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Tag Content
UUCD2 ID IUUC-Fca-035761
UUCD1 version UUC-FeC-00357
Ensembl Protein ID ENSFCAP00000009745.1
UniProt Accession M3WDD5; M3WDD5_FELCA
Genbank Protein ID ENSFCAP00000009745
Protein Name Nitric oxide synthase-interacting protein
Genbank Nucleotide ID AANG02113180
Gene Name NOSIP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSFCAG00000010497.2 ENSFCAT00000010500.2 ENSFCAP00000009745.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.30e-15 57.3 40 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP
   
Organism Felis catus
Functional Description
(View)

Functional Description


     Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
 Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Protein Sequence
(Fasta)
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Fca-035761|E3,U-box|Felis catus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCTACTTC CGGTCCTTTT TCCGGGCGGA AGTGGGCGTA GCGCTGAGGG GAAAACAGCC 60
CTCCTTTCCG GTGTAGGGGC ACAGTTGAAG AAGCGACGGA GGGTCGAGGA GTCGTTTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Fca-035761|E3,U-box|Felis catus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF15906--zf-NOSIP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination
KEGG fca:101096687
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000769 Aegilops tauschii 46.51 1.00e-16 81.30
IUUC-Aml-002069 Ailuropoda melanoleuca 93.63 1.00e-168 585.00
IUUC-Atr-002661 Amborella trichopoda 32.54 2.00e-30 126.00
IUUC-Aca-004630 Anolis carolinensis 75.75 7.00e-137 479.00
IUUC-Aly-006316 Arabidopsis lyrata 30.74 7.00e-30 124.00
IUUC-Ath-007000 Arabidopsis thaliana 30.42 3.00e-29 122.00
IUUC-Acl-008175 Aspergillus clavatus 33.63 1.00e-05 44.30
IUUC-Afl-008440 Aspergillus flavus 33.90 7.00e-06 45.10
IUUC-Afu-009012 Aspergillus fumigatus 34.78 3.00e-06 46.20
IUUC-Ani-009153 Aspergillus nidulans 32.54 1.80e-02 33.50
IUUC-Ang-009556 Aspergillus niger 33.90 7.00e-06 45.10
IUUC-Aor-009892 Aspergillus oryzae 33.90 7.00e-06 44.70
IUUC-Ate-010473 Aspergillus terreus 30.43 9.00e-05 42.40
IUUC-Ame-011874 Astyanax mexicanus 63.96 5.00e-111 393.00
IUUC-Bgr-012090 Blumeria graminis 25.44 1.00e-05 44.30
IUUC-Bta-012956 Bos taurus 96.36 3.00e-172 597.00
IUUC-Bci-013897 Botrytis cinerea 42.50 7.00e-10 58.20
IUUC-Bdi-014968 Brachypodium distachyon 30.43 4.00e-33 134.00
IUUC-Bol-015578 Brassica oleracea 30.94 2.00e-33 135.00
IUUC-Bra-017234 Brassica rapa 30.94 2.00e-33 135.00
IUUC-Cel-018637 Caenorhabditis elegans 42.28 5.00e-59 221.00
IUUC-Cja-019632 Callithrix jacchus 93.36 6.00e-168 582.00
IUUC-Cfa-020192 Canis familiaris 95.68 4.00e-171 593.00
IUUC-Cpo-021939 Cavia porcellus 91.03 1.00e-155 542.00
IUUC-Cre-023005 Chlamydomonas reinhardtii 34.22 2.00e-43 169.00
IUUC-Csa-023802 Chlorocebus sabaeus 93.36 3.00e-167 580.00
IUUC-Cho-024637 Choloepus hoffmanni 78.80 6.00e-84 303.00
IUUC-Cin-025180 Ciona intestinalis 51.99 3.00e-87 314.00
IUUC-Csv-026206 Ciona savignyi 54.42 1.00e-43 169.00
IUUC-Cgl-026696 Colletotrichum gloeosporioides 25.21 1.00e-13 70.50
IUUC-Cne-026827 Cryptococcus neoformans 36.36 1.00e-06 47.40
IUUC-Dre-028092 Danio rerio 65.46 1.00e-117 415.00
IUUC-Dno-029501 Dasypus novemcinctus 89.40 6.00e-145 506.00
IUUC-Dor-030542 Dipodomys ordii 90.43 6.00e-161 559.00
IUUC-Dse-031188 Dothistroma septosporum 24.86 6.00e-14 71.60
IUUC-Dme-031734 Drosophila melanogaster 47.48 2.00e-79 288.00
IUUC-Eca-033577 Equus caballus 96.68 2.00e-173 600.00
IUUC-Fox-037703 Fusarium oxysporum 24.02 1.00e-13 70.90
IUUC-Fso-038208 Fusarium solani 27.86 6.00e-13 68.20
IUUC-Gmo-038523 Gadus morhua 62.50 1.00e-63 235.00
IUUC-Ggr-040087 Gaeumannomyces graminis 41.03 6.00e-10 58.20
IUUC-Gac-042621 Gasterosteus aculeatus 59.26 9.00e-109 386.00
IUUC-Gma-042698 Glycine max 31.53 3.00e-32 132.00
IUUC-Ggo-045357 Gorilla gorilla 93.36 3.00e-167 580.00
IUUC-Hsa-046195 Homo sapiens 93.36 3.00e-167 580.00
IUUC-Hvu-047174 Hordeum vulgare 31.23 3.00e-35 141.00
IUUC-Itr-048487 Ictidomys tridecemlineatus 94.02 5.00e-163 566.00
IUUC-Lch-050569 Latimeria chalumnae 67.95 1.00e-115 408.00
IUUC-Lpe-050992 Leersia perrieri 35.92 4.00e-23 102.00
IUUC-Loc-052522 Lepisosteus oculatus 69.44 3.00e-117 414.00
IUUC-Lma-053254 Leptosphaeria maculans 39.24 1.00e-09 57.40
IUUC-Laf-053397 Loxodonta africana 95.05 5.00e-169 586.00
IUUC-Mcc-054681 Macaca mulatta 93.36 3.00e-167 580.00
IUUC-Meu-056723 Macropus eugenii 83.17 3.00e-149 520.00
IUUC-Mor-056961 Magnaporthe oryzae 37.27 3.00e-10 59.30
IUUC-Mpo-057359 Magnaporthe poae 24.72 8.00e-07 47.40
IUUC-Mtr-058063 Medicago truncatula 32.09 3.00e-33 135.00
IUUC-Mla-059004 Melampsora laricipopulina 30.57 7.00e-26 110.00
IUUC-Mvi-060460 Microbotryum violaceum 30.09 1.00e-25 110.00
IUUC-Mmr-060847 Microcebus murinus 95.68 7.00e-171 592.00
IUUC-Mdo-062480 Monodelphis domestica 84.16 5.00e-151 526.00
IUUC-Mmu-063809 Mus musculus 92.36 1.00e-164 571.00
IUUC-Mac-064870 Musa acuminata 31.53 6.00e-33 134.00
IUUC-Mpu-066322 Mustela putorius furo 96.70 8.00e-173 599.00
IUUC-Mlu-067556 Myotis lucifugus 92.76 5.00e-159 553.00
IUUC-Nfi-068440 Neosartorya fischeri 34.78 3.00e-06 46.20
IUUC-Ncr-068898 Neurospora crassa 38.46 9.00e-08 51.20
IUUC-Nle-070049 Nomascus leucogenys 93.69 1.00e-167 581.00
IUUC-Opr-070972 Ochotona princeps 90.16 6.00e-158 549.00
IUUC-Ont-071682 Oreochromis niloticus 66.56 2.00e-115 408.00
IUUC-Oan-073296 Ornithorhynchus anatinus 98.31 1.00e-32 131.00
IUUC-Ocu-074218 Oryctolagus cuniculus 90.71 2.00e-133 468.00
IUUC-Oba-075284 Oryza barthii 32.20 2.00e-34 139.00
IUUC-Obr-076651 Oryza brachyantha 31.86 2.00e-35 142.00
IUUC-Ogl-077899 Oryza glaberrima 32.20 2.00e-34 139.00
IUUC-Ogu-078477 Oryza glumaepatula 32.88 4.00e-35 141.00
IUUC-Oin-080011 Oryza indica 32.20 3.00e-34 138.00
IUUC-Olo-080545 Oryza longistaminata 32.18 4.00e-28 119.00
IUUC-Ome-081543 Oryza meridionalis 32.20 3.00e-34 138.00
IUUC-Oni-082955 Oryza nivara 32.20 3.00e-34 138.00
IUUC-Opu-083565 Oryza punctata 32.54 7.00e-35 140.00
IUUC-Oru-084474 Oryza rufipogon 32.20 3.00e-34 138.00
IUUC-Osa-085913 Oryza sativa 32.20 3.00e-34 138.00
IUUC-Ola-086851 Oryzias latipes 65.12 3.00e-118 417.00
IUUC-Olu-087724 Ostreococcus lucimarinus 33.01 2.00e-12 66.20
IUUC-Oga-087970 Otolemur garnettii 94.04 2.00e-167 581.00
IUUC-Oar-089756 Ovis aries 92.74 2.00e-160 557.00
IUUC-Ptr-091485 Pan troglodytes 92.36 9.00e-164 568.00
IUUC-Pan-091832 Papio anubis 93.69 7.00e-168 582.00
IUUC-Pma-094551 Petromyzon marinus 62.54 5.00e-108 383.00
IUUC-Pno-094830 Phaeosphaeria nodorum 27.27 4.00e-09 55.50
IUUC-Ppa-095255 Physcomitrella patens 30.10 1.00e-31 130.00
IUUC-Pfo-096373 Poecilia formosa 65.03 2.00e-116 412.00
IUUC-Pab-098247 Pongo abelii 93.36 3.00e-167 580.00
IUUC-Pop-099186 Populus trichocarpa 31.19 1.00e-30 127.00
IUUC-Pca-100677 Procavia capensis 92.00 1.00e-140 491.00
IUUC-Ppe-101403 Prunus persica 30.72 7.00e-31 127.00
IUUC-Pva-103000 Pteropus vampyrus 96.01 1.00e-172 598.00
IUUC-Pgr-103663 Puccinia graminis 30.86 7.00e-31 128.00
IUUC-Ptt-103712 Puccinia triticina 40.00 5.00e-09 54.70
IUUC-Pte-104287 Pyrenophora teres 27.66 1.00e-17 84.00
IUUC-Pyt-104579 Pyrenophora triticirepentis 26.57 6.00e-14 71.60
IUUC-Rno-106069 Rattus norvegicus 92.69 4.00e-165 573.00
IUUC-Sha-106553 Sarcophilus harrisii 84.16 3.00e-151 527.00
IUUC-Smo-108874 Selaginella moellendorffii 32.24 3.00e-38 152.00
IUUC-Sit-110307 Setaria italica 32.20 3.00e-33 135.00
IUUC-Sly-111094 Solanum lycopersicum 31.23 7.00e-32 130.00
IUUC-Stu-112363 Solanum tuberosum 31.56 1.00e-31 130.00
IUUC-Sar-113480 Sorex araneus 95.02 5.00e-160 556.00
IUUC-Sbi-113939 Sorghum bicolor 32.20 7.00e-34 137.00
IUUC-Ssc-115644 Sus scrofa 97.01 2.00e-173 600.00
IUUC-Tru-118781 Takifugu rubripes 65.15 3.00e-119 421.00
IUUC-Tni-119672 Tetraodon nigroviridis 73.56 2.00e-34 136.00
IUUC-Tca-121795 Theobroma cacao 31.89 8.00e-35 140.00
IUUC-Tre-122037 Trichoderma reesei 36.36 3.00e-08 52.80
IUUC-Tvi-122524 Trichoderma virens 26.12 1.00e-16 80.50
IUUC-Tae-122828 Triticum aestivum 31.56 2.00e-35 142.00
IUUC-Tur-126387 Triticum urartu 32.18 2.00e-29 123.00
IUUC-Tme-127111 Tuber melanosporum 40.00 2.00e-09 57.00
IUUC-Ttr-128227 Tursiops truncatus 96.35 9.00e-172 595.00
IUUC-Vda-129924 Verticillium dahliae 27.49 2.00e-15 76.30
IUUC-Vpa-130802 Vicugna pacos 96.63 4.00e-45 174.00
IUUC-Vvi-131105 Vitis vinifera 32.76 3.00e-33 135.00
IUUC-Xtr-132830 Xenopus tropicalis 65.94 1.00e-122 432.00
IUUC-Xma-133618 Xiphophorus maculatus 65.79 2.00e-111 395.00
IUUC-Zma-135389 Zea mays 31.53 3.00e-32 132.00
Created Date 25-Jun-2017

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