iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090542

Ensembl Protein ID

ENSPTRP00000013836.5

UniProt Accession

H2QB32; H2QB32_PANTR

Genbank Protein ID

ENSPTRP00000013836

Protein Name

Nucleotide-binding oligomerization domain-containing protein 2

Genbank Nucleotide ID

AACZ03103060

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000008106.5	ENSPTRT00000014943.5	ENSPTRP00000013836.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	7.10e-24	84.2	168	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaae 56
           +e+rl+++t+++r+r+lLd+++v++++l++fll++++el+++ a + +++++++
   Q: 168  DEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKK 221
           8***************************************************93 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGEEGGSVSH DEEERASVLL GHSLGCEMCS QEAFQAQRSQ LVELLVSGSL EGFESVLDWL 60
LSWEVLSWED YEGFHLLGQP LSHLARRLLD TVWNKGTWAC QKLIAAAQEA QADSQSPKLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAAG AGGGTGGTTC AGTCTCTCAC GATGAGGAGG AAAGAGCAAG TGTCCTCCTC 60
GGACATTCTC TGGGTAAGAG GAGCAGGCAT TGTCCTGTCT CAGCTTGATT CTCAGCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

KEGG

ptr:454083

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.83	0.00e+00	1496.00
IUUC-Ame-011021	Astyanax mexicanus	45.97	0.00e+00	878.00
IUUC-Bta-013241	Bos taurus	81.84	0.00e+00	1632.00
IUUC-Cja-019633	Callithrix jacchus	91.16	0.00e+00	1388.00
IUUC-Cfa-020039	Canis familiaris	83.42	0.00e+00	1638.00
IUUC-Cpo-022337	Cavia porcellus	80.17	0.00e+00	1544.00
IUUC-Csa-023906	Chlorocebus sabaeus	96.24	0.00e+00	1922.00
IUUC-Dre-027568	Danio rerio	48.22	0.00e+00	833.00
IUUC-Dno-029098	Dasypus novemcinctus	81.15	0.00e+00	1522.00
IUUC-Dor-031102	Dipodomys ordii	73.35	0.00e+00	701.00
IUUC-Ete-032943	Echinops telfairi	77.31	0.00e+00	1122.00
IUUC-Eca-034310	Equus caballus	84.87	0.00e+00	1631.00
IUUC-Eeu-034589	Erinaceus europaeus	83.48	5.00e-164	572.00
IUUC-Fca-036252	Felis catus	79.22	0.00e+00	818.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.40	0.00e+00	818.00
IUUC-Ggo-044861	Gorilla gorilla	99.42	0.00e+00	1934.00
IUUC-Hsa-046093	Homo sapiens	98.94	0.00e+00	1925.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	81.57	0.00e+00	1481.00
IUUC-Lch-049454	Latimeria chalumnae	54.00	0.00e+00	927.00
IUUC-Laf-053553	Loxodonta africana	83.89	0.00e+00	1519.00
IUUC-Mcc-055772	Macaca mulatta	96.26	0.00e+00	1857.00
IUUC-Meu-056785	Macropus eugenii	69.15	7.00e-116	411.00
IUUC-Mmr-060596	Microcebus murinus	83.67	0.00e+00	1626.00
IUUC-Mdo-062983	Monodelphis domestica	68.02	0.00e+00	1129.00
IUUC-Mmu-063951	Mus musculus	78.26	0.00e+00	1534.00
IUUC-Mpu-066412	Mustela putorius furo	83.32	0.00e+00	1632.00
IUUC-Mlu-067601	Myotis lucifugus	81.13	0.00e+00	1456.00
IUUC-Nle-069913	Nomascus leucogenys	98.03	0.00e+00	1565.00
IUUC-Opr-070999	Ochotona princeps	84.58	0.00e+00	996.00
IUUC-Ont-072512	Oreochromis niloticus	46.60	0.00e+00	884.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.40	0.00e+00	1106.00
IUUC-Ocu-074837	Oryctolagus cuniculus	86.35	0.00e+00	1645.00
IUUC-Ola-086555	Oryzias latipes	45.73	0.00e+00	815.00
IUUC-Oga-088909	Otolemur garnettii	84.13	0.00e+00	1625.00
IUUC-Oar-089315	Ovis aries	81.16	0.00e+00	1566.00
IUUC-Pan-092545	Papio anubis	95.86	0.00e+00	1883.00
IUUC-Pma-094167	Petromyzon marinus	34.49	9.00e-66	244.00
IUUC-Ppa-095344	Physcomitrella patens	32.63	1.00e-06	48.90
IUUC-Pfo-096976	Poecilia formosa	44.82	0.00e+00	829.00
IUUC-Pab-098481	Pongo abelii	98.65	0.00e+00	1914.00
IUUC-Pca-100135	Procavia capensis	77.06	0.00e+00	1304.00
IUUC-Pva-102127	Pteropus vampyrus	81.50	0.00e+00	1462.00
IUUC-Rno-105783	Rattus norvegicus	80.30	0.00e+00	1518.00
IUUC-Sar-113448	Sorex araneus	74.26	0.00e+00	927.00
IUUC-Tru-118708	Takifugu rubripes	44.54	0.00e+00	781.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.95	2.00e-33	135.00
IUUC-Tbe-127661	Tupaia belangeri	87.15	0.00e+00	857.00
IUUC-Ttr-128318	Tursiops truncatus	77.96	0.00e+00	1454.00
IUUC-Vpa-130502	Vicugna pacos	75.53	3.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence