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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046738
UUCD1 version UUC-HoS-00744
Ensembl Protein ID ENSP00000337500.5
UniProt Accession Q86SE9; B7Z892; D3DR33; Q6PK47; Q86TD0; PCGF5_HUMAN
Genbank Protein ID BAH13878.1; CAD89905.1; CAD91165.1; EAW50112.1; EAW50113.1; AAH07377.1; AAH51845.1
Protein Name Polycomb group RING finger protein 5; RING finger protein 159
Genbank Nucleotide ID AK303014; AL832003; AL832496; CH471066; CH471066; BC007377; BC051845
Gene Name PCGF5; RNF159
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000180628.14 ENST00000336126.5 ENSP00000337500.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/RAWUL RAWUL 18588675; 21282530; 22325352
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0035 19.5 18 56
ULD/UDP/UFD/RAWUL 7.00e-32 111.4 139 250
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C iC+  + +++ v+ C H+f+++C+ q++      +  ++ CP C
   Q: 18   CYICKGYLIKPTTVTECLHTFCKTCIvQHF------EDSND-CPRC 56
           99********999*************7777......55555.9988 PP
   

   ULD/UDP/UFD/RAWUL
   S: 1    islsLeplesnkakddsk...lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk............. 76
           i+++L++l++n++++d++   l+kk++rcs+r+tV+++kkfl++klkl+ssye+d+lc++e++++++t+e+i y+++w+             
   Q: 139  IAICLDCLRNNGQSGDNVvkgLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFI-YMTRWRlrgenfrclncsa 229
           79**********************************************************************.******************* PP
   S: 77   ...........kegpLvLqYr 86
                      +++p+vLqYr
   Q: 230  sqvcsqdgplyQSYPMVLQYR 250
           ********************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.
 Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.
Protein Sequence
(Fasta)
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV 60
HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK NKPQENGQDD TSKADKPKVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046738|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCACGCGCG CGCGCTCGCG CACCACGCGC CCCGCGCGGC CCGCCCGGAT CGTGGCCTCT 60
CGAGAGCAAG GTAAGGGCGA TGCGCGGGGA CCCAGGCGGC TTCCCCGCCC GACGCGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046738|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0005813--C:centrosome
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008270--F:zinc ion binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG hsa:84333
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002093 Ailuropoda melanoleuca 98.07 6.00e-134 469.00
IUUC-Apl-003757 Anas platyrhynchos 95.31 1.00e-122 432.00
IUUC-Aca-005032 Anolis carolinensis 88.28 3.00e-112 397.00
IUUC-Ame-011418 Astyanax mexicanus 69.11 1.00e-93 335.00
IUUC-Bta-013081 Bos taurus 98.44 6.00e-133 466.00
IUUC-Cja-019296 Callithrix jacchus 95.31 3.00e-133 467.00
IUUC-Cfa-020437 Canis familiaris 98.44 5.00e-134 469.00
IUUC-Cpo-022107 Cavia porcellus 98.06 9.00e-134 469.00
IUUC-Csa-023103 Chlorocebus sabaeus 100.00 6.00e-136 476.00
IUUC-Cho-025053 Choloepus hoffmanni 54.69 1.00e-58 219.00
IUUC-Dre-028409 Danio rerio 71.88 2.00e-97 348.00
IUUC-Dno-030077 Dasypus novemcinctus 98.44 3.00e-134 470.00
IUUC-Dor-030893 Dipodomys ordii 98.62 3.00e-111 394.00
IUUC-Ete-033131 Echinops telfairi 80.47 2.00e-107 381.00
IUUC-Eca-034226 Equus caballus 95.70 8.00e-130 456.00
IUUC-Eeu-034466 Erinaceus europaeus 80.47 2.00e-104 371.00
IUUC-Fca-035545 Felis catus 99.22 2.00e-135 474.00
IUUC-Fal-037615 Ficedula albicollis 95.31 1.00e-122 432.00
IUUC-Gmo-038871 Gadus morhua 68.24 3.00e-80 291.00
IUUC-Gga-040926 Gallus gallus 93.75 6.00e-128 449.00
IUUC-Gac-042006 Gasterosteus aculeatus 76.08 2.00e-99 355.00
IUUC-Ggo-045087 Gorilla gorilla 100.00 6.00e-136 476.00
IUUC-Itr-048443 Ictidomys tridecemlineatus 98.41 6.00e-93 332.00
IUUC-Lch-050434 Latimeria chalumnae 82.42 4.00e-114 404.00
IUUC-Loc-052649 Lepisosteus oculatus 78.21 1.00e-105 375.00
IUUC-Laf-053509 Loxodonta africana 98.83 1.00e-134 472.00
IUUC-Mcc-055709 Macaca mulatta 99.61 2.00e-135 474.00
IUUC-Meu-056663 Macropus eugenii 78.12 5.00e-103 367.00
IUUC-Mga-059573 Meleagris gallopavo 93.70 2.00e-126 444.00
IUUC-Mmr-060776 Microcebus murinus 98.44 4.00e-133 467.00
IUUC-Mdo-061959 Monodelphis domestica 97.66 5.00e-133 466.00
IUUC-Mmu-063483 Mus musculus 89.45 3.00e-110 390.00
IUUC-Mpu-066861 Mustela putorius furo 99.22 2.00e-135 474.00
IUUC-Mlu-067880 Myotis lucifugus 98.83 1.00e-134 472.00
IUUC-Nle-069264 Nomascus leucogenys 100.00 6.00e-136 476.00
IUUC-Opr-070746 Ochotona princeps 70.70 3.00e-82 297.00
IUUC-Ont-071361 Oreochromis niloticus 75.19 3.00e-99 354.00
IUUC-Oan-073482 Ornithorhynchus anatinus 80.23 2.00e-105 374.00
IUUC-Ocu-073885 Oryctolagus cuniculus 98.44 3.00e-134 470.00
IUUC-Ola-086999 Oryzias latipes 76.47 9.00e-105 372.00
IUUC-Oga-088504 Otolemur garnettii 98.44 2.00e-134 471.00
IUUC-Oar-089963 Ovis aries 98.44 2.00e-134 471.00
IUUC-Ptr-090820 Pan troglodytes 99.22 3.00e-135 473.00
IUUC-Pan-092600 Papio anubis 99.61 2.00e-135 474.00
IUUC-Psi-093699 Pelodiscus sinensis 94.53 7.00e-122 429.00
IUUC-Pma-094238 Petromyzon marinus 64.59 2.00e-87 315.00
IUUC-Pfo-096402 Poecilia formosa 71.71 1.00e-94 338.00
IUUC-Pab-097621 Pongo abelii 100.00 6.00e-136 476.00
IUUC-Pca-100342 Procavia capensis 97.66 4.00e-134 470.00
IUUC-Pva-103118 Pteropus vampyrus 98.83 3.00e-128 451.00
IUUC-Rno-105427 Rattus norvegicus 95.56 8.00e-105 372.00
IUUC-Sha-107627 Sarcophilus harrisii 92.06 3.00e-90 323.00
IUUC-Sar-113005 Sorex araneus 86.33 3.00e-121 427.00
IUUC-Ssc-116448 Sus scrofa 82.76 7.00e-76 276.00
IUUC-Tgu-117081 Taeniopygia guttata 95.31 1.00e-122 432.00
IUUC-Tru-117696 Takifugu rubripes 70.68 3.00e-95 341.00
IUUC-Tsy-119052 Tarsius syrichta 83.49 5.00e-97 346.00
IUUC-Tni-120530 Tetraodon nigroviridis 72.69 4.00e-92 330.00
IUUC-Tbe-127914 Tupaia belangeri 79.69 2.00e-106 378.00
IUUC-Ttr-128739 Tursiops truncatus 83.98 7.00e-106 376.00
IUUC-Vpa-130189 Vicugna pacos 97.66 1.00e-131 461.00
IUUC-Xtr-131995 Xenopus tropicalis 77.82 1.00e-101 362.00
IUUC-Xma-133038 Xiphophorus maculatus 76.68 2.00e-88 318.00
Created Date 25-Jun-2017

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