iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-047951

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AGTP01030681

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000006982.2	ENSSTOT00000007001.2	ENSSTOP00000006256.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-88	296.9	195	824

Active Site

Position(s)	Description	Evidence
204	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
760	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.............kkkeklneenp.........kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e                                  ep g+l+ ++ ++++e++++kk+ 
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkieppD---------LalteplevnLEPPGPLTLAMSQFLNEMQETKKGI 274
           5******************************86666666654441.........04444455558899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 275  VTPKELFAQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSIPSFVDRIFGGELT 363
           *************************************************************99999999999***************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec +vs  +e+fldlslpv ++++ kk+                                                       
   Q: 364  STIMCDECSTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdndsyikerhdipsgtskhlqkkakkqakkqakn 452
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  qrrqqkiqgkvlhlndictidhpedneceaemslqeeveiksnhisqeevthkefcvnqkdlngqekmienitdnqksieeidiknidm 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  dndleelasstsectrnlngtflkegsngevdissgfknlnlnavlqpdeidieilndshtsgtkvyevvnedpetafctlanrdtlnt 630
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 631  decSVQYCLYQFTRNEKLRDANKLLCEVCTRRQYngpkantkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 717
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 718  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKArtanshlsnlilhgdipqdfemesTKGQWFHISDTHVQA 806
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 807  VPTAKVLN---SQAYLLFYER 824
           ********...********98 PP

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPTDDSSESS EPICRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYMIPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGGGGCAC GGTGGATTCG GCTCTGTTGC TCTCTATTCG TCACCGAGAG GAAGACGGAG 60
CCGGCCGCCT AGCCCAAAGG CCCATTAGGG GATGCAGTTA TGGGCGCTGT CACCGTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	35.75	6.00e-29	122.00
IUUC-Aml-001931	Ailuropoda melanoleuca	90.68	0.00e+00	1411.00
IUUC-Atr-003015	Amborella trichopoda	31.90	3.00e-37	150.00
IUUC-Apl-004145	Anas platyrhynchos	62.99	0.00e+00	914.00
IUUC-Aca-004314	Anolis carolinensis	59.57	0.00e+00	902.00
IUUC-Aly-006422	Arabidopsis lyrata	28.62	5.00e-30	126.00
IUUC-Ath-006732	Arabidopsis thaliana	32.82	8.00e-34	139.00
IUUC-Ame-011659	Astyanax mexicanus	48.86	2.00e-109	389.00
IUUC-Bta-013362	Bos taurus	90.81	0.00e+00	1407.00
IUUC-Bdi-014465	Brachypodium distachyon	31.40	7.00e-32	132.00
IUUC-Bol-015941	Brassica oleracea	29.52	1.00e-33	138.00
IUUC-Bra-016751	Brassica rapa	28.81	3.00e-31	130.00
IUUC-Cja-019177	Callithrix jacchus	92.14	0.00e+00	1461.00
IUUC-Cfa-020051	Canis familiaris	90.81	0.00e+00	1419.00
IUUC-Cpo-021886	Cavia porcellus	82.05	0.00e+00	1304.00
IUUC-Csa-024103	Chlorocebus sabaeus	92.38	0.00e+00	1471.00
IUUC-Cho-024315	Choloepus hoffmanni	77.43	8.00e-132	464.00
IUUC-Cin-025775	Ciona intestinalis	52.48	3.00e-41	160.00
IUUC-Csv-026075	Ciona savignyi	54.08	1.00e-58	220.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	4.00e-20	92.80
IUUC-Dre-028388	Danio rerio	50.77	3.00e-119	422.00
IUUC-Dno-029409	Dasypus novemcinctus	88.15	0.00e+00	1398.00
IUUC-Dor-030443	Dipodomys ordii	78.96	0.00e+00	653.00
IUUC-Ete-032807	Echinops telfairi	83.73	0.00e+00	680.00
IUUC-Eca-033479	Equus caballus	91.54	0.00e+00	1451.00
IUUC-Eeu-034835	Erinaceus europaeus	84.10	0.00e+00	676.00
IUUC-Fca-036320	Felis catus	91.29	0.00e+00	1462.00
IUUC-Fal-037029	Ficedula albicollis	59.88	0.00e+00	850.00
IUUC-Gmo-039480	Gadus morhua	52.35	6.00e-114	404.00
IUUC-Gga-040527	Gallus gallus	63.92	0.00e+00	923.00
IUUC-Gac-042343	Gasterosteus aculeatus	50.34	2.00e-113	403.00
IUUC-Gma-044402	Glycine max	28.21	2.00e-33	137.00
IUUC-Ggo-045598	Gorilla gorilla	92.02	0.00e+00	1462.00
IUUC-Hsa-046598	Homo sapiens	91.66	0.00e+00	1449.00
IUUC-Hvu-047146	Hordeum vulgare	29.14	3.00e-29	124.00
IUUC-Lch-050536	Latimeria chalumnae	52.15	0.00e+00	758.00
IUUC-Lpe-050703	Leersia perrieri	30.03	6.00e-29	122.00
IUUC-Loc-051814	Lepisosteus oculatus	56.65	9.00e-128	450.00
IUUC-Laf-053732	Loxodonta africana	86.63	0.00e+00	1402.00
IUUC-Mcc-054661	Macaca mulatta	92.74	0.00e+00	1472.00
IUUC-Meu-055967	Macropus eugenii	73.12	5.00e-157	548.00
IUUC-Mtr-057945	Medicago truncatula	30.54	4.00e-33	136.00
IUUC-Mga-059551	Meleagris gallopavo	62.86	0.00e+00	929.00
IUUC-Mvi-060391	Microbotryum violaceum	32.65	3.00e-19	90.50
IUUC-Mmr-061747	Microcebus murinus	93.08	0.00e+00	1441.00
IUUC-Mdo-062220	Monodelphis domestica	68.92	0.00e+00	1051.00
IUUC-Mmu-063582	Mus musculus	81.91	0.00e+00	1254.00
IUUC-Mac-064941	Musa acuminata	33.83	2.00e-38	154.00
IUUC-Mpu-066339	Mustela putorius furo	90.57	0.00e+00	1447.00
IUUC-Mlu-067511	Myotis lucifugus	84.99	0.00e+00	1333.00
IUUC-Nle-069252	Nomascus leucogenys	92.50	0.00e+00	1469.00
IUUC-Opr-070969	Ochotona princeps	85.84	0.00e+00	1310.00
IUUC-Ont-071786	Oreochromis niloticus	50.94	9.00e-116	410.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.73	0.00e+00	1410.00
IUUC-Oba-075094	Oryza barthii	31.19	1.00e-32	135.00
IUUC-Obr-076743	Oryza brachyantha	31.27	1.00e-31	132.00
IUUC-Ogl-077739	Oryza glaberrima	31.19	7.00e-33	135.00
IUUC-Ogu-078851	Oryza glumaepatula	31.19	1.00e-32	135.00
IUUC-Oin-079402	Oryza indica	31.19	1.00e-32	135.00
IUUC-Olo-080431	Oryza longistaminata	31.19	1.00e-32	135.00
IUUC-Ome-081580	Oryza meridionalis	31.19	1.00e-32	134.00
IUUC-Oni-082644	Oryza nivara	31.19	1.00e-32	135.00
IUUC-Opu-083452	Oryza punctata	30.03	3.00e-32	134.00
IUUC-Oru-084546	Oryza rufipogon	31.19	1.00e-32	135.00
IUUC-Osa-085858	Oryza sativa	31.19	1.00e-32	135.00
IUUC-Oga-088713	Otolemur garnettii	90.57	0.00e+00	1442.00
IUUC-Oar-089887	Ovis aries	91.17	0.00e+00	1420.00
IUUC-Ptr-091670	Pan troglodytes	92.02	0.00e+00	1462.00
IUUC-Pan-092293	Papio anubis	92.74	0.00e+00	1472.00
IUUC-Psi-093101	Pelodiscus sinensis	67.10	0.00e+00	949.00
IUUC-Ppa-095622	Physcomitrella patens	30.39	6.00e-35	142.00
IUUC-Pfo-097202	Poecilia formosa	46.46	0.00e+00	648.00
IUUC-Pab-098773	Pongo abelii	91.94	0.00e+00	1137.00
IUUC-Pop-099136	Populus trichocarpa	30.57	3.00e-40	160.00
IUUC-Pca-101069	Procavia capensis	71.54	0.00e+00	876.00
IUUC-Ppe-101794	Prunus persica	30.41	1.00e-34	141.00
IUUC-Pva-103092	Pteropus vampyrus	86.93	0.00e+00	690.00
IUUC-Rno-105237	Rattus norvegicus	82.63	0.00e+00	1265.00
IUUC-Sha-106889	Sarcophilus harrisii	73.04	0.00e+00	1126.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	28.32	2.00e-11	64.30
IUUC-Sit-110283	Setaria italica	30.90	9.00e-30	125.00
IUUC-Sly-111487	Solanum lycopersicum	29.95	5.00e-40	159.00
IUUC-Stu-112820	Solanum tuberosum	28.92	1.00e-38	154.00
IUUC-Sar-113530	Sorex araneus	82.61	0.00e+00	1304.00
IUUC-Sbi-113785	Sorghum bicolor	39.35	3.00e-25	110.00
IUUC-Ssc-116091	Sus scrofa	89.89	0.00e+00	1387.00
IUUC-Tgu-117478	Taeniopygia guttata	59.31	0.00e+00	870.00
IUUC-Tru-118640	Takifugu rubripes	53.04	1.00e-118	420.00
IUUC-Tsy-119042	Tarsius syrichta	77.83	0.00e+00	909.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.98	2.00e-179	622.00
IUUC-Tca-121701	Theobroma cacao	29.01	2.00e-38	154.00
IUUC-Tae-125785	Triticum aestivum	29.45	1.00e-27	118.00
IUUC-Tur-126788	Triticum urartu	29.14	3.00e-27	116.00
IUUC-Tbe-127309	Tupaia belangeri	77.79	0.00e+00	1116.00
IUUC-Ttr-128271	Tursiops truncatus	90.33	0.00e+00	1436.00
IUUC-Vpa-130674	Vicugna pacos	90.86	0.00e+00	1328.00
IUUC-Xtr-131869	Xenopus tropicalis	53.02	0.00e+00	795.00
IUUC-Xma-134195	Xiphophorus maculatus	53.57	4.00e-118	418.00
IUUC-Zma-135157	Zea mays	31.27	2.00e-27	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence