iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089481

Ensembl Protein ID

ENSOARP00000011492.1

UniProt Accession

W5PM18; W5PM18_SHEEP

Genbank Protein ID

ENSOARP00000011492

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01041271

Gene Name

KLHL25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000010712.1	ENSOART00000011654.1	ENSOARP00000011492.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	8.00e-20	71.2	53	121
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.00e-09	35.1	153	184

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaasS++F+a+f+++l+es+  ++v+++d + pev++ ll+F Y++++ +ne
   Q: 53   TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESH-DDTVNFQDnLHPEVLELLLDFAYSSRIVINE 121
           7************************************9.*******99*****************99886 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclg++ ++d+++c++L+++  +++l hF+
   Q: 153  PSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFE 184
           89*****************************5 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MTTGRLSMSV SVHETRKSRS STGSMNITLF HKASHPDCVL AHLNTLRKHR MFTDVTLWAG 60
DRAFPCHRAV LAASSRYFEA MFSHGLRESH DDTVNFQDNL HPEVLELLLD FAYSSRIVIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCAGTA AGTGGCTGGT GCTTGACTAT TTTTTTTTTC CTCTCTTCTG GCCTTTTCTG 60
TATGTTCATT TTCCTCCCAG GCTGTCACTC CAGGTGGCTT GCTGAAAGTG ATATCTAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002373	Ailuropoda melanoleuca	95.25	0.00e+00	1191.00
IUUC-Apl-003543	Anas platyrhynchos	88.47	0.00e+00	1081.00
IUUC-Aca-004729	Anolis carolinensis	85.40	0.00e+00	1061.00
IUUC-Ame-011020	Astyanax mexicanus	84.21	0.00e+00	1030.00
IUUC-Bta-012955	Bos taurus	99.32	0.00e+00	1224.00
IUUC-Cja-018839	Callithrix jacchus	94.57	0.00e+00	1181.00
IUUC-Cfa-020224	Canis familiaris	95.93	0.00e+00	1199.00
IUUC-Cpo-021593	Cavia porcellus	92.36	0.00e+00	1112.00
IUUC-Csa-023276	Chlorocebus sabaeus	95.25	0.00e+00	1188.00
IUUC-Dre-028053	Danio rerio	84.38	0.00e+00	1002.00
IUUC-Dno-029287	Dasypus novemcinctus	94.74	0.00e+00	1177.00
IUUC-Dor-030908	Dipodomys ordii	86.93	0.00e+00	1066.00
IUUC-Fca-035897	Felis catus	96.10	0.00e+00	1195.00
IUUC-Fal-037036	Ficedula albicollis	88.46	0.00e+00	1086.00
IUUC-Gmo-039345	Gadus morhua	84.38	0.00e+00	1002.00
IUUC-Gga-040404	Gallus gallus	88.29	0.00e+00	1087.00
IUUC-Gac-042447	Gasterosteus aculeatus	83.87	0.00e+00	1016.00
IUUC-Ggo-045060	Gorilla gorilla	95.08	0.00e+00	1187.00
IUUC-Hsa-046494	Homo sapiens	95.08	0.00e+00	1186.00
IUUC-Itr-047993	Ictidomys tridecemlineatus	95.59	0.00e+00	1194.00
IUUC-Lch-050211	Latimeria chalumnae	85.03	0.00e+00	1041.00
IUUC-Loc-052578	Lepisosteus oculatus	84.07	0.00e+00	1036.00
IUUC-Lma-053168	Leptosphaeria maculans	29.79	7.00e-05	41.60
IUUC-Laf-053498	Loxodonta africana	94.57	0.00e+00	1133.00
IUUC-Mcc-055033	Macaca mulatta	95.08	0.00e+00	1187.00
IUUC-Meu-056893	Macropus eugenii	90.49	0.00e+00	1135.00
IUUC-Mga-060025	Meleagris gallopavo	88.46	0.00e+00	1087.00
IUUC-Mmr-060658	Microcebus murinus	95.59	0.00e+00	1189.00
IUUC-Mdo-062667	Monodelphis domestica	90.49	0.00e+00	1137.00
IUUC-Mmu-063125	Mus musculus	92.53	0.00e+00	1125.00
IUUC-Mpu-066209	Mustela putorius furo	95.59	0.00e+00	1194.00
IUUC-Mlu-068237	Myotis lucifugus	93.04	0.00e+00	1132.00
IUUC-Nle-069454	Nomascus leucogenys	95.03	0.00e+00	1173.00
IUUC-Ont-072138	Oreochromis niloticus	84.21	0.00e+00	1003.00
IUUC-Oan-073320	Ornithorhynchus anatinus	86.42	0.00e+00	1080.00
IUUC-Ocu-073765	Oryctolagus cuniculus	91.17	0.00e+00	1105.00
IUUC-Ola-086620	Oryzias latipes	71.65	0.00e+00	883.00
IUUC-Oga-088002	Otolemur garnettii	95.59	0.00e+00	1187.00
IUUC-Ptr-091200	Pan troglodytes	94.91	0.00e+00	1182.00
IUUC-Psi-093884	Pelodiscus sinensis	87.61	0.00e+00	1075.00
IUUC-Pma-094515	Petromyzon marinus	60.21	0.00e+00	664.00
IUUC-Pno-095143	Phaeosphaeria nodorum	26.83	1.00e-14	73.60
IUUC-Pva-102321	Pteropus vampyrus	94.23	0.00e+00	1181.00
IUUC-Rno-104835	Rattus norvegicus	92.02	0.00e+00	1122.00
IUUC-Sha-107528	Sarcophilus harrisii	90.32	0.00e+00	1134.00
IUUC-Ssc-116161	Sus scrofa	96.60	0.00e+00	1199.00
IUUC-Tgu-116569	Taeniopygia guttata	88.29	0.00e+00	1083.00
IUUC-Tni-120525	Tetraodon nigroviridis	75.80	0.00e+00	881.00
IUUC-Ttr-129297	Tursiops truncatus	97.28	0.00e+00	1210.00
IUUC-Xtr-132302	Xenopus tropicalis	83.53	0.00e+00	1057.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence