)
MAAAAQLSLT QLSSGNPVYE KYYRQVEAGN TGRVLALDAA AFLKKSGLPD LILGKIWDLA 60
DTDGKGVLSK QEFFVALRLV ACAQNGLEVS LSSLSLAVPP PRFHDSSSPL LTSGPSVAEL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064091|UBD,UIM;UBD,DUIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCGGCGTG AGGAGGGAAG TTGTCGAAGT TCGGGGAGAC GCCCGGCCGC CGGCCTCGCC 60
TACGGCCTGT CCCTCCGCCT CCTTCCCGCC CCGGGCCCCC GTCCGTCCGT CCTTCCTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064091|UBD,UIM;UBD,DUIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR003903--UIM_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50330--UIM
Pfam

PF12763--EF-hand_4
SMART

SM00054--EFh
SM00027--EH
SM00726--UIM
Gene Ontology

GO:0016235--C:aggresome
GO:0030122--C:AP-2 adaptor complex
GO:0016324--C:apical plasma membrane
GO:0009925--C:basal plasma membrane
GO:0060170--C:ciliary membrane
GO:0030132--C:clathrin coat of coated pit
GO:0005905--C:clathrin-coated pit
GO:0030136--C:clathrin-coated vesicle
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0045296--F:cadherin binding
GO:0005509--F:calcium ion binding
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0017124--F:SH3 domain binding
GO:0048268--P:clathrin coat assembly
GO:0032456--P:endocytic recycling
GO:0006895--P:Golgi to endosome transport
GO:0001921--P:positive regulation of receptor recycling
GO:0015031--P:protein transport
GO:0019065--P:receptor-mediated endocytosis of virus by host cell
GO:0042127--P:regulation of cell proliferation
GO:0046718--P:viral entry into host cell
KEGG mmu:13858
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001596 Ailuropoda melanoleuca 87.04 0.00e+00 1321.00
IUUC-Apl-003288 Anas platyrhynchos 72.97 0.00e+00 1067.00
IUUC-Aca-005333 Anolis carolinensis 68.88 0.00e+00 1059.00
IUUC-Acl-008193 Aspergillus clavatus 29.58 6.00e-21 97.10
IUUC-Ang-009642 Aspergillus niger 27.44 2.00e-34 141.00
IUUC-Bta-013028 Bos taurus 87.50 0.00e+00 1367.00
IUUC-Bol-015187 Brassica oleracea 38.04 7.00e-13 69.30
IUUC-Bra-017706 Brassica rapa 38.04 2.00e-12 68.20
IUUC-Cja-019821 Callithrix jacchus 87.01 0.00e+00 1400.00
IUUC-Cfa-021233 Canis familiaris 87.41 0.00e+00 1066.00
IUUC-Cpo-022339 Cavia porcellus 87.64 0.00e+00 1402.00
IUUC-Csa-024072 Chlorocebus sabaeus 87.70 0.00e+00 1340.00
IUUC-Cho-025000 Choloepus hoffmanni 70.42 0.00e+00 1043.00
IUUC-Csv-025925 Ciona savignyi 65.96 1.00e-33 135.00
IUUC-Cme-027270 Cyanidioschyzon merolae 30.83 8.00e-19 89.40
IUUC-Dre-027504 Danio rerio 60.75 2.00e-163 570.00
IUUC-Dno-029498 Dasypus novemcinctus 83.46 0.00e+00 1331.00
IUUC-Dor-030630 Dipodomys ordii 85.25 0.00e+00 1346.00
IUUC-Ete-032737 Echinops telfairi 75.00 0.00e+00 839.00
IUUC-Eca-033328 Equus caballus 88.40 0.00e+00 1375.00
IUUC-Eeu-035267 Erinaceus europaeus 79.27 0.00e+00 870.00
IUUC-Fca-035511 Felis catus 87.69 0.00e+00 1384.00
IUUC-Fal-036796 Ficedula albicollis 71.74 0.00e+00 1062.00
IUUC-Gmo-038971 Gadus morhua 58.11 2.00e-159 556.00
IUUC-Gga-040315 Gallus gallus 71.70 0.00e+00 1073.00
IUUC-Gac-042011 Gasterosteus aculeatus 51.67 0.00e+00 660.00
IUUC-Ggo-045493 Gorilla gorilla 83.35 0.00e+00 1285.00
IUUC-Hsa-046286 Homo sapiens 88.93 0.00e+00 1397.00
IUUC-Loc-052749 Lepisosteus oculatus 51.59 9.00e-157 547.00
IUUC-Laf-054158 Loxodonta africana 86.31 0.00e+00 1353.00
IUUC-Mcc-055325 Macaca mulatta 89.16 0.00e+00 1385.00
IUUC-Mtr-058311 Medicago truncatula 34.48 6.00e-13 70.50
IUUC-Mga-060058 Meleagris gallopavo 70.80 0.00e+00 1101.00
IUUC-Mmr-061060 Microcebus murinus 89.05 0.00e+00 1391.00
IUUC-Mpu-065932 Mustela putorius furo 87.05 0.00e+00 1359.00
IUUC-Mlu-067488 Myotis lucifugus 86.68 0.00e+00 1356.00
IUUC-Nle-068996 Nomascus leucogenys 89.04 0.00e+00 1380.00
IUUC-Ont-071424 Oreochromis niloticus 54.75 0.00e+00 642.00
IUUC-Oan-073457 Ornithorhynchus anatinus 66.80 0.00e+00 735.00
IUUC-Ocu-074535 Oryctolagus cuniculus 88.37 0.00e+00 1380.00
IUUC-Ola-087107 Oryzias latipes 55.77 4.00e-141 495.00
IUUC-Oga-088532 Otolemur garnettii 86.10 0.00e+00 1348.00
IUUC-Oar-089833 Ovis aries 87.86 0.00e+00 1393.00
IUUC-Ptr-090733 Pan troglodytes 88.93 0.00e+00 1377.00
IUUC-Pan-092491 Papio anubis 84.65 0.00e+00 1251.00
IUUC-Psi-094063 Pelodiscus sinensis 73.24 0.00e+00 1102.00
IUUC-Ppa-095464 Physcomitrella patens 21.79 6.00e-13 70.50
IUUC-Pab-098749 Pongo abelii 89.43 0.00e+00 1406.00
IUUC-Pca-100378 Procavia capensis 73.60 0.00e+00 858.00
IUUC-Ppe-102036 Prunus persica 35.16 9.00e-12 66.20
IUUC-Pva-102739 Pteropus vampyrus 86.45 0.00e+00 1217.00
IUUC-Ptt-103746 Puccinia triticina 37.50 2.00e-20 95.10
IUUC-Rno-105042 Rattus norvegicus 92.99 0.00e+00 1419.00
IUUC-Sce-106303 Saccharomyces cerevisiae 27.75 3.00e-31 131.00
IUUC-Sly-111403 Solanum lycopersicum 33.33 2.00e-12 68.60
IUUC-Sar-113358 Sorex araneus 69.20 0.00e+00 874.00
IUUC-Sre-114981 Sporisorium reilianum 36.45 4.00e-30 127.00
IUUC-Ssc-115746 Sus scrofa 86.45 0.00e+00 1353.00
IUUC-Tgu-117351 Taeniopygia guttata 71.69 0.00e+00 1056.00
IUUC-Tru-117870 Takifugu rubripes 56.32 0.00e+00 707.00
IUUC-Tsy-118873 Tarsius syrichta 79.81 0.00e+00 889.00
IUUC-Tni-120351 Tetraodon nigroviridis 54.58 0.00e+00 699.00
IUUC-Tca-121631 Theobroma cacao 45.45 6.00e-12 67.00
IUUC-Tbe-127307 Tupaia belangeri 86.28 0.00e+00 1297.00
IUUC-Ttr-128775 Tursiops truncatus 84.29 0.00e+00 1254.00
IUUC-Vpa-130684 Vicugna pacos 82.27 0.00e+00 1298.00
IUUC-Xtr-132716 Xenopus tropicalis 58.17 0.00e+00 867.00
IUUC-Xma-133907 Xiphophorus maculatus 51.53 2.00e-178 619.00
Created Date 25-Jun-2017

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