iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000005631.2	ENSCJAT00000011192.2	ENSCJAP00000010594.2
ENSCJAG00000005631.2	ENSCJAT00000011208.1	ENSCJAP00000010609.1
ENSCJAG00000005631.2	ENSCJAT00000011211.2	ENSCJAP00000010612.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-124	414.8	2157	2615

Active Site

Position(s)	Description	Evidence
2584	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg++l+++n  d+e+++++   glk+p                     
   Q: 2157 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGAWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2242
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2243 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2329
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2330 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilsnkglsedekntklqelvlknpsgsgpplSIEDLGLN 2416
           7777777777766666668***********************9334455555666777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr+Gfn+v+p+e+ls+F++ee+++++cG+   +
   Q: 2417 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGN---Q 2499
           *************999.******************************************************************...6 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nTC++
   Q: 2500 SPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNTCVH 2586
           666666665555555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2587 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2615
           ***********************.****86 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTCTCGG GAACTCGAGG GCCGCGGCCG GGCCTGGCTC TGTCCGCGGC CTGGTGGGAG 60
CTGGACTGGA GCGGTTTGGG ACTACAAGCC CGAGTAAGAG CCTGCGGGAA GGGGAGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	98.28	0.00e+00	4613.00
IUUC-Apl-003493	Anas platyrhynchos	94.52	0.00e+00	4458.00
IUUC-Aca-004521	Anolis carolinensis	94.94	0.00e+00	2753.00
IUUC-Ame-011258	Astyanax mexicanus	89.62	0.00e+00	2334.00
IUUC-Bta-012835	Bos taurus	98.36	0.00e+00	4628.00
IUUC-Cel-018153	Caenorhabditis elegans	52.31	5.00e-169	589.00
IUUC-Cfa-021115	Canis familiaris	98.20	0.00e+00	4569.00
IUUC-Cpo-022382	Cavia porcellus	94.66	0.00e+00	4393.00
IUUC-Csa-023230	Chlorocebus sabaeus	98.70	0.00e+00	4630.00
IUUC-Cho-024711	Choloepus hoffmanni	96.50	0.00e+00	1653.00
IUUC-Cin-025342	Ciona intestinalis	52.92	0.00e+00	1365.00
IUUC-Csv-026031	Ciona savignyi	51.54	0.00e+00	1395.00
IUUC-Dre-027435	Danio rerio	86.18	0.00e+00	4061.00
IUUC-Dno-029954	Dasypus novemcinctus	98.17	0.00e+00	4581.00
IUUC-Dor-030734	Dipodomys ordii	97.50	0.00e+00	1471.00
IUUC-Dme-031739	Drosophila melanogaster	59.52	0.00e+00	1616.00
IUUC-Ete-033192	Echinops telfairi	90.83	0.00e+00	1182.00
IUUC-Eca-033434	Equus caballus	98.62	0.00e+00	4626.00
IUUC-Eeu-035031	Erinaceus europaeus	83.09	0.00e+00	1074.00
IUUC-Fca-035998	Felis catus	96.79	0.00e+00	4509.00
IUUC-Fal-037468	Ficedula albicollis	93.92	0.00e+00	2755.00
IUUC-Gmo-038495	Gadus morhua	90.58	0.00e+00	1365.00
IUUC-Gga-040736	Gallus gallus	95.77	0.00e+00	2765.00
IUUC-Gac-041777	Gasterosteus aculeatus	90.38	0.00e+00	2372.00
IUUC-Ggo-044677	Gorilla gorilla	95.27	0.00e+00	4405.00
IUUC-Hsa-045879	Homo sapiens	98.70	0.00e+00	4630.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	98.43	0.00e+00	4623.00
IUUC-Lch-050444	Latimeria chalumnae	91.11	0.00e+00	4142.00
IUUC-Loc-051986	Lepisosteus oculatus	87.40	0.00e+00	4111.00
IUUC-Laf-054230	Loxodonta africana	98.02	0.00e+00	4548.00
IUUC-Mcc-054787	Macaca mulatta	98.70	0.00e+00	4630.00
IUUC-Meu-056502	Macropus eugenii	89.16	0.00e+00	1332.00
IUUC-Mga-059409	Meleagris gallopavo	91.14	0.00e+00	2078.00
IUUC-Mmr-061667	Microcebus murinus	98.70	0.00e+00	4610.00
IUUC-Mdo-061960	Monodelphis domestica	96.64	0.00e+00	4551.00
IUUC-Mmu-063941	Mus musculus	97.44	0.00e+00	4576.00
IUUC-Mpu-065939	Mustela putorius furo	98.36	0.00e+00	4618.00
IUUC-Mlu-068112	Myotis lucifugus	97.97	0.00e+00	4574.00
IUUC-Nle-069001	Nomascus leucogenys	98.62	0.00e+00	4628.00
IUUC-Opr-071222	Ochotona princeps	93.07	0.00e+00	2072.00
IUUC-Ont-072101	Oreochromis niloticus	85.19	0.00e+00	2573.00
IUUC-Oan-072814	Ornithorhynchus anatinus	96.48	0.00e+00	4518.00
IUUC-Ocu-074011	Oryctolagus cuniculus	98.43	0.00e+00	4619.00
IUUC-Ola-086412	Oryzias latipes	89.96	0.00e+00	2353.00
IUUC-Oar-089668	Ovis aries	98.43	0.00e+00	4622.00
IUUC-Ptr-090517	Pan troglodytes	98.85	0.00e+00	4615.00
IUUC-Pan-091849	Papio anubis	96.02	0.00e+00	4455.00
IUUC-Psi-093390	Pelodiscus sinensis	92.61	0.00e+00	2666.00
IUUC-Pma-094628	Petromyzon marinus	81.70	0.00e+00	1540.00
IUUC-Pfo-097075	Poecilia formosa	90.70	0.00e+00	2396.00
IUUC-Pab-098176	Pongo abelii	98.70	0.00e+00	4630.00
IUUC-Pca-101123	Procavia capensis	93.97	0.00e+00	2486.00
IUUC-Pva-103008	Pteropus vampyrus	94.37	0.00e+00	1892.00
IUUC-Rno-105885	Rattus norvegicus	97.74	0.00e+00	4586.00
IUUC-Sha-107048	Sarcophilus harrisii	95.20	0.00e+00	4472.00
IUUC-Sar-113071	Sorex araneus	93.97	0.00e+00	1275.00
IUUC-Ssc-115963	Sus scrofa	98.05	0.00e+00	4603.00
IUUC-Tgu-117167	Taeniopygia guttata	93.73	0.00e+00	2622.00
IUUC-Tru-118626	Takifugu rubripes	91.53	0.00e+00	2447.00
IUUC-Tsy-119504	Tarsius syrichta	95.44	0.00e+00	2276.00
IUUC-Tni-119877	Tetraodon nigroviridis	90.56	0.00e+00	2380.00
IUUC-Tbe-127602	Tupaia belangeri	97.41	0.00e+00	995.00
IUUC-Ttr-128394	Tursiops truncatus	97.98	0.00e+00	3124.00
IUUC-Vpa-130280	Vicugna pacos	97.98	0.00e+00	4417.00
IUUC-Xtr-131787	Xenopus tropicalis	85.12	0.00e+00	2537.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence