iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.00e-68	226.1	270	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +ke++++l++y+++n+deLt+++G+++++i+ke+ ++gW+kg  el+gk+G+fP+nF ++++
   Q: 270  AKEYCRTLFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG--ELNGKEGVFPDNFAVQIS 329
           689***************************************..9*************9986 PP

Organism

Mus musculus

Functional Description
(View)

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

Protein Sequence
(Fasta)

MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE 60
TEPKDDNLPI KRERQGNVAS LVQRISTYGL PAGGIQPHPQ TKAIKKKTKK RQCKVLFDYS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGCGGC CAAGCGCGCC GCGGGCGGAT GGAGTCGCTT CCCCGCCGCG CCTGAGCCGG 60
TGCACAGAAG GGGCCGCGGG GCCGCGCTCT CCCCGCCAGA GCCGCAGCAT GGGTAAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
KW-0832--Ubl conjugation

Interpro

IPR028445--CD2AP
IPR001452--SH3_domain

PROSITE

PS50002--SH3

Pfam

PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005938--C:cell cortex
GO:0005913--C:cell-cell adherens junction
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030139--C:endocytic vesicle
GO:0070062--C:extracellular exosome
GO:0031941--C:filamentous actin
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0017124--F:SH3 domain binding
GO:0051301--P:cell division
GO:0016477--P:cell migration
GO:0007067--P:mitotic nuclear division
GO:0032911--P:negative regulation of transforming growth factor beta1 production
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000249--P:regulation of actin cytoskeleton reorganization
GO:0048259--P:regulation of receptor-mediated endocytosis
GO:0016337--P:single organismal cell-cell adhesion
GO:0016050--P:vesicle organization

KEGG

mmu:12488

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001574	Ailuropoda melanoleuca	83.78	0.00e+00	884.00
IUUC-Apl-003573	Anas platyrhynchos	61.29	1.00e-145	509.00
IUUC-Aca-005118	Anolis carolinensis	61.36	7.00e-154	537.00
IUUC-Ame-010657	Astyanax mexicanus	50.99	3.00e-86	312.00
IUUC-Bta-012577	Bos taurus	81.80	0.00e+00	788.00
IUUC-Cja-020010	Callithrix jacchus	84.66	0.00e+00	857.00
IUUC-Cfa-020040	Canis familiaris	86.05	0.00e+00	909.00
IUUC-Cpo-021906	Cavia porcellus	78.48	0.00e+00	773.00
IUUC-Csa-024008	Chlorocebus sabaeus	85.29	0.00e+00	822.00
IUUC-Cho-024359	Choloepus hoffmanni	87.20	8.00e-52	198.00
IUUC-Cin-025154	Ciona intestinalis	59.26	1.00e-13	67.00
IUUC-Csv-026228	Ciona savignyi	39.13	2.00e-24	104.00
IUUC-Dre-027661	Danio rerio	55.20	1.00e-92	334.00
IUUC-Dno-029568	Dasypus novemcinctus	82.24	0.00e+00	798.00
IUUC-Dor-030286	Dipodomys ordii	74.21	0.00e+00	686.00
IUUC-Ete-032576	Echinops telfairi	81.71	1.00e-106	380.00
IUUC-Eca-033438	Equus caballus	84.82	0.00e+00	882.00
IUUC-Eeu-034588	Erinaceus europaeus	69.21	4.00e-136	478.00
IUUC-Fca-036597	Felis catus	85.34	0.00e+00	890.00
IUUC-Fal-037305	Ficedula albicollis	63.24	2.00e-157	549.00
IUUC-Gmo-039516	Gadus morhua	45.45	7.00e-63	235.00
IUUC-Gga-040979	Gallus gallus	64.41	2.00e-173	602.00
IUUC-Gac-041945	Gasterosteus aculeatus	51.14	1.00e-78	288.00
IUUC-Ggo-044488	Gorilla gorilla	86.23	0.00e+00	857.00
IUUC-Hsa-045909	Homo sapiens	85.92	0.00e+00	853.00
IUUC-Itr-049058	Ictidomys tridecemlineatus	86.22	3.00e-119	421.00
IUUC-Lch-049481	Latimeria chalumnae	56.00	2.00e-149	522.00
IUUC-Loc-052715	Lepisosteus oculatus	51.60	8.00e-129	454.00
IUUC-Lma-053035	Leptosphaeria maculans	27.61	2.00e-12	68.60
IUUC-Laf-053444	Loxodonta africana	82.06	0.00e+00	846.00
IUUC-Mcc-054844	Macaca mulatta	85.45	0.00e+00	823.00
IUUC-Meu-056491	Macropus eugenii	64.03	6.00e-171	594.00
IUUC-Mla-059069	Melampsora laricipopulina	41.38	5.00e-07	49.30
IUUC-Mga-060154	Meleagris gallopavo	63.78	3.00e-169	588.00
IUUC-Mmr-061099	Microcebus murinus	84.66	0.00e+00	858.00
IUUC-Mdo-062769	Monodelphis domestica	69.61	0.00e+00	731.00
IUUC-Mpu-066509	Mustela putorius furo	83.25	0.00e+00	803.00
IUUC-Mlu-067174	Myotis lucifugus	81.75	0.00e+00	834.00
IUUC-Nle-070147	Nomascus leucogenys	85.45	0.00e+00	858.00
IUUC-Opr-070752	Ochotona princeps	80.17	2.00e-153	535.00
IUUC-Ont-071810	Oreochromis niloticus	54.05	6.00e-99	355.00
IUUC-Oan-072731	Ornithorhynchus anatinus	70.78	2.00e-159	555.00
IUUC-Ocu-074331	Oryctolagus cuniculus	86.09	0.00e+00	848.00
IUUC-Ola-086404	Oryzias latipes	45.09	2.00e-88	320.00
IUUC-Oga-088200	Otolemur garnettii	84.98	0.00e+00	877.00
IUUC-Oar-090423	Ovis aries	80.25	0.00e+00	759.00
IUUC-Ptr-091230	Pan troglodytes	86.23	0.00e+00	860.00
IUUC-Pan-091823	Papio anubis	84.98	0.00e+00	823.00
IUUC-Psi-093127	Pelodiscus sinensis	60.60	8.00e-148	517.00
IUUC-Pfo-096539	Poecilia formosa	49.85	6.00e-89	322.00
IUUC-Pab-097666	Pongo abelii	85.92	0.00e+00	849.00
IUUC-Pca-100812	Procavia capensis	80.95	5.00e-125	441.00
IUUC-Pva-102260	Pteropus vampyrus	78.60	0.00e+00	692.00
IUUC-Rno-106038	Rattus norvegicus	93.25	0.00e+00	917.00
IUUC-Sha-106975	Sarcophilus harrisii	71.70	0.00e+00	713.00
IUUC-Sar-113386	Sorex araneus	82.93	1.00e-102	367.00
IUUC-Ssc-115569	Sus scrofa	88.66	4.00e-110	390.00
IUUC-Tgu-117104	Taeniopygia guttata	63.58	2.00e-168	586.00
IUUC-Tru-117649	Takifugu rubripes	50.51	7.00e-97	348.00
IUUC-Tsy-119258	Tarsius syrichta	77.59	0.00e+00	763.00
IUUC-Tni-120755	Tetraodon nigroviridis	44.18	4.00e-119	422.00
IUUC-Tbe-127842	Tupaia belangeri	66.97	3.00e-110	392.00
IUUC-Ttr-129205	Tursiops truncatus	84.42	0.00e+00	731.00
IUUC-Vpa-130434	Vicugna pacos	80.65	0.00e+00	677.00
IUUC-Xtr-132766	Xenopus tropicalis	57.93	2.00e-86	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence