iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006782

UUCD1 version

UUC-ArT-01608

Ensembl Protein ID

AT2G40930.1

UniProt Accession

O22207; Q9SEX3; UBP5_ARATH

Genbank Protein ID

AAF21246.1; AAB86453.2; AEC09900.1; ANM61508.1; AAM20552.1; AAN15619.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5

Genbank Nucleotide ID

AF048705; AC002409; CP002685; CP002685; AY099701; BT000300

Gene Name

UBP5; At2g40930; T20B5.13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G40930	AT2G40930.1	AT2G40930.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	10898935

Classification

Family	E-value	Score	Start	End
DUB/USP	2.80e-110	369.5	317	916

Active Site

Position(s)	Description	Evidence
326	Nucleophile
874	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           tGl NlgNtC+mNS++QcL+++pe+++++ e +++++n++np ++ gel+ ++ +l+++lw   ++ ++pr ++++l+++a++fsgy+q+D+qE+laf
   Q: 317  TGLLNLGNTCFMNSAIQCLVHTPEFASYFQEDYHQEINWQNPLGMVGELALAFGDLLRKLWAPGRTPIAPRPFKAKLARFAPQFSGYNQHDSQELLAF 414
           7************************************************************************************************* PP
   S: 99   lldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........ 185
           lld+l+e+l++ k+kp+ +++++d   ++e  de ++++  +n+s+i+d+ qgq+ks+++c+ c++vs++++pf++lslp++ +++++ +        
   Q: 415  LLDGLHEDLNRVKHKPYINSRDADgrpDEEVADEFWKNHIARNDSIIVDVCQGQYKSTLVCPICNKVSVTFDPFMYLSLPLQFNTTRAITvtvfscdk 512
           *****************99998872224556666***************************************************99888******** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 513  talpstitvnvskqgrcrdliqaltnacslkqseelklaeirnnfihrlfedpliplssikdddhlaayklskssenttllrlvlrrrdqkagerest 610
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 611  vqlkpcgtpllssascgdaltkgkihclvqnmlspfrreesvgkkgnsdssiperrsarfnnteeedkvgglkkakksnssdlgasklslqlidednk 708
           ************************************************************************************************** PP
   S: 186  ............................................................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
                                                                       sl  cLe+f +ee l  +++++c++c+++++a+kkl+l
   Q: 709  tinlpdneaeamklpssatvtiyldwtpelsgmyditcleslpevlkygpttkkarseplSLYACLEAFLREEPLVPDEMWFCPQCNERRQASKKLDL 806
           ************************************************************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevke 319
           ++lPevL++hLkRfs+s+  ++++k+++ v+fp++ Ldl++++++++ +q  ++ YeL+a  +H+G+++sGHY+a++k  +++ W++fdDs++++++e
   Q: 807  WRLPEVLVIHLKRFSYSR--SMKHKLETFVNFPIHdLDLTKYVANKNLSQ--PQLYELYALTNHYGGMGSGHYTAHIKLLDDSrWYNFDDSHISHINE 900
           **************9987..6999*********************99888..**************************966556************** PP
   S: 320  eevleetgstaYvlfYkrr 338
           ++v++     aYvlfY+r+
   Q: 901  DDVKS---GAAYVLFYRRK 916
           *****...9*******985 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Protein Sequence
(Fasta)

MAEVSMGSSS SSTDLSPEEE RVFIRDIAIA AEANSKEGDT FYLITQRWWQ EWIEYVNQDQ 60
PCNTNDGSSL SEHCDSPGSS TLKKPSRIDN SDLIYDSSLE DPSNTSEIIE TLQEGRDYVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAAATTGT TTTTTTTCTT AAATTTATAA ATGGTGGTGG ATTTTTTTGG GGACCTATTT 60
CGAAATGACT ATCTAAGGAG CGAAGCCAGC AAGGATCTGT TTCAGAGAGA AAAAAAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G40930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001852	Ailuropoda melanoleuca	35.70	2.00e-149	522.00
IUUC-Atr-002675	Amborella trichopoda	62.21	0.00e+00	1068.00
IUUC-Aly-005644	Arabidopsis lyrata	97.67	0.00e+00	1764.00
IUUC-Ame-010757	Astyanax mexicanus	37.21	8.00e-136	477.00
IUUC-Bta-013128	Bos taurus	35.59	8.00e-149	520.00
IUUC-Bdi-014523	Brachypodium distachyon	59.78	0.00e+00	1070.00
IUUC-Bol-016335	Brassica oleracea	89.42	0.00e+00	1634.00
IUUC-Bra-016930	Brassica rapa	90.11	0.00e+00	1615.00
IUUC-Cja-019222	Callithrix jacchus	35.70	7.00e-150	524.00
IUUC-Cfa-020035	Canis familiaris	35.70	2.00e-149	522.00
IUUC-Cpo-022144	Cavia porcellus	35.39	8.00e-135	474.00
IUUC-Csa-023882	Chlorocebus sabaeus	35.70	5.00e-150	524.00
IUUC-Eca-034340	Equus caballus	35.91	2.00e-146	512.00
IUUC-Fca-035552	Felis catus	35.91	6.00e-148	517.00
IUUC-Gmo-038866	Gadus morhua	36.74	7.00e-89	321.00
IUUC-Gac-041679	Gasterosteus aculeatus	35.92	6.00e-152	531.00
IUUC-Gma-043037	Glycine max	68.38	0.00e+00	1207.00
IUUC-Ggo-045002	Gorilla gorilla	35.67	9.00e-146	510.00
IUUC-Hsa-046052	Homo sapiens	35.70	8.00e-150	523.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	35.80	2.00e-148	519.00
IUUC-Kpa-049332	Komagataella pastoris	32.48	3.00e-67	249.00
IUUC-Lpe-050892	Leersia perrieri	58.23	0.00e+00	1033.00
IUUC-Laf-053645	Loxodonta africana	35.70	1.00e-149	523.00
IUUC-Mcc-055586	Macaca mulatta	35.70	8.00e-150	523.00
IUUC-Mtr-058563	Medicago truncatula	66.14	0.00e+00	1212.00
IUUC-Mmr-061105	Microcebus murinus	35.16	5.00e-150	524.00
IUUC-Mac-065239	Musa acuminata	62.20	0.00e+00	1103.00
IUUC-Mpu-065868	Mustela putorius furo	34.97	2.00e-146	512.00
IUUC-Nle-069874	Nomascus leucogenys	35.75	6.00e-150	524.00
IUUC-Opr-071212	Ochotona princeps	34.34	2.00e-140	492.00
IUUC-Ont-071834	Oreochromis niloticus	35.70	7.00e-144	504.00
IUUC-Ocu-074573	Oryctolagus cuniculus	35.80	2.00e-150	526.00
IUUC-Oba-074976	Oryza barthii	58.97	0.00e+00	1029.00
IUUC-Obr-076301	Oryza brachyantha	59.98	0.00e+00	1039.00
IUUC-Ogu-078386	Oryza glumaepatula	58.97	0.00e+00	1028.00
IUUC-Oin-080145	Oryza indica	60.00	0.00e+00	1062.00
IUUC-Olo-080452	Oryza longistaminata	58.37	0.00e+00	1027.00
IUUC-Ome-081929	Oryza meridionalis	58.62	0.00e+00	1009.00
IUUC-Oni-083100	Oryza nivara	54.29	0.00e+00	911.00
IUUC-Opu-083518	Oryza punctata	58.78	0.00e+00	1046.00
IUUC-Oru-084337	Oryza rufipogon	59.45	0.00e+00	1049.00
IUUC-Oga-089022	Otolemur garnettii	36.01	1.00e-149	523.00
IUUC-Oar-089767	Ovis aries	35.39	5.00e-148	518.00
IUUC-Ptr-091319	Pan troglodytes	35.91	9.00e-150	523.00
IUUC-Pan-091968	Papio anubis	35.70	5.00e-150	524.00
IUUC-Pfo-097110	Poecilia formosa	35.19	5.00e-151	528.00
IUUC-Pab-098664	Pongo abelii	35.70	5.00e-150	524.00
IUUC-Pop-099866	Populus trichocarpa	68.42	0.00e+00	1231.00
IUUC-Ppe-101550	Prunus persica	68.73	0.00e+00	1249.00
IUUC-Pva-102394	Pteropus vampyrus	34.97	1.00e-142	499.00
IUUC-Sja-107748	Schizosaccharomyces japonicus	29.82	3.00e-92	332.00
IUUC-Sit-110601	Setaria italica	55.08	0.00e+00	807.00
IUUC-Sly-111726	Solanum lycopersicum	67.83	0.00e+00	1167.00
IUUC-Sar-113498	Sorex araneus	35.88	7.00e-149	520.00
IUUC-Ssc-115285	Sus scrofa	35.49	2.00e-149	522.00
IUUC-Tru-118298	Takifugu rubripes	38.83	7.00e-105	374.00
IUUC-Tsy-119433	Tarsius syrichta	32.94	2.00e-70	261.00
IUUC-Tca-121726	Theobroma cacao	68.95	0.00e+00	1201.00
IUUC-Tae-125515	Triticum aestivum	59.21	0.00e+00	1047.00
IUUC-Tur-126392	Triticum urartu	57.38	0.00e+00	991.00
IUUC-Ttr-128778	Tursiops truncatus	35.38	5.00e-133	468.00
IUUC-Vpa-130469	Vicugna pacos	35.35	3.00e-145	508.00
IUUC-Vvi-131005	Vitis vinifera	69.23	0.00e+00	1226.00
IUUC-Xma-133550	Xiphophorus maculatus	35.19	3.00e-150	525.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence