iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034198

UUCD1 version

UUC-EqC-00277

Ensembl Protein ID

ENSECAP00000020493.1

UniProt Accession

F6U8N0; F6U8N0_HORSE

Protein Name

Uncharacterized protein

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000022793.1	ENSECAT00000024659.1	ENSECAP00000020493.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-77	260.8	526	852

Active Site

Position(s)	Description	Evidence
822	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 526  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtplpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 614
           355*****************************99999999*********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG+ i V +e+++++
   Q: 615  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGAGIVVGYEDRSRF 698
           **************************************5.....56666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ +++++  +q+Fwe+l++f++e+r+
   Q: 699  IQLVQKARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDTRVQYFWEALNNFTNEDRS 785
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r+fv+++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 786  RFLRFVTGRSRLPA--------RIFVYPDklgYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 852
           *************6........8999998899999**********************************998776 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

FAMASPGVAL ESPRQLLGRV RFLAEQRETL RAVRPRPRRW LSCRAEVLYK LYKNPAPSRV 60
LLPVWEAEGL GLRVGAAGAA AGTGSGPLRA ARDSIELRRG ACVRTTGEEL CNGHGLWVKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCGCTATGG CCAGCCCGGG CGTGGCGCTA GAGTCTCCGC GGCAGCTGCT GGGCCGCGTG 60
CGCTTCCTGG CGGAGCAGCG CGAAACACTC CGCGCCGTCC GGCCGCGGCC AGTGGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	95.59	0.00e+00	1640.00
IUUC-Apl-003715	Anas platyrhynchos	84.98	0.00e+00	1311.00
IUUC-Aca-004377	Anolis carolinensis	77.69	0.00e+00	1349.00
IUUC-Ame-011918	Astyanax mexicanus	62.97	0.00e+00	1091.00
IUUC-Bta-012736	Bos taurus	96.17	0.00e+00	1656.00
IUUC-Cja-019926	Callithrix jacchus	95.47	0.00e+00	1639.00
IUUC-Cfa-020753	Canis familiaris	98.09	0.00e+00	1171.00
IUUC-Cpo-021415	Cavia porcellus	94.66	0.00e+00	1629.00
IUUC-Csa-023096	Chlorocebus sabaeus	95.59	0.00e+00	1638.00
IUUC-Dre-028746	Danio rerio	68.54	0.00e+00	1173.00
IUUC-Dno-029293	Dasypus novemcinctus	96.99	0.00e+00	1062.00
IUUC-Dor-031113	Dipodomys ordii	97.70	0.00e+00	1229.00
IUUC-Ete-032601	Echinops telfairi	89.17	0.00e+00	1421.00
IUUC-Eeu-034708	Erinaceus europaeus	97.10	0.00e+00	899.00
IUUC-Fca-035478	Felis catus	96.98	0.00e+00	1625.00
IUUC-Fal-037366	Ficedula albicollis	75.64	0.00e+00	1316.00
IUUC-Gmo-039020	Gadus morhua	74.85	0.00e+00	1039.00
IUUC-Gga-040332	Gallus gallus	78.55	0.00e+00	1370.00
IUUC-Gac-042336	Gasterosteus aculeatus	68.12	0.00e+00	1211.00
IUUC-Ggo-045382	Gorilla gorilla	95.82	0.00e+00	1644.00
IUUC-Hsa-046562	Homo sapiens	95.82	0.00e+00	1644.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	95.47	0.00e+00	1644.00
IUUC-Lch-049606	Latimeria chalumnae	64.49	0.00e+00	827.00
IUUC-Loc-052448	Lepisosteus oculatus	61.16	0.00e+00	1038.00
IUUC-Laf-054507	Loxodonta africana	94.78	0.00e+00	1644.00
IUUC-Mcc-055690	Macaca mulatta	95.70	0.00e+00	1644.00
IUUC-Meu-055970	Macropus eugenii	83.66	0.00e+00	1412.00
IUUC-Mga-059654	Meleagris gallopavo	85.19	0.00e+00	1297.00
IUUC-Mmr-061069	Microcebus murinus	95.93	0.00e+00	1647.00
IUUC-Mdo-062547	Monodelphis domestica	91.73	0.00e+00	789.00
IUUC-Mmu-063096	Mus musculus	95.24	0.00e+00	1620.00
IUUC-Mpu-065846	Mustela putorius furo	95.59	0.00e+00	1649.00
IUUC-Mlu-067992	Myotis lucifugus	96.79	0.00e+00	1563.00
IUUC-Nle-069565	Nomascus leucogenys	95.56	0.00e+00	1536.00
IUUC-Opr-070853	Ochotona princeps	83.64	0.00e+00	1008.00
IUUC-Ont-071628	Oreochromis niloticus	68.77	0.00e+00	1182.00
IUUC-Ocu-074094	Oryctolagus cuniculus	95.93	0.00e+00	1647.00
IUUC-Ola-087384	Oryzias latipes	68.89	0.00e+00	1222.00
IUUC-Oga-088224	Otolemur garnettii	96.05	0.00e+00	1653.00
IUUC-Oar-090043	Ovis aries	90.24	0.00e+00	1538.00
IUUC-Ptr-090852	Pan troglodytes	95.59	0.00e+00	1635.00
IUUC-Pan-092787	Papio anubis	95.71	0.00e+00	1645.00
IUUC-Psi-092986	Pelodiscus sinensis	72.71	0.00e+00	974.00
IUUC-Pma-094416	Petromyzon marinus	40.71	8.00e-166	577.00
IUUC-Pfo-096720	Poecilia formosa	69.09	0.00e+00	1224.00
IUUC-Pab-098325	Pongo abelii	94.64	0.00e+00	1258.00
IUUC-Pca-100885	Procavia capensis	82.87	0.00e+00	1189.00
IUUC-Pva-102829	Pteropus vampyrus	83.26	0.00e+00	1020.00
IUUC-Rno-104882	Rattus norvegicus	95.24	0.00e+00	1637.00
IUUC-Sha-106811	Sarcophilus harrisii	89.62	2.00e-113	402.00
IUUC-Sar-113020	Sorex araneus	82.42	0.00e+00	702.00
IUUC-Ssc-115436	Sus scrofa	98.15	3.00e-158	550.00
IUUC-Tgu-117042	Taeniopygia guttata	78.36	0.00e+00	1365.00
IUUC-Tru-118419	Takifugu rubripes	66.21	0.00e+00	1142.00
IUUC-Tsy-118829	Tarsius syrichta	97.32	0.00e+00	984.00
IUUC-Tni-120410	Tetraodon nigroviridis	55.62	0.00e+00	899.00
IUUC-Tbe-128113	Tupaia belangeri	97.91	0.00e+00	776.00
IUUC-Ttr-128167	Tursiops truncatus	92.10	0.00e+00	1557.00
IUUC-Xtr-132910	Xenopus tropicalis	63.23	0.00e+00	1056.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence